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- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,ESR1,Saudi Arabia,genetic variant
- چکیده:
- چکیده انگلیسی: Objective: The present study aimed to determine the role of ESR1 gene rs2234693 T/C polymorphism (PvuII) in the susceptibility to breast cancer and to assess the association of this polymorphism within presence or absence of estrogen, progesterone receptors, human epidermal growth factor receptor 2 (HER2) and with premenopausal and postmenopausal age in Saudi women. Methods: The study was a retrospective case-control study. In this study, 137 breast cancer and 98 normal breast paraffin embedded tissues were included. DNA was extracted and ESR1 gene rs2234693 T/C polymorphism was genotyped by PCR-RFLP. Genetic association tests were performed. Results: The results showed no significant difference in distribution of rs2234693 T/C alleles and genotypes frequencies. Odd ratios (95% CI) were 1.15 (0.8-1.66) and 1.06 (0.5-1.98) and p values were 0.51 and 0.87, respectively. The genotypes and alleles frequencies within different hormonal receptors groups and ages of menopause showed no signification association (odd ratios were less or close to 1 and p values > 0.05). Conclusion: ESR1 gene rs2234693 T/C polymorphism was not associated with susceptibility to breast cancer and different menopausal, hormone receptors, and HER2 status in breast cancer patients. Further analysis using larger sample size will be needed to assess the association of different polymorphisms within the gene and risk of breast cancer.
- انتشار مقاله: 20-03-1399
- نویسندگان: Razan Jamaan Al-Amri,Mohammad Kdaimes H Alotibi,Rawya Ibrahim AL-Raddadi,Weam Talal Yehya Shebli,Emad Ibrahim Yagoub Fallatah,Ahmed Safar Alhujaily,Hiba Salaheldin Mohamed
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: risk factors,Meta-Analysis,Nigeria,cervical cancer,human papillomavirus
- چکیده:
- چکیده انگلیسی: Background: Infection with an oncogenic type of human papillomavirus is a prerequisite for the development of precancerous cervical lesions and its subsequent progression to cervical cancer. With an alarming increase in the detection of other suspicious papillomavirus genotypes in both healthy and women with cervical lesions, there is a need for comprehensive data on cervical papillomavirus infection to address cervical cancer and other associated disease burden, especially in Sub-Sarahan Africa, where the bulk of the problem exists. The present study was conducted to develop comprehensive data on the prevalence and circulating genotypes of human papillomavirus in various risk categories in Nigeria. Methods: A systematic review and meta-analysis of peer-reviewed publications on cervical papillomavirus infection were performed. Relevant data were extracted from eligible studies published in PubMed, Web of Science, Embase, Scopus, and Google Scholar, from inception to July 31, 2019. The random-effect model was used to estimate the pooled prevalence. We identified 327 potential studies and pooled data from 18, involving 5697 women aged 15-86 years. Results: The overall pooled prevalence of cervical papillomavirus infection was 42% (95%CI: 30-54%) in the general population and 37% (95%CI: 25-50%) among women living with HIV/AIDs, with the predominance of genotypes 16, 18, 31, 35, 52, 58 and 45. The highest prevalence was observed in teenagers and young adults and the second peak in women 50 years and above. Conclusion: The prevalence of cervical human papillomavirus infection is cumulatively high in Nigeria and HIV is a strong co-factor. We, therefore, strongly recommend the co-screening of human papillomavirus and cervical cancer and integration of the intervention strategy into the existing HIV-care guideline in Nigeria.
- انتشار مقاله: 25-01-1399
- نویسندگان: Auwal Idris Kabuga,Ahmad Nejati,Amanuel Godana Arero,Somayeh Jalilvand,Talat Mokhtari-Azad,Shirin Shahbazi Sighaldeh,Umma Hassan Wali,Shohreh Shahmahmoodi,Mohamed E El Zowalaty
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Opium,Iran,Risk Factor,Case-control,head & neck neoplasms
- چکیده:
- چکیده انگلیسی: Background: Head and Neck (H and N) cancers include malignant tumors of the nasal cavity, pharynx, paranasal sinuses, oral cavity, larynx and salivary glands. Opium use might be related to these cancers. The aim of this study was to investigate the relation between Opium and its Derivatives (O and D) use and the incidence of H and N cancers. Methods: In this case-control study conducted in Kerman, 140 patients with H and N cancers and 280 healthy controls (matched for age, gender, and place of residence) were included. Information about their use of O and D, cigarette smoking, alcohol and diet were collected using a structured questionnaire. Conditional logistic regression was used to investigate the relation between variables. Results: The use of opioids was associated with an increased risk of HandN cancers (Adjusted OR: 8.13; CI: 4.08-16.2). A significant dose-response relation between O and D use was observed, with high use Adjusted OR=8.91; 95% CI: 4.03-19.65 and low use Adjusted OR=6.52; 95% CI: 3.18- 13.36. This dose-response association was stronger in patients with laryngeal cancer and opioids use, with high use Adjusted OR = 11.17; 95% CI=4.48-28.09 and low use Adjusted OR = 9.46; 95% CI= 3.97- 22.52. Conclusion: The results show that opium use can be considered as an important risk factor for H and N cancers. Also in Iran, opium seems to play a more important role than cigarette smoking.
- انتشار مقاله: 13-09-1398
- نویسندگان: Hosniyeh Alizadeh,Ahmad Naghibzadeh Tahami,Narges Khanjani,Vahid Yazdi-Feyzabadi,Hadi Eslami,Vahidreza Borhaninejad,Mohammad Hasan Larizadeh,Ahmad Enhesari,Reza Abbasi-Rayeni,Vahid Moazed,Aliasghar Arabi Mianroodi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: children,Parents,risk factors,Acute Lymphoblastic Leukemia
- چکیده:
- چکیده انگلیسی: Background: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Different
environmental factors might be effective in the occurrence of this malignancy during childhood. The aim of this study
was to find environmental risk factors in childhood ALL in Hamadan, Iran. Methods: This case-control study was
done in 2015-2018 on 125 children younger than 15 years of age suffering from ALL. Patients were matched with
130 controls with respect to age, gender, and residence location. The identification of risk factors for ALL was sought
based on the comparison of studied variables between case and control individuals. Results: A statistically significant
increased risk for ALL was found with regard to type of delivery (OR: 0.43, 95% CI: 0.20 - 0.92, p˂0.02), childcare
(OR: 4.58, 95% CI: 0.95 - 22.20, p˂0.04), birth weight (OR: 1.44, 95% CI: 1.53 - 2.21, p˂0.006), father’s education
level (OR: 2.67, 95% CI: 1.10 - 6.45, p˂0.02), and father’s job (OR: 0.2 95% CI: 0.08 - 0.51, p˂0.001). Also observed
were increased odds for ALL regarding male gender, mother’s high education level, mother’s freelance job, and medium
or high family income. No association with ALL incidence was observed for age, gender, breastfeeding, mother’s age
at pregnancy, malignancy in first- or second-degree relatives, or mother’s use of hair dye during pregnancy (p> 0.05).
Conclusion: This study showed that father’s education level, father’s job, delivery type, birth weight, and childcare
can play a role in the incidence of childhood ALL.- انتشار مقاله: 07-03-1398
- نویسندگان: Hassan Rafieemehr,Fereshteh Calhor,Hossein Esfahani,Somayeh Ghorbani Gholiabad
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Acute Lymphoblastic Leukemia,Protein expression,Resveratrol,Prednisolone,MDR1 gene
- چکیده:
- چکیده انگلیسی: Objective: Chemotherapy is the most widely recognized technique to regard leukemia and also different sorts of
human tumors. In any case, tranquilize protection has stayed as the primary test against the adequacy of medications.
Besides, having different unfriendly impacts, chemotherapy drugs are getting to be traded by characteristic modalities for
growth treatment. In such manner, natural segments, for example, resveratrol and prednisolone have been recognized to
sharpen the leukemic cells to modified cell demise through an arrangement of complex procedures. In this investigation,
we have analyzed effect of 15, 50 and 100μM of resveratrol and 700μM of prednisolone on the human multidrug
protection quality 1 (MDR1) as a notable marker for cell sedate protection. We assessed the impact of resveratrol and
prednisolone on MDR1 protein expression in the CCRF-CEM cell line as an agent for intense lymphoblastic leukemia.
The investigation was planned to clear up whether. Materials and methods: CCRF-CEM cells linage get under
drug treatment with use of resveratrol and prednisolone. Western blot use at 24 and 48 hours with different doses of
resveratrol and prednisolone to analysis of MDR1 expression changes. Results: Effect of 15, 50, and 100 micro molar
of resveratrol and 700 micro molars of prednisolone on CCRF-CEM cells led to the MDR1 decrease. Western blot use
for evaluation of MDR1 protein expression changes. Conclusion: In the present study, we observed that resveratrol
and prednisolone, with a dose-dependent effect, can reduce the expression of the MDR1 protein. This reduction of
expression demonstrates that resveratrol and prednisolone can overcome to drug resistance created by MDR1.- انتشار مقاله: 14-07-1397
- نویسندگان: Mehdi Talebi,Sina Bahar Aghdam,Ako Azimi,Hamed Mohammadi,Somayyeh Karimi Yonjali,Maryam Asariha,Milad Zadi Heydarabad
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Intronic Mutation,Haplotype
- چکیده:
- چکیده انگلیسی: Background: Breast cancer is the most common cancer diagnosed among women, Tumor suppressor genes such
as BRCA1 involved in cell cycle control and repairing of DNA damage. BRCA1 is a risk factor gene that alteration
in its protein cause in susceptibility to breast or ovarian cancer. Short tandem repeat (STR) polymorphism is linked to
some disease. Objective: The aim of this study was screening a new mutation in patients with familial breast cancer.
Materials and Methods: In this study, 200 women with breast cancer were participated. Among the patients, 40 women
suffer from familial breast cancer. After DNA extraction from peripheral blood samples, Exons 16 to 23 of BRCA1 gene
directly analyzed in SSCP gel electrophoresis followed by direct sequencing. Results: After direct sequencing, a new
mutation was detected in intron 17 of BRCA1 gene. Three patients of one family have a germ line intronic mutation in
the BRCA1 gene (IVS17-27delA). Also, this mutation in this family is linked to a haplotype of intragenic short tandem
repeat (STR) in the BRCA1 gene. Conclusion: By Screening of gene mutations can be found association of mutation
and incidence of disease. Also, studying the mutation in families and finding specific hereditary patterns in that family
can be effective in prognosis of disease in other family members.- انتشار مقاله: 20-06-1397
- نویسندگان: Seyed Mohsen Miresmaeili,Fatemeh Jafari
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Radiotherapy,Meta-Analysis,Nasopharyngeal neoplasms,cetuximab,Nimotuzumab
- چکیده:
- چکیده انگلیسی: Background: It is unclear whether Cetuximab (CTX) or Nimotuzumab (NTZ) concurrent with radiotherapy delivers
equivalent or improved results with fewer toxicities over standard cisplatin (CDDP) concurrent with radiotherapy
in locally advanced nasopharyngeal carcinoma (NPC). Methods: The strategy involved searching the PubMed,
Embase, Cochrane Library, China National Knowledge Internet Web, Wanfang and Chinese Biomedical databases.
Controlled clinical trials that compared concurrent CTX/NTZ with radiotherapy versus CDDP with radiotherapy
in local-regionally advanced NPC were included. Results: In all, 1,239 patients in six clinical trials were included
in the analysis. The hazard ratios (HRs) between the CTX/NTZ and CDDP groups were 1.01 (95% confidence interval
(CI) 0.63-1.64), 1.06 (95% CI 0.50-2.25), 1.04 (95% CI 0.61-1.76), and 1.05 (95% CI 0.73-1.50) for overall survival,
local-regional failure-free survival, distant metastasis failure-free survival, and disease-free survival, respectively.
Significant differences were found in the incidences of grade 3-4 anaemia [Risk ratio (RR) 0.11 95% CI 0.02-0.58], grade
3-4 neutropenia (RR 0.23 95% CI 0.12- 0.44), grade 3-4 thrombocytopenia (RR 0.31 95% CI 0.12- 0.79), and grade
3-4 vomiting (RR 0.04 95% CI 0.00-0.29) in favour of the CTX/NTZ group. However, the patients in the CTX/NTZ
group experienced a higher incidence of grade 3-4 skin rash (RR 6.45 95% CI 3.84-10.84). Conclusions: Regarding
the efficacy and side effects, the combination of CTX / NTZ and radiotherapy may be an alterative treatment regimen
of standard CDDP concurrent with radiotherapy in local-regionally advanced NPC, especially in patients who cannot
tolerate or who refuse chemotherapy.- انتشار مقاله: 15-11-1396
- نویسندگان: Zhong Guo Liang,Guo Xiang Lin,Jia Xiang Ye,Ye Li,Ling Li,Song Qu,Xia Liang,Xiao Dong Zhu
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Journal of Green Chemistry
- نوع مقاله: Journal Article
- کلمات کلیدی: 1,4-Dihydropyridines Acridines Cu(II)-Schiff base/SBA-15 Heterogeneous catalyst
- چکیده:
- چکیده انگلیسی: Herein, we report a fast synthesis of 1,4-dihydropyridines, decahydroacridine-1,8-diones by one-pot multi-component reaction of 1,3-cyclohexanedione or dimidone, arylaldehydes, and ammonium acetate under solvent-less condition using Cu(II)-schiff base-SBA-15 as a reusable heterogeneous catalyst in high yields. These kinds of catalysts are built from mesoporous silica SBA-15 which was covalently anchored with Cu(II) schiff base complex. The shorter reaction times, good yields, simple work-up procedure and environmentally friendly conditions are the main advantages of this method compared to the last one. This method is also the first example of synthesizing acridines by Cu(II)-schiff base-SBA-15 as an efficient catalyst in solvent-free media which can be valuable to be used or investigated for similar systems. The product was identified by its 1H NMR, mass and IR spectra, which were compared to those reported previously.
- انتشار مقاله: 10-04-1396
- نویسندگان: Radineh Motamedi,Ghasem Rezanejade Bardajee,Somayeh Makenali Rad
- مشاهده
- جایگاه : پژوهشی
- مجله: Anthropogenic Pollution Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: Light Pollution Measurement,Sky-glow,Artificial Light,Digital Photography
- چکیده:
- چکیده انگلیسی: Tehran is the most affected town by light pollution in Iran. In this study, the role of the regional topography in the distribution of light pollution in Tehran was evaluated using digital images recording and analyzing the obtained images from Tehran sky-glow by East and South in standard image-processing Software. The scale of Tehran's glowing =dome as measured by 17 mag/arc sec2 or 0.017 cd/m2 by South, and 18.7 (mag/arc sec2) or 0.0035 cd/m2 by East. Considering the approximately equal distance of the two viewpoints from the center of Tehran city, the calculated scale by South is 1.36 times larger than the amount from the East point.
- انتشار مقاله: 14-06-1396
- نویسندگان: Seyed Hamed Mirzakhalil,Sepehr Arbabi Bidgoli
- مشاهده
- جایگاه : پژوهشی
- مجله: Archives of Razi Institute
- نوع مقاله: Journal Article
- کلمات کلیدی: Mesobuthus eupeus,Venom,Chicken,Pathology,Hematology
- چکیده:
- چکیده انگلیسی: This study aimed to evaluate the clinical, histopathological and hematological effects of Mesobuthus eupeus venom on chicken organs. Adult chickens were subcutaneously injected with five doses of M. eupeus venom (0.5, 2, 5, 10 and 20 mg/kg; four chickens per each dose). Symptoms were recorded during the experiment and blood samples were collected for hematological analysis. Moreover, a complete necropsy was performed. After macroscopic examination, tissue samples were obtained from the liver, kidneys, heart, lungs, intestines and brain of the chickens three days after venom administration. In intravenous injection, lethal dose of the venom was determined at 15 mg/kg. The first clinical, pathological and hematological symptoms in envenomated chickens were observed at M. eupeus doses of 2, 5 and 0.5 mg/kg, respectively. Hematological examination revealed a reduction in lymphocyte count following experimental envenomation, which returned to the pre-experiment level in almost all the cases. On the other hand, heterophil count was found to increase during the experimental period. In addition, erythrocyte count and hematocrit level were stable at all the intervals. Pathological examination was indicative of severe pulmonary hemorrhage, pulmonary and cerebral edema, tubular necrosis of the kidneys, hemorrhage in kidneys and heart, hyaline thrombus and congestion of the liver. According to the results of this study, poultry are resistant to the toxic effects of M. eupeus venom.
- انتشار مقاله: 23-10-1394
- نویسندگان: Mohammad Khosravi,Mansour Mayahi,Seyedeh Missagh Jalali,Anahita Rezaie,Ahmad Taghavi Moghadam,Zohreh Hosseini,Seyedeh Kolsum Barzegar,Somayeh Azadmanesh
- مشاهده