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- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Probiotics,lipid profile,ALT,Non-Alcoholic fatty liver disease
- چکیده:
- چکیده انگلیسی: Background: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease which is correlated with overweight, obesity, and insulin resistance. Recently, the use of probiotics has been suggested for these patients as they have considerable outcomes. The aim of the present study is to evaluate the effect of GeriLact on patients with NAFLD. Method: In this randomized clinical trial, 61 patients with NAFLD were recruited and randomly assigned to groups receiving GeriLact, 500 mg, twice per day, or placebo (with the same dose) for sixty days. Weight, body mass index (BMI), lipid profile, fasting blood sugar (FBS), Alanine aminotransferase (ALT), Aspartate Aminotransferase (AST), and sonographic grading were evaluated before and at the end of the study. Results: In the GeriLact group, there was a significant decrease in ALT (p=0.002) and AST (p<0.001) levels, while the placebo group showed a significant decrease only in ALT level (p=0.01). There was a significant decrease in cholesterol levels in the intervention group compared to the placebo group (p=0.01), but there were no significant changes in FBS, triglycerides, LDL, and HDL levels between the two groups. The fatty liver grade was improved by 63.6% in the intervention group and by 46.4% in the placebo group. Conclusion: The results showed that probiotics caused significant improvement in ALT, AST, and cholesterol levels but had no effects on FBS, triglycerides, low-density lipoprotein (LDL), and high-density lipoprotein (HDL). Overall, treatment with GeriLact was found to be effective, safe, with low cost and well-tolerated in the long term use by the patients.
- انتشار مقاله: 22-02-1398
- نویسندگان: Mohammad Sadrkabir,Shirin Jahed,Zahra Sadeghi,Khatereh Isazadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: risk factors,Iran,Prevalence,Coronary Artery Disease,Kerman,Municipal regions
- چکیده:
- چکیده انگلیسی: Abstract Background and Aims: Cardiovascular diseases (CADs) are the most important causes of mortality and morbidity in the world and in Iran. These diseases are not completely curable but factors affecting them are preventable. The aim of this study was investigation of CAD risk factors in four municipal regions of Kerman city.
Methods: From the city postal codes, 250 postal codes (as clusters) were selected randomly. Research coordinator team attended households in clusters and all the eligible members were recruited to the study. The recruitment was continued to reach 24 subjects in each cluster. The sample size was 5900 individuals aged from 15 to 75 years old. The prevalence of CAD risk factors including diabetes, hypertension, overweight and obesity, low physical activity, hyperlipidaemia, cigarette and opium smoking, depression and anxiety, oral and dental hygiene were assessed.
Results: Overweight with overall prevalence of 30.5% in the city, showed significant different prevalence rates in four regions (region 1: 29.9%, region 2: 33.8%, region 3: 29.7% and region 4: 30.5%, P<0.001). Overall, diabetes and hypertension had prevalence rates of 8.1% and 11.3%, both with similar distribution in the four regions. However, in diabetic patients, the prevalence of abnormal HbA1C was 67.3%, 50.2%, 70.4% and 45.1% in regions one to four respectively (P<0.0005). The region four with 15.4% opium consumption had the highest rank among the four regions. Depression and anxiety had the highest prevalence in region 4 and the lowest in region 2 (P<0.01). The gingival score index was 72.6% in men and 68.1% in women with region four having the maximum prevalence of 80.1%.
Conclusion: Overall, the prevalence of CADs in Kerman is relatively high and differs based on the region. Therefore, it is recommended that in designing educational programs for improving health behaviours, those differences are considered. It is suggested that these educations persist on reduction of obesity, opium consumption and improvement of mental health in region 4, on weight and LDL reduction in region 2, on diabetes control in regions 1 and on mental health improvement in region 3.- انتشار مقاله: 21-08-1394
- نویسندگان: Hamid Najafipour,Majid Askaripour,Ali Hosseinzadeh,Zahra Sadeghi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Sol-Gel,Dip-Coating,Crystalization,Nano Hydroxyapatite
- چکیده:
- چکیده انگلیسی: This article describes the preparation and analysis of nano hydroxyapatite (HA) films on stainless steel 316L through sol-gel technique. The process started with preparation of a nitrate and phosphate sol. After aging the sol for 24 h at room temperature a SS316 substrate was dip-coated and heat-treated at 350 to 450 °C for different times in air. The coating phase and structure on substrate were investigated by X-ray diffraction (XRD), fourier transform infrared (FT-IR), differential thermal analysis (DTA) and scanning electron microscopy (SEM). Degree of crystallinity and time temperature transformation (TTT) diagram of HA films obtained with using Avrami equation. Results indicated that HA phase began to crystallize after a heat treatment at 250 °C and the crystallinity increased at a temperature of 450 °C. The HA film showed a nano structure with suitable crystallinity after heat treatment.
- انتشار مقاله: 16-09-1386
- نویسندگان: Hossein Najafi,Ziarat Ali Nemati,Zahra Sadeghianb,Nafiseh Sohrabi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Microstructure,Zirconia,Ceramic body,Gelcasting
- چکیده:
- چکیده انگلیسی: Bioinert ceramics, like alumina and zirconia are used mainly for replacements of bones, hip joints and for dental implants. Partially stabilized zirconia ceramics (PSZ or TZP with 3 mol.% or 5 wt.% Y2O3), appear as perspective bioinert ceramics because of their high strength and corrosion resistance. In order to fabricate complex shapes, it is essential to use a near net shape processing like gelcasting as an uncomplicated method which has appropriate potential of producing special shapes with suitable green and sintered properties (like high mechanical properties and almost full density and machinability of green bodies). Moreover, biocompatibility studies have proved that this processing route is nontoxic. In this experiment, micro-structural observation performed to illustrate the effect of dispersant on homogeneity of gelcast 3Y-TZP bodies. It has been shown that it is possible to achieve uniform microstructure by means of appropriate amount of dispersant and ultrasonic wave. In addition, the machinability of these green bodies has been proven and some complex shaped bodies fabricated, in order to illustrate the capability of the process.
- انتشار مقاله: 16-09-1386
- نویسندگان: Nasim Sahraei Khanghah,Mohammad Ali Faghihi Sani,Alireza Kamali,Zahra Sadeghian
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: DPPH,Antioxidants,FRAP,Total phenolic content,Boerrhavia elegans
- چکیده:
- چکیده انگلیسی: Objective: Boerhaavia elegans L. (Nyctaginaceae) is a medicinal plant used for the treatment of kidney disorders, urinary tract disorders and blood purification in Baluch tribe. The aim of present study is to evaluate the antioxidant propertyof B. elegans species for the first time.
Materials and Methods: Different parts (leaf, stem and fruit) of the plant were extracted by using various solvents (water, methanol, chloroform and ethyl acetate) and evaluated for their antioxidant activity using DPPH (2, 2-diphenyl-1 picryl hydrazyl) and FRAP (ferric reducing antioxidant power) methods. In addition, total phenolic content was determined by Folin–Ciocalteu reagent.
Results: Antioxidant results were expressed as IC50. The antioxidant power in DPPH and FRAP assay were evaluated as shown in decreasing order: Methanolic extract > Aqueous extract > Ethyl acetate extract > Chloroform extract, for all parts of the plant. In both methods of antioxidant assay and Folin-Ciocalteu method, methanolic extract of leaf exhibited the highest activity and the most phenolic content IC50= 6.85ppm and 16.41 mg GA/g d w respectively. Total phenolic content had a positive relationship with antioxidant capacity in extracts and there was a high correlation (r=1.00, p<0.01) between antioxidant activities as determined by both antioxidant assays for various parts.
Conclusion: The results of the experiments showed that B. elegans extract had significant antioxidant effects. This high antioxidant activity may be linked to phenolic contents of the plant but complementary investigations are suggested in order to determine active elements.- انتشار مقاله: 24-12-1392
- نویسندگان: Zahra Sadeghi,Jafar Valizadeh,Omid Azyzian Shermeh,Maryam Akaberi
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Therapeutics,Traditional medicine,Phytochemistry,toxicity,Otostegia,Pharmacology
- چکیده:
- چکیده انگلیسی: Abstract
Objective: The current study summarizes the updated information concerning the ethnopharmacology, Phytochemistry, and pharmacology of Otostegia persica Boiss. (Lamiaceae), an endemic medicinal plant in south and southeast of Iran.
Materials and Methods: Information was collected through bibliographic investigation from scientific journals, books, theses, reports, and electronic search (databases SCOPUS, Google Scholar, Web of Science, and Science Direct). Moreover, documentation from unpublished resources and ethnobotanical surveys has been used. The present review covers the literature available from 2003 to 2013.
Results: In traditional systems of medicine, this plant is reputed for treating diabetes, arthritis, gastric discomfort, headache, rheumatism, sedative activities, regulating blood pressure, and hyperlipidemia. Phytochemical screening of active components and mineral element evaluation of this species have been reported. Several types of diterpenoids and flavonols including morin, kaempferol, and quercetin are identified from the plant. Most of the pharmacological activity of this plant resides in its flavonoid fraction which causes antimicrobial and antioxidant activities. Various pharmacological studies on O. persica show antimicrobial, antioxidant, anti-inflammatory, anti-diabetic, anti-aphid, and hepatoprotective activities.
Conclusion: Being an endemic plant of Iran, this species is an important medicinal herb which can be used for various purposes. This review might be helpful for scientists and researchers to find new chemical entities responsible for its claimed traditional uses and discover new lead compounds for diseases mentioned.- انتشار مقاله: 16-03-1392
- نویسندگان: Zahra Sadeghi,Maryam Akaberi,Jafar Valizadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of English Language Pedagogy and Practice
- نوع مقاله: Journal Article
- کلمات کلیدی: Discourse,The Novel,Characterization,Linguistic analysis,Systemic Linguistics,Teaching Language through Literature
- چکیده: رمان به عنوان ژانر ادبی مدرن معمولاً تجلی سیر شخصیت اصلی اثر از نابالغی به بلوغ تلقی می شود. شخصیت اصلی رمان که در ابتدا فرد ساده ای است که در مقابله با پیچیدگی های زندگی ناتوان است به تدریج فهم و ادراک حاصل می کند تا متعاقباً به شکلی درخور عمل کند. عموماً در نقد ادبی و نقد زبانشناختی ادبیات اتفاق نظر وجود دارد که شناخت شخصیت می بایست با توجه به عناصر متن رمان صورت گیرد (برای مثال ر.ک. فاولر 1977 و 1996، پک و کویل 2002). در این مقاله، زبان تام جود یعنی شخصیت اصلی رمان خوشه های خشم جان استاین بک تجزیه و تحلیل می شود تا روشن شود که چگونه وی از یک کارگر مزرعه ی سهل انگار جوان به مصلح اجتماعی آینده نگر بدل می شود. به دلیل رویکرد زبانشناختی به مطالعه ی ادبیات در این مقاله، زبانشناسی نقشگرای هلیدی چارچوب تحلیل بوده است. نتایج حاصل از این مطالعه می تواند در تدریس زبان انگلیسی از طریق ادبیات مفید باشد.
- چکیده انگلیسی: The novel as a modern literary genre is generally regarded as the realization of its main character's journey from immaturity to a status of maturity. The character, usually an uncomplicated person unable to cope with the complexities of life at first, gains an insight and understanding to handle his/her complex situation accordingly later in the novel. It is usually agreed in both literary criticism and linguistic criticism of literature that everything about a character should be established from the evidence of the text (see Fowler, 1977 & 1996 and Peck & Coyle, 2002, for instance). In the present study, the language of Tom Joad, the main character in John Steinbeck's The Grapes of Wrath, was analyzed to reveal how his social position is established and how his transformation from a young farm-hand holding a carpe diem philosophy to a socially-wise reformist with a commitment to bettering the future is substantialized. Oriented towards a linguistic study of literature, the present paper employsSystemic Functional Linguistics (SFL) as the analytic framework. The findings of the study may be useful especially for those involved in teaching English language through literature.
- انتشار مقاله: 31-03-1395
- نویسندگان: Bahram Behin,Zahra Sadeghi
- مشاهده