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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Women’s Health Bulletin
- نوع مقاله: Journal Article
- کلمات کلیدی: Women,Breast cancer,Efficacy,self
- چکیده:
- چکیده انگلیسی: Background: Self-efficacy refers to an individual’s belief in his or her capacity to execute behaviors necessary to produce specific achievement. Past studies have shown probable increases in self-efficacy with growing age. Iranian women with breast cancer are one decade younger than their western counterparts. Objectives: The present study aims to investigate the level of cancer-related self-efficacy in Iranian women, and its demographic and medical predictors. Patients and Methods: This is a descriptive cross-sectional study comprised of 91 breast cancer patients referring for chemotherapy to one of the largest oncology centers in northwest of Iran. The patients’ demographic and medical characteristics were determined and their cancer related self-efficacy was assessed using cancer behavior inventory containing 33 items. Data analysis was completed using SPSS software version 13. Descriptive and Regression analysis were used to describe demographic and medical characteristics of the patients and their predictors of cancer-related self-efficacy. Results: The sustained cancer-related positive attitude had, in total, the highest mean score of 7 subscales of cancer behavior inventory and the seeking of social support had the least mean score. Only Patient’s education and the time of cancer diagnosis were associated with self-efficacy of Iranian women in relation to cancer. Conclusions: According to the results obtained, it is necessary to consider the level of education, social support, and the time of cancer diagnosis in order to assess the self-efficacy in Iranian women with breast cancer.
- انتشار مقاله: 11-10-1348
- نویسندگان: Zahra Kochaki Nejad,Alireza Mohajjel Aghdam,Hadi Hassankhani,Mohammad Asghari Jafarabadi,Zohreh Sanaat
- مشاهده
- جایگاه : پژوهشی
- مجله: Middle East Journal of Cancer
- نوع مقاله: Journal Article
- کلمات کلیدی: Quality of Life,cancer,chemotherapy,patients
- چکیده:
- چکیده انگلیسی: Background: Chemotherapy is an important treatment for cancer, yet some of its side effects are serious and painful. Many patients with cancer suffer from psychiatric disorders that most likely result from therapeutic drugs or mental strategies to cope with their illness. Progressive muscle relaxation is one of the cost effective, self-help methods that promotes mental health in healthy participants. This study aims to determine the effect of progressive muscle relaxation training on anxiety and depression in cancer patients undergoing chemotherapy. Methods: This was a randomized, clinical study that enrolled 60 patients who received inpatient chemotherapy in the Tabriz Hematology and Oncology Research Center in 2010. We divided patients into two groups, intervention and control. All participants signed written formal consents and completed the Hospital Anxiety & Depression Scale questionnaires. Intervention group participants were trained in progressive muscle relaxation in groups of 3-6 to enable participants to perform this technique when they were alone in the hospital and after discharge, two to three times each day. After one and three months, questionnaires were completed again by both groups and the results compared. 17th version of SPSS software was used for data analysis. Results: After data analysis, most participants were satisfied with learning and experiencing this technique. There was no significant difference between scales in the case and control groups after one month (P>0.05). However after three months, anxiety and depression considerably improved in patients who underwent progressive muscle relaxation training (P<0.05). Conclusion: Progressive muscle relaxation training can improve anxiety and depression in cancer patients.
- انتشار مقاله: 09-07-1392
- نویسندگان: Sepideh Herizchi,Iraj Asvadi,Isa Piri,Mehri Golchin,Reza Shabanlui,Zohreh Sanaat
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Colorectal cancer,Gene expression,caspase,mRNA level
- چکیده:
- چکیده انگلیسی: Background: Caspases proteins are protease enzymes involved in the initiation and execution of apoptosis process.
Regulation of apoptosis process plays an important role in the normal biological events and development. In addition
to developmental abnormalities, dysregulated apoptosis system may lead to tumorigenesis, autoimmunity, and other
serious health problems. Aberrant regulation of apoptosis may also be the paramount cause of chemoresistance during
cancer therapy. It is aimed through this study to evaluate the transcript levels of Caspase 3, 8, and 9 in tumoral tissues
from patients with colorectal cancer (CRC) and compare it with normal marginal tissues. Methods: Fifty tumor tissues
and their matched marginal tissues, as control group, were obtained from CRC patients. Total mRNA of all tissue
samples was extracted and cDNA was synthesized. Using SYBR Green PCR master mix and Real-time gene expression
technique, the transcript level of target genes was quantified. Results: Experiments indicated that mRNA expressions
of caspase 9 and 3 were downregulated in tumoral tissues from CRC patients in comparison to marginal tissues. In
contrast, tumoral tissues expressed mRNA of caspase 8 higher than normal marginal tissues. Modified transcript levels
of caspase 3, 8, and 9 were correlated with the clinical manifestations of the patients. Conclusions: Alteration in the
mRNA level of caspase genes may be involved in the development of CRC.- انتشار مقاله: 25-07-1396
- نویسندگان: Milad Asadi,Dariush Shanaehbandi,Touraj Asvadi Kermani,Zohreh Sanaat,Venus Zafari,Shahriyar Hashemzadeh
- مشاهده