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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: molecular subtypes,Breast carcinoma,histological grade,lymph node metastases
- چکیده:
- چکیده انگلیسی: Objective: Breast carcinoma is a heterogeneous disease which is rich in diversity. Molecular subtypes of breast
cancer, histological grade and lymph node metastases are strong prognostic and predictive factors. In Indonesia,
only a limited number of studies have investigated the correlation between molecular subtypes with histological
grade and lymph node metastases. Methods: We analyzed 247 invasive breast carcinoma cases from the Anatomic
Pathology Installation of Dr. Sardjito General Hospital Yogyakarta between 2012-2015. The slides were stained for
estrogen receptors (ER), progesterone receptors (PR), HER2, Ki-67 and CK5/6 for classification into breast cancer
subtypes (BCS). Histological grade using the Nottingham system and lymph node status were obtained from anatomic
pathology records. The association between histological grade and lymph node status with BCS was examined with
Chi-square tests. Results: The immunohistochemical features of 247 cases of women with invasive breast carcinoma
were examined. There were 102 (41.3%) patients with Luminal A, 34 (13.8%) patients with Luminal B, 48 (19.4%)
patients with HER2-positive, and 63 (25.5%) patients with triple negative breast cancer (TNBC). There were 148
(59.9%) patients with negative lymph node status and 99 (40.1%) with positive status. Among 63 TNBC cases, 37
(58.7%) patients were positive for CK5/6 staining (basal-like). Statistically, there were significant differences between
histological grade and subtypes (p=0.013). However, no significant differences were found for lymph node metastases
(p=0.540). Conclusion: Among subtypes, Luminal A has the highest frequency, followed by TNBC, HER2-positive
and Luminal B. Histological grade was associated with molecular subtypes of breast carcinoma in Yogyakarta. Grade
I was associated with Luminal A, while Grade III was associated with Luminal B, HER2 and TNBC subtypes.- انتشار مقاله: 18-06-1396
- نویسندگان: Yunita Setyawati,Yeni Rahmawati,Irianiwati Widodo,Ahmad Ghozali,Dewajani Purnomosari
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: age,molecular subtypes,Breast carcinoma,tumor size
- چکیده:
- چکیده انگلیسی:
Objective: Breast carcinoma (BC) is a heterogeneous disease that exhibits variation in biological behaviour, prognosis and response to therapy. Molecular classification is generally into Luminal A, Luminal B, HER2+ and triple negative/basal-like, depending on receptor characteristics. Clinical factors that determined the BC prognosis are age and tumor size. Since information on molecular subtypes of Indonesian BCs is limited, the present study was conducted, with attention to subtypes in relation to age and tumor size. Methods: A retrospective cross-sectional study of 247 paraffin-embedded samples of invasive BC from Dr. Sardjito General Hospital Yogyakarta in the year 2012- 2015 was performed. Immunohistochemical staining using anti- ER, PR, HER2, Ki-67 and CK 5/6 antibodies was applied to classify molecular subtypes. Associations with age and tumor size were analyzed using the Chi Square Test. Results: The Luminal A was the most common subtype of Indonesian BC (41.3%), followed by triple negative (25.5%), HER2 (19.4%) and luminal B (13.8%). Among the triple negative lesions, the basal-like subtype was more frequent than the non basal-like (58.8 % vs 41.2%). Luminal B accounted for the highest percentage of younger age cases (< 40 years old) while HER2+ was most common in older age (> 50 years old) patients. Triple negative/basal-like were commonly large in size. Age (p = 0.080) and tumor size (p = 0.462) were not significantly associated with molecular subtypes of BC. Conclusion: The most common molecular subtype of Indonesian BC is luminal A, followed by triple-negative, HER2+ and luminal B. The majority of triple-negative lesions are basal-like. There are no association between age and tumor size with molecular subtypes of Indonesian BCs.- انتشار مقاله: 18-06-1396
- نویسندگان: Yeni Rahmawati,Yunita Setyawati,Irianiwati Widodo,Ahmad Ghozali,Dewajani Purnomosari
- مشاهده