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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: cancer,Diabetes Mellitus,Delta-6-Desaturase,mTOR,Multiple Sclerosis
- چکیده:
- چکیده انگلیسی: Background: The phosphatidylinositol 3-kinase/ protein kinase B /mammalian target of rapamycin (PI3K/Akt/
mTOR) signaling regulates multiple cellular processes and organizes cell proliferation, survival, and differentiation
with the available nutrients, in particular, fatty acids. Polyunsaturated fatty acids (PUFAs) are cytotoxic to cancer cells
and play a critical role in the treatment of multiple sclerosis (MS) and diabetes mellitus (DM). PUFAs are produced in
the body by desaturases and elongases from dietary essential fatty acids (EFAs), primarily involving delta-6-desaturase
(D6D). D6D is a rate-limiting enzyme for maintaining many aspects of lipid homeostasis and normal health. D6D is
important to recognize the mechanisms that regulate the expression of this enzyme in humans. A lower level of D6D was
seen in breast tumors compared to normal tissues. Interestingly, the elevated serum level of D6D was seen in MS and
DM, which explains the critical role of D6D in inflammatory diseases. Methods: We searched databases of PubMed,
Web of Science (WOS), Google Scholar, Scopus and related studies by predefined eligibility criteria. We assessed
their quality and extracted data. Results: Regarding the mTOR signaling pathway, there is remarkable contributions of
many inflammatory diseases to attention to common metabolic pathways are depicted. Of course, we need to have the
insights into each disorder and their pathological process. The first step in balancing the intake of EFAs is to prevent
the disruption of metabolism and expression of the D6D enzyme. Conclusions: The ω6 and ω3 pathways are two major
pathways in the biosynthesis of PUFAs. In both of these, D6D is a vital bifunctional enzyme desaturating linoleic acid
or alpha-linolenic acid. Therefore, if ω6 and ω3 EFAs are given together in a ratio of 2: 1, the D6D expression will be
down-regulated and normalized.- انتشار مقاله: 04-07-1397
- نویسندگان: Zhila Arshad,Soheila Rezapour-Firouzi,Meysam Ebrahimifar,Alireza Mosavi-Jarrahi,Mahshid Mohammadian
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: cancer,Allergy,Polyunsaturated fatty acids,Immune response,Thelper
- چکیده:
- چکیده انگلیسی: Background: Disturbance in essential fatty acids (EFA) metabolism plays a key role in autoimmune diseases, but
EFA supplementation with sources of borage, evening primrose, hemp seed and fish oils was not effective in atopic
and cancer diseases, as that seen in the case of multiple sclerosis. It seems that two complexes of the mammalian target
of rapamycin (mTOR) signaling, mTORC1 and mTORC2, are congruent with the two bases of the Traditional Iranian
Medicine (TIM) therapy, Cold and Hot nature, which are essential for the efficacy of functional oils for controlling
immune responses in autoimmune diseases. Methods: We searched PubMed database, Web of Science (WOS), Google
Scholar, Scopus and selected studies by predefined eligibility criteria. We then assessed their quality and extracted data.
Results: The oils controlled by Cold or Hot nature may be helpful in maintaining homeostasis and preventing autoimmune
diseases. In summary, studies of randomized controlled trials for allergy and cancer patients found no improvement
in the signs or response to tests, despite a remarkable change in EFA fractions in the blood by supplementation with
sources of borage, evening primrose, hemp seed and fish oils. In contrast, portulaca oleracea oil exhibited protective
effects by anti-inflammatory properties via the PI3K/Akt/mTORC2 pathway with a deviation immune response to Th1
to treat atopic diseases and cancer. Conclusions: According to the concept of Traditional Iranian Medicine therapy, in
contrast to Cold-nature oils, EFA supplementation with the sources of Hot-nature oilsis not suitable for the treatment
of atopic and cancerous diseases.- انتشار مقاله: 05-03-1397
- نویسندگان: Zhila Arshad,Soheila Rezapour-Firouzi,Mahshid Mohammadian,Meysam Ebrahimifar
- مشاهده