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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: spermatogenesis,Infertility,Cyclophosphamide,Garlic,Orchid
- چکیده:
- چکیده انگلیسی: Background:One of the most common side effects of cyclophosphamide (CP) is oligo-spermatozoa, azoospermia and elimination of spermatogenic cycles. This study was done to find the efficacy of simultaneous consumption of garlic (Allium sativum L.) and orchid (Orchismaculata L.) hydroalcoholic extracts on spermatogenesis and sex hormones in rats treated with CP. Methods:Forty-two male rats were divided into the six groups: control, sham, CP
(5 mg/kg), garlic (10 mg/kg) + CP, orchid (40 mg/kg) + CP, garlic+ orchid + CP. All of the agents were administered through oral gavage for 28 days. Results: The number of sperms increased in garlic+ CP and orchid+ CP groups. The percentage of sperm forward motility increased in groups receiving garlic, orchid, and garlic +orchid compared with the group that received only CP. Antioxidant total capacity and testosterone level showed significant increases in garlic+ orchid, garlic and orchid groups respectively compared with the group that received only CP (P<0.05). Also, the tissue and serum malondialdehyde levels reduced in the group received garlic +orchid compared with the group that received only CP. Conclusion:Garlic and orchid could increase the number and the motility of sperms, index of sertoli cell, antioxidant capacity and serum testosterone level.- انتشار مقاله: 07-04-1398
- نویسندگان: Firouze Sadeghzadeh,Azizieh Sadeghzadeh,Saeed Changizi-Ashtiyani,Abass Alimoradian,Mehry Mashayekhei,Ali Zarei,Farideh Jalali-Mashayekhi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Liver,lipid profile,Hypercholesterolemia,Rosa Canina L
- چکیده:
- چکیده انگلیسی: Background: Rosa Canina L. is a medicinal plant with many therapeutic applications in traditional medicine. This study aimed to evaluate the effectiveness of the extract of Rosa Canina on liver function, lipid profiles and thyroid hormones in hypercholesterolemic rats. Methods: In this experimental study, 60 male Wistar rats were divided into 6 groups (n=10): the control group, hypercholesterolemic vehicle with a diet containing 2% cholesterol, hypercholesterolemia groups receiving either the extract of Rosa Canina L. at doses of 50, 500, 1000, or Atorvastatin at a dose of 10 mg/kg as gavage for 48 days. Results: The extract of Rosa Canina L lowered cholesterol and triglycerides from 96±1.3 and
111.8±4.8 in the vehicle group to 79.5±2.4, 98.7±3.5, 73.3±2.5 and 77.5±3.2 in the groups treated with the extract at doses of 500 mg/kg and 1000 mg/kg, respectively. The levels of liver enzymes including alanine transaminase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were lowered significantly in the group treated with the extract at the dose of 500mg/kg and in the groups treated with the extract at the dose of 1000 mg/kg (P<0.05). The serum levels of thyroid-stimulating hormone and thyroxin in the group treated with the extract at the dose of 1000 and thyroxin at the dose of 500 mg/kg was reduced and the level of triiodothyronine increased compared with the hypercholesterolemic group (P<0.05). Conclusion: Rosa Canina L has healing effects on dyslipidemia and liver protection along with changes in thyroid hormones secretion pattern.- انتشار مقاله: 11-09-1396
- نویسندگان: Saeed Changizi-Ashtiyani,Somayeh Berenji,Ali Zarei,Majid Ramezani,Nasser Hosseini
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: cancer,Liver,diabetes,Hyperlipidemia,Thyroid,Chelidonium majus
- چکیده:
- چکیده انگلیسی: Background: Using herbs for the treatment of diseases has a long history. Chelidonium majus from the family of Papaveraceae is one of the best-known and most widely used herbs used in traditional medicine. The aim of this study was to review its active components, as well as its therapeutic and toxic effects on body tissues.
Methods: This short overview was done by searching for relevant contents in many databases including: Magiran, Iran medex, IranDoc, SID, Medlib, Web of Science, Scopus, PubMed, Science Direct and Google Scholar. All articles that met the inclusion criteria were studied and evaluated.
Results: The various compounds available in the plant such as: alkaloids, flavonoids, and opioid derivatives, as well as its ability to produce nitric oxide(NO) and tumor necrosis factor(TNF) and its multiple capabilities in affecting the activities of various body tissues in hepatic, renal, neurological, reproductive and hormonal systems have made it a leading plant in the listofmedicinalherbs.The levels of the active compounds in the plants are influenced by location, altitude, ambient temperature and harvest time, a fact which partly justifies the controversial reports on the effects of this extract on body tissues.
Conclusion: Because of the multiplicity and diversity of its active ingredients, Chelidonium majus has the potential to be used for the diagnosis, treatment and control of hard to treat diseases (HTDS). However, it is recommended to do more research on its mechanism and its possible adverse effects.- انتشار مقاله: 12-12-1395
- نویسندگان: Saeed Changizi-Ashtiyani,Ali Zarei,Azam Rezaei,Majid Ramezani,Alireza Tavakol
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Avicenna,Rhazes,Pterygium,Islamic Civilization,Haly Abbas,Jurjani,Jesu Haly
- چکیده:
- چکیده انگلیسی: Background: Pterygium is one of the eye diseases that have been a subject of interest since ancient times. The aim of this study was to trace back the methods of diagnosis and treatment of pterygium throughout the history of Islamic civilization and to learn about the drugs and the related surgical instruments used to treat it. Methods: We searched all available reliable electronic and published sources for the views of ancient Iranian physicians including Avicenna, Rhazes, Jurjani, and compared them with what has been mentioned about this disease in recent medical literature. Results: As Islamic countries were among the regions with pterygium outbreak, it received much attention by Islamic scholars and many discoveries and innovations were made by Iranian-Islamic sages. Especially in the treatment of the disease, they outdid their Greek counterparts. Among these scholars, Rhazes in Al-Hawi, Haly Abbas in Kamel al Sanaye, Avicenna in Al-Qanun fi Tibb, Jurjani in Kharazmshahi Treasure and Jesu Haly in Tazkarat al Kahhalin have suggested highly detailed and practical prescriptions for the disease showing their ingenuity and their careful clinical examination many of which are still valid in modern medicine for the treatment of the disease. Conclusion: Unlike today's treatment of a disease which is based on a single protocol, in Islamic - Iranian traditional medicine a disease might be treated differently according to the temperament and characteristics of each individual patient. In addition, the doctors would not isolate the affected part from other parts of the body or mind and they always would first thoroughly cleanse the body and then they would start the treatment.
- انتشار مقاله: 18-10-1395
- نویسندگان: Zahra Mansouri,Mohammad Reza Rajabnejad,Reza Rezaei,Bahman Tavan,Ali Zarei,Saeed Changizi-Ashtiyani
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Advances in Environmental Health Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Adsorption,activated carbon,Perchlorate,Reductive degradation,Ni/Fe bimetallic nanoparticles
- چکیده:
- چکیده انگلیسی: In the present study, nickel and iron (Ni/Fe) bimetallic nanoparticles (Ni-Fe NPs) were produced in the presence of activated carbon (AC) to prepare supported Ni/Fe bimetallic nanoparticles (Ni-Fe NPs/AC). The NPs were modified using cetylpyridinium chloride and used for the simultaneous adsorption and degradation of perchlorate. Synthesized Ni-Fe NPs/AC was characterized using FE-SEM, EDS, and XRD. The influential factors in the removal of perchlorate by Ni-Fe NPs/AC were optimized based on experimental design. According to the results, adsorption and degradation efficiencies were 96.98% and 78.81%, respectively, which could be achieved to the efficiency of nearly 100% by increasing the process time to 110 minutes. Reaction kinetics complied with the pseudo-first-order characteristics. Moreover, the rate constant of adsorption and degradation were estimated at 0.0848 and 0.0199 min-1 at 303 K, and the activation energy for adsorption and degradation was 42.39 and 12.47 kJ/mol, respectively. The proposed method could effectively remove perchlorate from well water and industrial wastewater. Therefore, Ni-Fe NPs/AC could be an effective nanomaterial for the complete degradation of perchlorate. This novel method could also remove persistent organic and inorganic pollutants and promote the industrial application of bimetallic NPs in environmental remediation.
- انتشار مقاله: 14-02-1398
- نویسندگان: Ali Reza Zarei,Ali Moloudi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Advances in Environmental Health Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Adsorption,activated carbon,Perchlorate,Reductive degradation,Ni/Fe bimetallic nanoparticles
- چکیده:
- چکیده انگلیسی: In the present study, nickel and iron (Ni/Fe) bimetallic nanoparticles (Ni-Fe NPs) were produced in the presence of activated carbon (AC) to prepare supported Ni/Fe bimetallic nanoparticles (Ni-Fe NPs/AC). The NPs were modified using cetylpyridinium chloride and used for the simultaneous adsorption and degradation of perchlorate. Synthesized Ni-Fe NPs/AC was characterized using FE-SEM, EDS, and XRD. The influential factors in the removal of perchlorate by Ni-Fe NPs/AC were optimized based on experimental design. According to the results, adsorption and degradation efficiencies were 96.98% and 78.81%, respectively, which could be achieved to the efficiency of nearly 100% by increasing the process time to 110 minutes. Reaction kinetics complied with the pseudo-first-order characteristics. Moreover, the rate constant of adsorption and degradation were estimated at 0.0848 and 0.0199 min-1 at 303 K, and the activation energy for adsorption and degradation was 42.39 and 12.47 kJ/mol, respectively. The proposed method could effectively remove perchlorate from well water and industrial wastewater. Therefore, Ni-Fe NPs/AC could be an effective nanomaterial for the complete degradation of perchlorate. This novel method could also remove persistent organic and inorganic pollutants and promote the industrial application of bimetallic NPs in environmental remediation.
- انتشار مقاله: 14-02-1398
- نویسندگان: Ali Reza Zarei,Ali Moloudi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Otorhinolaryngology
- نوع مقاله: Journal Article
- کلمات کلیدی: Sore throat,Lidocaine,Beclomethasone
- چکیده:
- چکیده انگلیسی: Introduction:
Post-operative sore throat and cough are common complications of endotracheal intubation. These conditions may be very distressing for the patient and may lead to unpleasant memories. This study was performed in order to determine whether beclomethasone and lidocaine spray could reduce the frequency of post-operative sore throat and hoarseness after tracheal extubation.
Materials and Methods:
Ninety women (18–60 years of age) with an American Society of Anesthesiologists (ASA) physical status I or II and undergoing elective mastoidectomy were randomized into three groups of 30 patients. The endotracheal tubes in each group were sprayed with 50% beclomethasone, 10% lidocaine hydrochloride, or normal saline (control group) before endotracheal intubation. Patients were examined for sore throat (none, mild, moderate, or severe), cough, and hoarseness at 1 and 24 h after extubation.
Results:
There was a significantly lower incidence and severity of post-operative sore throat in the beclomethasone group than the lidocaine and control groups (P<0.05) at each observation time point. At 24 h after extubation, the incidence and severity of sore throat and cough was significantly lower in the lidocaine compared with the control group. The incidence of hoarseness was not significantly different among the three groups.
Conclusion:
Spraying beclomethasone and lidocaine on the endotracheal tube is a simple and effective method to reduce the incidence and severity of post-operative sore throat.- انتشار مقاله: 29-02-1393
- نویسندگان: Nadia Banihashem,Ebrahim Alijanpour,Bahman Hasannasab,Ali Zarei
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of English for Academic Purposes
- نوع مقاله: Journal Article
- کلمات کلیدی: academic writing,Research Article Abstracts,Noun Phrases,Phrasal Complexity
- چکیده: یکی از ویژگیهای بارز نوشتار آکادمیک، بر خلاف زبان گفتار، استفاده مکرر از گروه اسمی است که این خود فرایند درک متن را برای خوانندگان با مهارت کمتر دشوار میکند. مطالعه فعلی با استفاده از بخشی از مدل پیشنهادی مراحل رشد نوشتاری بایبر و همکاران (2011( و با تمرکز بر توصیف کننده های گروه اسمی، به مقایسه بخش چکیده مقالات نوشته شده توسط نویسندگان ایرانی و غیر ایرانی میپردازد. پس از برچسب گذاری متن و شناسایی تعریف کننده های گروه اسمی بوسیله نرم افزار متن کاوی، فراوانی نسبی 15 نوع از تعریف کننده های گروه اسمی در بین دو گروه مورد مقایسه قرار گرفت. یافته های این مطالعه نشان داد که تعداد مجموع تعریف کننده های اسمی، بند موصولی، و تعریف کننده های حروف اضافه در بین نویسندگان غیر ایرانی بطور معنا داری بیشتر از تعداد استفاده آنها در بین نویسندگان ایرانی است. بررسی میزان فورمولیک بودن تعریف کننده های شناسایی شده مشخص نمود که نویسندگان ایرانی بیش از نویسندگان غیر ایرانی از خوشه های واژگانی برای ساخت تعریف کننده های گروه اسمی استفاده میکردند. یافته های این مطالعه به همراه کاربردهای آموزشی آن به بحث گذاشته میشود.
- چکیده انگلیسی: Unlike conversation, academic writing is characterized by the frequent use of noun phrases which make it difficult for less proficient readers to process a text. Using a subset of Biber, Gray, and Poonpon’s (2011) hypothesized developmental stages of writing, we analyzed noun phrase modifiers in applied linguistics research article (RA) abstracts between expert non-native English Persian writers and international writers. To that end, a 38,762-word corpus was constructed, consisting of 109 international academic research articles (RAs) and 100 Persian English-medium RAs randomly chosen from international peer-reviewed journals and Persian English-medium peer-reviewed journals. Using an automatic extraction computer program (PyCharm, version 3.4.), we tagged texts, identified noun phrase modifiers, and compared the normalized frequency of the modifiers between two writer groups. Independent-samples t-tests and chi-square tests of independence were run to analyze the data. The findings revealed that international writers differed significantly from Persian writers in the use of total noun phrase modifiers, relative clauses, and post-modifying prepositional phrases. Results from the analysis of lexical bundles indicated that Persian writers used lexical bundles to modify noun phrases more frequently than international writers. The findings of this study offer insights into the way expert international and non-native academic writers in applied linguistics make use of phrasal features for complexifying RA abstracts.
- انتشار مقاله: 01-12-1398
- نویسندگان: Mohammad Ahmadi,Rajab Esfandiari,Abbas Ali Zarei
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: diabetes,Glucose,Streptozotocin,Salvia hydrangea
- چکیده:
- چکیده انگلیسی: Objective(s): This study was to investigate the potential anti-diabetic effects of alcoholic extract of Salvia hydrangea in rats. Materials and Methods:Thirty five male Wistar rats were divided into five groups namely non-diabetic control, diabetic control, and three experimental diabetic that received either Salvia hydrangea extract for 21 days at the doses of 100 and 200 or glibenclamide at the dose of 10 mg/kg through gavage feeding. To induce diabetes, streptozotocin was injected intraperitoneally. Results:Insulin and HDL levels in the group receiving the high dose of the extract showed significant increase, whereas the amount of cholesterol in rats that received glibenclamide and the extract showed a significant decrease as compared to the diabetic control group (P<0.05). The blood glucose levels showed significant reduction in all experimental groups (P<0.05). Conclusion: Consumption of the extract of the aerial parts of S. hydrangea which reduces blood fat and increases insulin may have beneficial effects on the symptoms of diabetes and hyperlipidemia.
- انتشار مقاله: 13-02-1394
- نویسندگان: Ali Zarei,Gholamhasan Vaezi,Ali Akbar Malekirad,Mohammad Abdollahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Biotechnology
- نوع مقاله: Journal Article
- کلمات کلیدی: Prostate cancer,Polymorphism,PCR-RFLP,PCR-SSCP,ABCC1,Codon 72 p53
- چکیده:
- چکیده انگلیسی: Background: In prostate cancer, mutated p53 alleles typically contain missense single-base substitution in codon 72 that resides within exons 5-8. Stable p53 proteins in tumor cell nuclei have been associated with malignancy. A role of p53 is the regulation of drug transporters like ABCC1 (MRP1) by an effect on promoter region. Objectives: The objective of this study was to identify association of mutations of p53 at codon 72 and 282 and promoter region of ABCC1 with increased risks of prostate cancer. Materials and Methods: Formalin fixed, paraffin-embedded malignant tissues of 45 patients and 45 control samples were evaluated. PCR-RFLP using BstUI for codon 72 and HpaII restriction enzyme for codon 282 p53 gene, and G-1666A promoter region of ABCC1 gene was performed. To assess the frequency of these mutations and to detect new mutations in cancerous samples, PCR-SSCP analysis was performed. Results: The frequencies of CC, GC and GG genotypes of codon 72 of p53 were 33.33%, 46.67% and 20.00% in patients with cancer and 15.56%, 48.89% and 35.55% in controls, respectively. The relative allele frequencies of ABCC1 promoter polymorphism were 60.00% A and 40.00% G in patients as opposed to 37.78% for A and 62.22% for G in controls. Genotypic frequencies of p53 codon 72 and G1666A of ABCC1 in patients vs. Controls were statistically significant(p<0.05). The study of these samples with PCR-SSCP displayed some new banding patterns. Conclusions: The present findings suggest that CC homozygosity in codon 72 of p53 gene and AA genotype in G-1666A of ABCC1 gene may play a role in combination in prostate cancer and increased susceptibility for this malignancy in the Iranian Kurdish population.
- انتشار مقاله: 15-09-1393
- نویسندگان: Farinaz Behfarjam,Jalal Rostamzadeh,Mohammad Ali Zarei,Bahram Nikkhoo
- مشاهده