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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Helicobacter pylori,CYP2C19 genotype,antibiotic resistant strain
- چکیده:
- چکیده انگلیسی: Background: H. pylori is a class I carcinogen and major cause of gastric cancer. Few previous studies reported
relationship between H. pylori infection, CYP2C19 genotype and functional dyspepsia (FD) subtype. The aim of this
study was to determine relationship between CYP2C19 genotype and FD subtype patients(host factor) with antibiotic
resistant strains of H. pylori infection and CagA genotype(bacterial factor). Methods: FD patients who were investigated
with gastroscopy at Thammasat University Hospital, Thailand during March 2017-November 2017 were enrolled. Two
antral gastric biopsies were obtained for rapid urease test, E-test and cultures. CagA genotypes (CagA1a and CagA2a)
were determined by PCR and CYP2C19 genotype was determined by PCR-RFLP. FD patients were categorized as
epigastric pain syndrome(EPS) and postprandial distress syndrome (PDS). Results: 93 FD patients with H. pylori
infection were enrolled (37 male, 56 female, mean age 54.5 years). There were 33 patients with EPS and 60 patients
with PDS. CYP2C19 genotype revealed 55.9% rapid metabolizer (RM), 40.9% intermediate metabolizer (IM) and
3.2% poor metabolizer (PM) genotypes. Antibiotics susceptibility tests demonstrated 62.8% resistant to metronidazole,
12.9% resistant to clarithromycin and 27.1% resistant to fluoroquinolone. CagA 1a and CagA 2a were demonstrated
in 6 patients(11.5%) and 46 patients(88.5%). CagA2a genotype was more prevalent in PDS than EPS patients
(94.3%vs.76.5%; P =0.08) without significance. In intermediate metabolizer (IM), CagA2a genotype was significant
higher in PDS than EPS(100% vs.25%; P=0.004). Conclusions: PDS, CYP2C19 RM genotype and CagA 2a gene of
H. pylori infection were the predominant type of FD in Thailand. Metronidazole remain the most common antibiotic
resistant strain of H. pylori infection in FD patients. PDS (host factor) was significantly related to CagA2a genotype
(bacterial factors) only in patients with intermediate metabolizer. Appropriate dose of proton pump inhibitor (PPI) and
correct regimens for H. pylori eradication in FD patients should be consider to improve clinical outcomes.- انتشار مقاله: 21-09-1397
- نویسندگان: Jeerayuth Auttajaroon,Peranart Chotivitayatarakorn,Yoshio Yamaoka,Ratha-Korn Vilaichone
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Helicobacter pylori,Gastritis,Gastric cancer,peptic ulcer disease,Southeast Asia
- چکیده:
- چکیده انگلیسی: Background: Helicobacter pylori (H. pylori) infection is currently considered as an infectious disease irrespective of
symptoms and stage of disease. This study aimed to survey the impact of H. pylori infection and the current management
approaches in Southeast Asian countries. Materials and methods: This is a survey among 26 experts from 9 Southeast
Asian countries (Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand and Vietnam),
who attended a meeting to develop the ASEAN consensus on H. pylori management in November 2015. Results: The
prevalence of H. pylori varied significantly from 20% to 69% among countries, highest in Myanmar and lowest in
Malaysia. The rate of H. pylori infection in patients with gastritis, peptic ulcer disease and gastric cancer (GC) also
varied significantly, not only among countries but also among regions within the same country. The most common
method for H. pylori diagnosis before treatment was rapid urease test, followed by urea breath test. In multi-ethnic
countries, some ethnic groups including Chinese, Batak and Minahasanese were considered as having higher risk of
GC. There have been no national screening programs for GC in all countries, and a majority of patients with GC were
diagnosed in advanced stages with very poor 5-year survival. Conclusions: The prevalence of H. pylori infection and
its infection rates in related gastrointestinal diseases were significantly different among Southeast Asian countries. The
prognosis of patients with GC in the region was very poor. The result of this survey is a platform for future international
and regional research collaboration.- انتشار مقاله: 08-03-1397
- نویسندگان: Duc Trong Quach,Ratha-korn Vilaichone,Khien Van Vu,Yoshio Yamaoka,Kentaro Sugano,Varocha Mahachai
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Antibiotic resistant,Helicobacter pylori,ASEAN
- چکیده:
- چکیده انگلیسی: Objective: Antibiotic resistance has significantly impact on eradication rates for H. pylori infection and remains
important cause of treatment failure worldwide including ASEAN countries. The aim of this study was to survey
the prevalence and antibiotic resistant pattern of H. pylori infection in ASEAN. Methods: This study was a survey among
26 experts from 9 ASEAN countries including Thailand, Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines,
Singapore and Vietnam whom attended a meeting to develop the ASEAN consensus on H. pylori management in Bangkok
in November 2015. A questionnaire was sent to each member of the consensus meeting. The detail of the questionnaire
included information about prevalence of H. pylori infection, facilities to perform H. pylori culture, molecular testing
for antibiotic resistance and antibiotic resistance rate in their countries. Results: H. pylori infection remain common
in ASEAN ranging from 20% in Malaysia, 21-54% in Thailand and 69% in Myanmar. Most of ASEAN countries
can perform H. pylori cultures and antibiotic susceptibility tests except Laos and Cambodia. In ASEAN countries,
metronidazole resistant H pylori is quite common whereas amoxicillin resistance remain rare. Clarithromycin resistance
results in a significant decrease in H. pylori eradication rate with clarithromycin-containing regimens. The prevalence of
clarithromycin resistance varies in ASEAN countries being high in Vietnam (30%) and Cambodia (43%), moderate to high
in Singapore (17%) and low in Malaysia (6.8%), Philippine (2%) and Myanmar (0%). In Thailand, clarithromycin
resistance tends to higher in large cities (14%) than in rural areas (~3.7%). Conclusion: ASEAN countries should
develop a standard protocol for regular susceptibility testing of H. pylori so that clinicians would be better able to
choose reliably effective empiric therapies. The wide range of antibiotic resistance in ASEAN countries suggests that
the preferred first line regimen should be depend on the local antibiotic resistance other than single recommendation.- انتشار مقاله: 30-11-1396
- نویسندگان: Ratha-Korn Vilaichone,Duc Trong Quach,Yoshio Yamaoka,Kentaro Sugano,Varocha Mahachai
- مشاهده