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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Apoptosis,Mice,Fumonisin B1,Gastric atrophy,Proliferative activity
- چکیده:
- چکیده انگلیسی: Objective(s):Fumonisins are a group of toxic and carcinogenic mycotoxins, which contaminate the grains and their products. The aim of this study was to examine the apoptotic and proliferative activity of mouse gastric mucosa following administration of fumonisin B1 (FB1).
Materials and Methods: Twenty-nine female mice divided into treatment (n=15) and control (n=14) groups. The treatment group received FB1 (150 mg/kg diet) for 16 weeks. The gastric atrophy was allocated using grading criteria modeled on the updated Sydney System. Immunohistochemistry studies were performed for evaluation of apoptosis and proliferative activity in gastric mucosa.
Results: Mild to moderate gastric atrophy were observed in microscopic findings of the gastric mucosa in treated animals (P<0.05). Number of parietal cells significantly decreased in the treatment group in comparison with the control (P<0.05). Treatment with FB1 for 16 weeks significantly reduced both gastric mucosa height and mitotic index in the gastric glands (P<0.05). TUNEL- and Bax-labeled positive cell numbers significantly increased in the FB1-treated group compared to the control (P<0.05). In addition, proliferative activity of gastric glands in the treated group was significantly lower than the control (P<0.05).
Conclusion: Oral administration of FB1 caused atrophy in gastric mucosa both via increasing of apoptosis and suppressing the mitotic activity of these cells.- انتشار مقاله: 06-11-1393
- نویسندگان: Ali Mohammad Alizadeh,Fahimeh Mohammadghasemi,Kazem Zendehdel,Zahra Kamyabi-moghaddam,Abbas Tavassoli,Fatemeh Amini Najafi,Alireza Khosravi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Chemistry and Chemical Engineering
- نوع مقاله: Journal Article
- کلمات کلیدی: Heterocycles,Bis-imidazole,One-pot reaction,Triaryl pyridine,Molecular tweezers
- چکیده:
- چکیده انگلیسی: In the present study, some new bis-imidazole derivatives have been prepared through four-components condensation of 2,6-bis (4-aminophenyl)-4-p-tolylpyridine, benzaldehyde derivatives, benzil and ammonium acetate in presence of acetic acid. The present methodology offers several advantages such as good yields, simple procedure, milder conditions and
the possibility of introducing a variety of substituents at different positions of the imidazole and pyridine rings. These new compounds were confirmed by spectral methods 1H NMR, 13C NMR, FT-IR, and elemental. Also, optimized geometries and chemical shifts have been calculated for the synthesized compounds using Density Functional Theory (DFT) method. Their optimized geometries are not planar.- انتشار مقاله: 18-10-1393
- نویسندگان: Hossein Behmadi,Zahra Amini Moghaddam,Narges Poormorteza,Safar Ali Beyramabadi,Maryam Arian Nezhad
- مشاهده
- جایگاه : پژوهشی
- مجله: Advances in Environmental Technology
- نوع مقاله: Journal Article
- کلمات کلیدی: Fuel oil hydrotreating,Steam power plant,Emissions control,Social cost savings,National and international SO2 emissions standards
- چکیده:
- چکیده انگلیسی: This work presents a simulation approach to the design and economic evaluation of fuel oil hydrotreating processes for the control of SO2 and NOx emission in an Iranian steam power plant. The percent of fuel oil desulphurization was estimated from the SO2 emissions standards for power plants. Based on two different scenarios according to (I) European and (II) Iranian standards, the design and simulation of hydrodesulphurization reactors, separation, heat recovery, and amine gas sweetening sections were performed and an economic assessment of the plant was investigated for each scenario. The results indicated the following: the cost price of each barrel of low sulfur fuel oil produced in such plants was estimated at 4.24 US$ for scenario (I) and 3.17 US$ for scenario (II); the levelized cost of desulfurization in power production was estimated at 0.618 c/kWh for (I) and 0.463 c/kWh for (II); and the social cost savings of replacing every barrel of low sulfur fuel oil instead of one barrel of high sulfur fuel oil were estimated at 26.7 US$ for (I) and 13.6 US$ (II).
- انتشار مقاله: 05-04-1395
- نویسندگان: Peiman Pourmoghaddam,Susan Davari,Zahra Moghaddam
- مشاهده