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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Advanced Herbal Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Gastric ulcers,Medicinal plant,HPLC,Second metabolism
- چکیده:
- چکیده انگلیسی: Background and aims: Medicinal plants are a valuable resource for flavonoids extraction. Prosopis fracta is one of the plants with medicinal properties. Prosopis fracta was found in abundance in southern regions in Iran. Coersetin is medicinal substance found in the fruit of this plant. Quercetin is used in treatment of cancer and viral infections. This study was conducted to determine the Quercetin flavonoid in Prosopis fracta samples in different regions of Khuzestan. Methods: The Prosopis fracta fruit collected from different regions of Khuzestan (Susangerd, Ahvaz, Abadan, Mollasani, Behbahan and Ramhormoz). The beads were isolated from the fruit. Shell and the flesh were dried in an Oven. The dried materials were mixed and flavonoids extracted with a suitable solvent. The extract was injected into the High Performance Liquid Chromatography (HPLC) system. Then, the compound, Quercetin quantity and standard peak in each sample have been determined. Results: Based on the results, the Susangerd samples (0.0033 mg/ml) and Abadan (0.0008 mg/ml) have maximum and minimum levels of Quercetin flavonoid, respectively. Conclusions: Quercetin flavonoid extracted from Prosopis farcta fruits of Susangerd is richer than other regions of Khuzestan province. Therefore, it is recommended to use the Prosopis fracta fruit grown in Susangerd for extraction of the Quercetin flavonoid.
- انتشار مقاله: 26-04-1393
- نویسندگان: Fatemeh Direkvand-Moghadam,Vahid Ghasemi-Seyed,Ali-Reza Abdali-Mashhadi,Amin Lotfi,Ashraf Direkvand-Moghadam,Ali Delpisheh
- مشاهده
- جایگاه : پژوهشی
- مجله: Advanced Herbal Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Walnut,Juglans regia L,fatty acids,DPPH,Genotype
- چکیده:
- چکیده انگلیسی: Background and aims: Walnuts are good sources of polyunsaturated fatty acids (PUFA) and polyphenols which have beneficial effects such as proper growth, decreasing coronary heart disease, prevention of several kinds of cancer, anti-inflammatory and anti-mutagenic activities. In this study, the fatty acid content and antiradical activity of different walnut (Juglans regia L.) genotypes grown in Kolyaei region located in Kermanshah Province (Iran) were investigated. Methods: In this experimental study, fatty acid compositions in different genotypes of Persian walnut were determined using a GC–FID coupled with a flame ionization detector. For antiradical activity, methanolic extracts of different genotypes affected on DPPH (2, 2-diphenyl-1-picrylhydrazyl) radical. BHA (2-tert-butyl-4-methoxyphenol) was used as the reference compound. Results: Total oil content of walnuts ranged from 63.3 to 78.5%. Oleic acid, linoleic acid, linolenic acid, palmitic acid and stearic acid contents ranged respectively from 17.9 to 28.6%, 46.9 to 56.8%, 10.8 to 13.9%, 5.5 to 7.2% and 2.0 to 3.9%, while trace amounts of other fatty acids (<0.1% each) were detected in the samples. The results demonstrated that fatty acid composition is genotype dependent and the highest amounts of PUFA (due to the high content of linoleic acid) were observed in B2 genotype. Among different studied genotypes, the extract of B2 had also the highest radical scavenging activity and therefore the lowest EC50. Conclusion: It was concluded that pellicle is a necessary protecting layer that can help to inhibit the oxidation of fatty acids.
- انتشار مقاله: 17-05-1393
- نویسندگان: Vali Akbari,Reza Heidari,Rashid Jamei
- مشاهده
- جایگاه : پژوهشی
- مجله: Advanced Herbal Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Candida albicans,Antifungal activity,Honey,Clotrimazol
- چکیده:
- چکیده انگلیسی: Background and aims: Candida albicans is the most common cause of Vulvovaginitis Candidiasis that is the most common vaginitis in human. It is estimated that more than 90% of these infections are caused by Candida albicans. Medical treatment for these infections is carried out with chemotherapeutic drugs such as azoles. The increasing resistance of C. albicans to the azoles as well as their probable side effects is public concerns. Therefore, research for new natural component having antifungal activity has been considered to be very important. This study was designed to compare the effect of honey and clotrimazole against Candida albicans isolated from vagina and standard strain. Methods: In this clinical trial study, Samples of vaginal discharges were prepared from 100 women with vulvovaginitis candidiasis. Isolation and complete identification of Candida species were performed andthe suspension of Candida albicans prepared for insemination. Different concentrations of honey and clotrimazol were prepared and 10 µl of yeast suspension was added and incubated. Then 10 µl of these medium was cultured. Finally, the number of yeasts was counted and MIC50 and MIC90 were determined in comparison with positive control. Results: Different concentrations of honey and clotrimazol inhibited the growth of Candida albicans. In MIC 50 the mean concentrations of honey and clotrimazol were 1.15±0.49 g/ml and 60.26± 6.24 µ g/ml respectively. In MIC 90 the mean concentrations of honey and clotrimazol were 3.10± 3.15 g/ml and 2.38±2.36µ g/ml respectively. This means that honey in 3.10 g/ml concentration had the same effect as clotrimazol with concentration of 2.38µ g/ml. Conclusion: Honey markedly inhibited the growth of Candida albicans and its effect was comparable to cloitrimazol.
- انتشار مقاله: 06-05-1393
- نویسندگان: Shayeste Banaeian-Burojeni,Simin Taghipoor
- مشاهده
- جایگاه : پژوهشی
- مجله: Advanced Herbal Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Medicinal herbs,Celery,Antioxidant Activity,Therapeutic Uses,Compounds
- چکیده:
- چکیده انگلیسی: Background and aims: Medicinal plants are used in traditional medicine to treat many diseases. Celery (Apium graveolens) is a native medicinal plant to Europe. This plant has a very wide range of usage and cultivation. The wild type was found in countries such as Algeria, the Caucasus, Iran, India and America. However, due to increasing value and the special place of the plant in the new pharmaceutical industry, it is necessary to recognize the potential in the field of manufacturing and processing. This article presents morphological characteristics, vegetation compounds and evaluation of the therapeutic properties of this valuable medicinal plant. Methods: The information of this review article have been gathered from accessible journals in databases such as Web of Science, PubMed, Scopus, Embase, SID and Iran Medex. The search terms were "Celery" and "Apium graveolens" that searched in Persian and English books on medicinal plants and traditional medicine, as well as reputable sites mentioned. Results: Various studies have shown that Celery plays a role in prevention of cardiovascular disease, lowering blood glucose and serum lipid, decrease blood pressure and strengthener the heart. This herb has anti- bacterial, anti-fungal and anti- inflammatory effects. Also, a powerful antioxidant property has been attributed to compounds such as apigenin, apiein, vitamins A and C. Conclusion: Celery widely used in pharmaceutical, food and ornamental industries, that causes its significant commercial value. Various combinations and numerous medicinal properties of seeds, leaves and stems, cause the need further and more research about the other useful and unknown properties of celery.
- انتشار مقاله: 23-05-1393
- نویسندگان: Wesam Kooti,Sara Ali-Akbari,Majid Asadi-Samani,Hosna Ghadery,Damoon Ashtary-Larky
- مشاهده
- جایگاه : پژوهشی
- مجله: Addiction and Health
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Abstract Background: To determine the effect of opium smoking cessation on the frequency and type of microorganisms in the nasopharynx of opium smokers. Methods: This was a cross-sectional study performed in psychology and ENT department of Moradi Hospital of Rafsanjan University of Medical Sciences in 2008 (Kerman, Iran). Nasopharyngeal cultures were taken from 50 opium smokers before and 2 to 3 months after cessation of opium smoking. Potential pathogens were identified. Findings: Eight potential pathogens were isolated from nasopharyngeal cultures obtained from 43 individuals before opium smoking cessation, and 4 were recovered from 33 individuals after cessation (P < 0.0001). Streptococcus pneumonia, staphylococcus saprofiticus, streptococos α hemolytic, and staphylococcus aureus in 2nd culture were not seen. The most sensitivity to antibiotics was related to ceftriaxone (84%), ciprofloxacin (74%) and cloxacillin (72%); the most resistance was to amoxicillin (26%) and the least resistance was to chloramphenicol. Conclusion: In our study, some potential pathogens decreased or even disapeared after opium cessation. Our patients have not been advised to change their number of cigarettes. We have used methadone pill for substitution of opium. It seems that opium smoking affects nasopharyngeal flora. Keyword: Opium, Nasaopharynx, Microbial flora
- انتشار مقاله: 17-08-1389
- نویسندگان: Ali Golshiri,Mohammad Reza Mokhtaree,Ziba Shabani,Sayed Taghi Tabatabaee,Amir Rahnama,Mohammad Moradi,Ahamad Reza Sayadi,Hadi Faezi
- مشاهده
- جایگاه : پژوهشی
- مجله: Addiction and Health
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Abstract Background: Lycanthropy is an unusual belief or delusion in which the patient thinks that he/she has been transformed into an animal. In rare cases, the patient believes that another person has been transformed into an animal. Case Report: We report a patient with an uncommon variant of lycanthropy is introduced. The symptoms appeared after consumption of ecstasy. This shows the occurrences of uncommon and rare psychosis after ecstasy drug use especially in patients susceptible to schizophrenia. Ecstasy drug can induce paranoid psychosis similar to schizophrenia. In the presented case, ecstasy seemed to have a role in patient's underlying susceptibility to schizophrenia. Keywords: Lycanthropy, Ecstasy
- انتشار مقاله: 17-08-1389
- نویسندگان: Mansoureh Nasirian,Nabi Banazadeh,Ali Kheradmand
- مشاهده
- جایگاه : پژوهشی
- مجله: Addiction and Health
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Abstract Background: Stroke is the third cause of mortality and not only leads to dependency, which is a great social, individual and cultural problem, but also can affect the physiology, immune system and coagulation system such as plasma fibrinogen, and it may potentially increase the risk of stroke. This study investigated the relationship of opium dependency and stroke. Methods: This case- control study was carried out in 2003-2004 in Shefa Hospital in Kerman, Iran. The case group included 105 stroke patients and control group included the same number of patients from urology ward. There were 55 females and 50 males in each group. Patients' data were collected through their medical history, physical examinations, and diagnosis procedures recorded in specific questionnaires. Data were analyzed using Chi square test. Findings: 31 patients (29.5%) in the case and 11 (10.5%) in the control group were opium dependent and the difference was significant (P = 0.001). The relationship of cigarette smoking and stroke was also significant (P = 0.0001). To find the independent effect of each of these two factors, a logistic regression analysis was done, which showed that the independent relationship of each of these two was significant (Odds ratio = 2.207, P = 0.012 and Odds ratio = 2.36, P = 0.040 for cigarette and opium dependency respectively). Conlusion: Opium dependency can be regarded as an independent risk factor for stroke. As this corresponds to previous findings as to opium dependency can increase plasma fibrinogen and development of atherosclerosis, it is important for prophylactic manages. Keyword: Drug dependency, Opium, Stroke
- انتشار مقاله: 17-08-1389
- نویسندگان: Akbar Hamzei Moqaddam,Seyyed Mohammad Reza Ahmadi Musavi,Khatereh Khademizadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Addiction and Health
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Abstract Background: Tramadol is a centrally acting opioid analgesic used to treat moderate to sever pain. It has more advantage and less opioid adverse effects than conventional opioid analgesia. Case Report: This article reports a patient with tramadol dependency that had psychosis after tramadol withdrawal. Conclusion: By the increase of tramadol usage for relief of chronic pain, tramadol abuse and dependency is increased. Some of tramadol withdrawal symptoms are not related to opioid, for example when the effectiveness is not only on opioid receptors, but on catecholamine and serotonin receptors. So, together with typical symptoms of withdrawal, atypical symptomes had been reported. Psychosis is one of tramadol atypical withdrawal symptoms which subsided a few days after suppression of withdrawal symptoms. In such cases, the diagnosis is substance withdrawal instead of psychotic disorder due to substance withdrawal and treatment is based on this diagnosis. Keywords: Tramadol, Psychosis, Atypical withdrawal
- انتشار مقاله: 17-08-1389
- نویسندگان: Ghodratolah Rajabizadeh,Ali Kheradmand,Mansoureh Nasirian
- مشاهده
- جایگاه : پژوهشی
- مجله: Addiction and Health
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Abstract Background: Methadone maintenance therapy is a treatment of choice for opiate addiction. Understanding opiate dependents’ experiences of patients' treatment is a key to continue the treatment and can provide help to revise the standards of methadone centers and improve the quality of treatment. This study aimed to describe the essence and structure of opiate dependents’ experiences with methadone maintenance therapy. Methods: It was a qualitative phenomenological study, in which participants were selected from opiate dependents referred to methadone centers in Kerman city in 2007. Sampling was purposive and continued until data saturation, which was achieved at 32 participants. Data were collected by in-depth interviews. Colaizzi's method was applied for data analysis. The rigor of the present study was assessed based on the criteria of confirmability and credibility. Findings: A total of 26 themes were extracted and categorized into three main themes including positive therapeutic alliance, negative therapeutic alliance and therapeutic alliance requests. Conclusion: Client–centered therapy in methadone clinics creates a positive therapeutic alliance, and persuades patients to continue their treatment. Establishing a good relationship with patients during their treatment procedure is an effective way to meet the goals. Individual and group counseling sessions and advices on family and career related issues during the treatment should be considered as well. Keywords: Methadone, Experiences, Professional Patient Relationships, Qualitative research, Opiate dependence
- انتشار مقاله: 17-08-1389
- نویسندگان: Nabi Banazadeh,Ali Kheradmand,Heidarali Abedi
- مشاهده
- جایگاه : پژوهشی
- مجله: Addiction and Health
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Abstract Background: Opium dependency is an important health problem in Iran. Several studies show that most opium dependent patients have concomitant psychiatric disorders. The aim of this study was evaluation of psychiatric disorders in opium dependency in comparison with heroin dependency. Methods: This is a descriptive study on 192 male opium dependent patients who were admitted in dual- diagnosis ward of Beheshti Hospital in Kerman for detoxification. After evaluation of their demographic data, they were assessed by means of SCL-90-R test. Findings: The mean age of subjects was 33.92 ± 7.67 years. All scales of SCL-90-R were evaluated as borderline or sick. The scores of obsession-compulsion, anxiety, phobia, psychosis, PST, and GSI were significantly higher in heroin dependents compared to opium dependent patients (P < 0.05). Conclusion: It is recommended that all patients with opium dependency should be evaluated for co-morbid psychiatric disorders. This may improve the outcome and management of their dependency. Keywords: Opium, Heroin, Psychopathology, SCL-90-R
- انتشار مقاله: 17-08-1389
- نویسندگان: Alireza Ghaffari Nejad,Hassan Ziaadini,Nabi Banazadeh
- مشاهده