در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Pathology,staging,Liver biopsy,Inter-observer,grading
- چکیده:
- چکیده انگلیسی: Background & Objective: Liver biopsy is the main method for grading and staging liver disorders, but the effects of clinical information and optimal biopsy specimen size on interpretation remain contentious. The aim of the study was to evaluate the impact of clinical information and quality of liver specimen on inter-observer agreement for liver disease.
Methods: A total of 289 consecutive biopsy specimens from 2010 to 2017 were re-evaluated by five pathologists using the modified Ishak and non-alcoholic fatty liver diseases (NAFLD) activity score (NAS) systems. Detailed clinical information was extracted from medical records of patients and the size of all liver biopsy samples was recorded.
Results: Full agreement between primary diagnosis and final diagnosis was obtained in 214 cases (74%). The remaining cases, namely 22 (7.6%) and 53 (18.3%) biopsies had minor and major diagnostic discrepancies, respectively. The results showed that the overall agreement was significantly higher in cases with complete clinical information than patients without any clinical information and even with partial clinical information (P<0.001). Interestingly, no significant difference in inter-observer agreement was achieved with a length over 20 mm (P=0.181). However, the inter-observer variation significantly decreased when the number of portal tract was more than 10 (P=0.001).
Conclusion: This study identified the impact of clinical information and the number of portal tracts as the key factors to diagnosis. Therefore, request forms for liver biopsies should always be accompanied with the clinical history. Moreover, adequacy of biopsy specimens is very useful for accurate evaluation of samples by pathologists.- انتشار مقاله: 27-09-1397
- نویسندگان: Zeinab Kishani Farahani,Mahsa Ahadi,Behrang Kazeminejad,Tahmineh Mollasharifi,Malihe Saber Afsharian,Amir Sadeghi,Farahnaz Bidari Zerehpoosh,Elena Jamali,Niki Hasanzadeh,Abolfazl Movafagh,Arash Dehghan,Arsham Moradi,Afshin Moradi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Biotechnology
- نوع مقاله: Journal Article
- کلمات کلیدی: Diagnosis,Pollen,low-cost technology,colloidal silver nano particles
- چکیده:
- چکیده انگلیسی: Background: Nanoparticles have been applied to medicine, hygiene, pharmacy and dentistry, and will bring significant advances in the prevention, diagnosis, drug delivery and treatment of disease. Green synthesis of metal nanoparticles has a very important role in nanobiotechnology, allowing production of non-toxic and eco-friendly particles.
Objectives: Green synthesis of silver nanoparticles (AgNPs) was studied using pine pollen as a novel, cost-eff ective, simple and non-hazardous bioresource. The antifungal activity of the synthesized AgNPs was investigated in vitro.
Materials and Methods: Biosynthesis of AgNPs was conducted using pollen of pine (as a novel bioresource) acting as both reducing and capping agents. AgNPs were characterized using UV-visible spectroscopy, X-ray diff raction and transmission electron microscopy. In evaluation for antifungal properties, the synthesized AgNPs represented signifi cant in vitro inhibitory effects on Neofusicoccum parvum cultures.
Results: Pine pollen can mediate biosynthesis of colloidal AgNPs with an average size of 12 nm. AgNPs were formed at 22C and observed to be highly stable up to three months without precipitation or decreased antifungal property. AgNPs showed signifi cant inhibitory eff ects against Neofusicoccum parvum.
Conclusion: The first report for a low-cost, simple, well feasible and eco-friendly procedure for biosynthesis of AgNPs was presented. The synthesized AgNPs by pine pollen were nontoxic and eco-friendly, and can be employed for large-scale production. The nanoparticles showed strong eff ect on quantitative inhibition and disruption of antifungal growth.- انتشار مقاله: 15-10-1394
- نویسندگان: Mehrdad Khatami,Seyed Mojtaba Mortazavi,Zeinab Kishani Farahani,Abbas Amini,Elham Amini,Hossein Heli
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Colorectal polyps,adenomatous polyps,Serrated polyps,non-neoplastic polyps
- چکیده:
- چکیده انگلیسی: Aim: This study was designed to report epidemiologic findings of polyps in Iranian patients, and predict histology of polyp regarding to demographic and colonoscopic findings. Background: Classification of colorectal polyps had been revised in the past two decades and there is a need for polyp categorization in the Iranian Health System. Patients and methods: In this retrospective study, the medical records of patients with colonoscopic diagnosis of polyp in pathology departments of SBMU affiliated teaching hospitals were reviewed. Patient’s slides evaluated and demographics findings were assessed. The anatomical location, macroscopic appearance including size and histological assessment of all polyps were recorded. Results: From total number of 1106 polyps (detected in 862 patients), adenomatous polyps (638 [57.7%]) were the most prevalent findings, followed by colon mucosal tag (184[16.6%]), hyperplastic and serrated polyps (122[11%]), inflammatory polyps (110[9.9%]), hamartomatous (21[1.9%]), and malignant lesions (13[1.2%]). Multivariate logistic regression showed age (each one year increasing age; odds ratio [OR] = 1.026, 95%confidence interval [CI] = 1.016–1.036, p < 0.0001), location of polyp (right colon; OR = 1.905, 95%CI = 1.366–2.656, p < 0.0001), and polyp size of 5-10 mm (OR = 1.662, 95%CI = 1.214–2.276, p = 0.002), and polyp size of >10 mm (OR = 2.778, 95%CI = 1.750–4.411, p< 0.0001) were independently associated with neoplastic polyps. Also, polyp size of >10 mm (OR= 2.613, 95%CI= 1.083-6.307, p=0.033), tubulovillous pattern of polyp (OR= 3.508, 95%CI= 1.666-7.387, p=0.001) and villous pattern of polyp (OR= 10.444, 95%CI= 4.211-25.905, p
- انتشار مقاله: 23-08-1397
- نویسندگان: Mahsa Ahadi,Behrang Kazemi Nejad,Zeinab Kishani Farahani,Tahmineh Mollasharifi,Elena Jamali,Hamid Mohaghegh Shalmani,Arash Dehgan,Maliheh Saberi Afsharian,Amir Sadeghi,Abolfazl Movafagh,Roxana Boran,Azadeh Rakhshan,Arsham Moradi,Mohammad Hassan Heidari,Afshin Moradi
- مشاهده