در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Diagnosis,treatment,Thyroid cancer,lncRNA,genetic alterations
- چکیده:
- چکیده انگلیسی: Thyroid cancer (TC) is the most common cancer of endocrine system. TC can be subdivided into 4 different entities, papillary, follicular, medullary and anaplastic thyroid cancer. Among them, anaplastic thyroid cancer has the poorest prognosis. Exploring new therapeutic approach may entail favorable prediction as well as increasing overall survival rate of patients. Long non-coding RNAs (lncRNAs), have vast implications in different cancer types. Although they are not transcribed into proteins, they can act as a harness in regulating a plethora of biological functions. They have been implicated in a decisive role in gene expression via modulation of both coding and non-coding RNAs. This article discuss the multi-facet role of lncRNA in thyroid cancer biology.
- انتشار مقاله: 28-10-1397
- نویسندگان: Zeeshan Javed,Faiez Ahmed Shah,Sadegh Rajabi,Qamar Raza,Zaheer Iqbal,Mukhtar Ullah,Touqeer Ahmad,Bahare Salehi,Mehdi Sharifi-Rad,Raffaele Pezzani,Farooq Yaqoob,Haleema Sadia,Marcello Iriti,Javad Sharifi-Rad,William C Cho
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: non-small cell lung cancer,MicroRNAs,miR-9,miR-200c
- چکیده:
- چکیده انگلیسی: MicroRNAs (miRNAs) exert a critical influence on physiological and pathological processes through posttranscriptional
modification of their mRNA targets. They play important roles in tumorigenesis and are considered to
be potential diagnostic and prognostic biomarkers with various cancers. MiR-200c and miR-9 are regulatory elements
that can have dual impacts as oncogenes and/or tumor suppressor genes. MiR-200c regulates two transcription factors,
ZEB1 and ZEB2, while miR-9 is a regulatory factor for the E-cadherin protein which has a critical function in cell-cell
junctions and is inhibited by two transcription factors ZEB1 and ZEB2. In this study, expression levels of miR-200c
and miR-9, ZEB-1, ZEB-2 and E-cadherin were assessed in 30 non-small cell lung cancers (NSCLCs) by real-time
qPCR. MiR-9 was down-regulated significantly in tumor tissues compared to normal adjacent tissues, while there was
no significant change in expression level of miR-200c. On the other hand, ZEB1 demonstrated significant increase
and ZEB2a decrease at the mRNA level. These results indicate roles for miR-9 and ZEB1 in genesis of lung cancer,
although clinico-pathological associations were not evident. Further studies are necessary to assess implications for
treatment of lung cancer.- انتشار مقاله: 01-10-1396
- نویسندگان: Bahareh Nourmohammadi,Elham Tafsiri,Amirabbas Rahimi,Zahra Nourmohammadi,Abolghasem Daneshvar Kakhaki,William Cho,Morteza Karimipoor
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Wnt signaling,therapeutic target,Head and neck squamous cell carcinoma
- چکیده:
- چکیده انگلیسی: Cellular maintenance and development are two fundamental mechanisms regulated by the canonical Wnt signaling
pathway. Wnt/beta-catenin signaling pathway controls a myriad of cellular processes that are essential for normal cell
functioning. Cell cycle progression, differentiation, fate determination, and migration are generally orchestrated by
canonical Wnt signaling. Altered Wnt/beta-catenin signaling has been considered a promoting event for different types
of cancers and the oncogenic potential of Wnt signaling have been discussed in many cancer types, including breast,
colon, pancreatic as well as head and neck. Furthermore, Wnt signaling is critical for the maintenance and stemness
of both the normal as well as cancer stem cells. This review sheds new light on Wnt signaling and explains how it can
regulate normal physiological processes and curtail the development of cancer. It depicts the vital functions of Wnt
signaling in the stem cell growth and differentiation by focusing on current druggable targets that have been ascribed
by recent studies. Thus, Wnt signaling pathway retains a tremendous potential in eradicating head and neck squamous
cell carcinoma.- انتشار مقاله: 29-04-1397
- نویسندگان: Zeeshan Javed,Hafiz Muhammad Farooq,Mukhtar Ullah,Muhammad Zaheer Iqbal,Qamar Raza,Haleema Sadia,Raffaele Pezzani,Bahare Salehi,Javad Sharifi-Rad,William C Cho
- مشاهده