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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: International Journal of Molecular and Clinical Microbiology
- نوع مقاله: Journal Article
- کلمات کلیدی: aspirin,Real-time PCR,Fluconazole,Candida glabrata,ERG11
- چکیده:
- چکیده انگلیسی: Azole compounds have been a treatment option for Candida glabrata infections. However, azole resistance can occur through different mechanisms such as alterations in ERG11 (lanosterol 14α-demethylase). Aspirin (ASA), a non-steroidal anti-inflammatory drug, showed antimicrobial activity against Candida. The purpose of this study was to evaluate the synergistic effect of ASA as an anti-inflammatory drug with the fluconazole on the azole-resistant C. glabrata isolates. In the cross-sectional study, a total of 60 oral samples were collected from the school of dentistry, Tehran University of medical sciences. After confirmation of fungal isolates, template DNA was extracted and PCR for detection of Erg11 gene by specific primers was performed in all Fluconazole-resistant isolates. MIC for ASA was determined using broth dilution method in 96‐well plates. RNA was extracted and cDNA synthesized according to the Omniscript RT kit instructions. The effect of ASA in the treated and non-treated groups on ERG11 gene expression was determined by Real-Time PCR technique. Out of 60 collected samples, 12 (20%) C. glabrata were isolated. All of these isolates were resistant to fluconazole and carried ERG11 genes. Real-time PCR results showed that the combination of ASA with fluconazole reduced ERG11 gene expression. It is concluded that, treatment of candidal infections with ASA significantly reduced resistance in to azole compounds by down expression of ERG11 gene, suggesting that an NSAID might be useful for azole-resistance candidal infections.
- انتشار مقاله: 14-01-1398
- نویسندگان: Zahra Khosravi,Kumarss Amini,Mansour Bayat,Laya Takbiri Osgoei
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Infant,Nutrition, Unwanted pregnancy
- چکیده:
- چکیده انگلیسی: Background
The current study was conducted to investigate the relationship between unwanted pregnancy based on couples’ opinions and infant nutrition type in women referred to the health centers in Mashhad city and their husbands.
Materials and Methods
In this analytical-descriptive study, unwanted or wanted progenies were studied from the viewpoints of 366 women referred to the health centers in Mashhad city, Iran and their husbands, and also their relationships with infant nutrition type at the age of 4 months. The data were collected through questionnaires. The validity and reliability of the method and instruments were confirmed by content validity and test-retest. Moreover, data analysis was done using SPSS-16.0 software.
Results
The average age of women in wanted pregnancy was 26.43±4.57 years and 27.57±5.22 years in unwanted women. The results showed a statistically significant relationship between unwanted pregnancy from the viewpoints of couples and infant's nutritional status (P=0.03). The prevalence of unwanted pregnancy in women with lower education (middle and high school) was higher than those with higher education.
Conclusion
Our results showed a significant association between baby’s nutrition and unwanted pregnancy. Furthermore, an increased use of non-exclusive breastfeeding in unwanted pregnancy is necessary. Hence, proper use of contraceptive methods, preventing the adverse consequences of unwanted pregnancy such as non-exclusive breastfeeding, useful educational strategies, counseling and health services are necessary to be taken into account.- انتشار مقاله: 10-04-1395
- نویسندگان: Zahra Khosravi Anbaran,Nasrin Baghdari,Elahe Sadeghi Sahebzad,Maryam Moradi,Fatemeh Zahra Karimi
- مشاهده
- جایگاه : پژوهشی
- مجله: Canon Journal of Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Iraq,Tinnitus,Hearing loss,war
- چکیده:
- چکیده انگلیسی: Introduction: Determining distribution of war injuries and the related mechanisms could provide attitudes in order to lower risks and expenses of war injuries as well as mortality. Ear injuries are of a high importance among battle-related injuries because of their dramatic impressions on quality of life of militants. So we aimed to determine the mechanism and type of ear injuries among Iranian veterans during Iraq-Iran war.
Methods: In this cross-sectional study 207 cases of Iranian veterans with ear injuries during the Iraq-Iran war have been evaluated retrospectively between June and September 2016. We included veterans with ear injuries in association or absence of other organs injuries, randomly. Frequency and mechanism of injuries were recorded as well as chief complaints of patients. Mean, standard deviation and percentages were determined by descriptive analysis.
Results: Eventually 207 male veterans with mean age of 52.18±5.28 years were included in the study. Mean duration of war participation was 2.60±1.91 months. Shock wave was the most prevalent mechanism of injury with 202(97.6%) cases followed by direct bullet injury 3(1.4%) and blast injury (0.5%). Decreased hearing and vertigo were the most common (83%) chief complaint of patients followed by decreased hearing alone (56%) and tinnitus (2.9%).
Conclusion: Our findings showed that decreased hearing is the most prevalent pathology among Iranian veterans with ear injuries during Iraq-Iran war. Tinnitus did not comprise a remarkable part of chief complaints. Also we found that shock wave is the most prevalent mechanism of ear injury.- انتشار مقاله: 15-02-1398
- نویسندگان: Amir Hossein Ghazaleh,Zahra Khosravi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Quality of Life,Breast cancer,Iranian women
- چکیده:
- چکیده انگلیسی:
Introduction: Nowadays breast cancer is the most important factor concerning the women’s health which can affect the quality of life (QOL). This study was performed with aim to investigate the QOL and the related factors in Iranian women diagnosed with breast cancer in 2014-2015. Methods: This cross-sectional study was performed on 94 women with breast cancer who were selected by convenience sampling in Mashhad, Iran from 2014-2015. The data were collected through Demographic and Clinical Questionnaire and EORTC QLQ-C30.V3 Standard Questionnaire. Data was analyzed by SPSS software (version 18) and also descriptive statistics and linear regression analysis. Pconsidered statistically significant. Results: The mean of total score for the quality of life was 71.45± 22.28. In the area of the symptoms of disease, the highest score belonged to insomnia (22.73± 14.89) and fatigue (19.81± 14.42). In the functional area, physical and emotional scales accounted for the highest (91.35±9.67) and lowest (78.55±2.84) scores, respectively. The results of multiple regression analysis showed that the variables of age, social status, radiotherapy, and hormone therapy are effective factors in the QOL. Conclusion: Breast cancer can affect the women’s QOL. Therefore, efforts to promote the QOL in breast cancer patients is considered as one of the most important topics in women’s health care. This requires more attention to identify various aspects of life and find effective ways to promote and improve the QOL in these patients.- انتشار مقاله: 04-11-1395
- نویسندگان: Fatemeh Homaee Shandiz,Fatemeh Zahra Karimi,Zahra Khosravi Anbaran,Mahbubeh Abdollahi,Nafiseh Rahimi,Mina Ghasemi
- مشاهده