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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Practice,attitudes,cervical cancer screening,Key words: knowledge,HIV-infected women
- چکیده:
- چکیده انگلیسی: Introduction: In recent years, the lives of HIV-infected patients in Thailand have improved significantly due to continuous advances in treatment. However, the rate of cancer related to HIV infection (especially cervical cancer) is likely to increase. Although the World Health Organization (WHO) recommends Papanicolaou testing in all HIV-infected women, few of these patients receive this kind of screening in Thailand. Therefore, we conducted this study to evaluate the knowledge, attitudes, and practices of these patients with regard to cervical cancer screening. Materials and Methods: This cross-sectional study was conducted in HIV-infected women aged 18-65 years from April to November 2019 via a self-administered cervical cancer screening questionnaire, which consisted of four parts: demographic data, knowledge, attitudes, and practices. Results: Three hundred HIV-infected women were recruited. Most of the participants had good attitudes toward screening and practiced adequate screening (75.3% and 71.3%, respectively). However, only 62 participants (20.7%) demonstrated adequate knowledge. The crucial factors that were associated with adequate screening practice were age 40-49 years-old (AOR =3.26, 95%CI=1.02-10.37), CD4 cell count (AOR = 3.41, 95%CI = 1.29-8.99), having been advised about cervical cancer screening (AOR= 6.23, 95%CI 1.84-21.07), and attitude toward screening (AOR= 5.7, 95%CI = 2.23-14.55). The major reasons for not undergoing screening were embarrassment (41.86%), lack of symptoms (41.86%), fear of the results (36.04%), and fear of pain (36.04%). Conclusion: The reasons for inadequate testing were disregard and misconceptions about the procedure. To prevent invasive cervical lesions in HIV-infected women, health care providers should inform these patients about the importance of regular cervical cancer screening.
- انتشار مقاله: 25-01-1399
- نویسندگان: Athiwat Songsiriphan,Lingling Salang,Woraluk Somboonpha,Nuntasiri Eamudomkarn,Wilasinee Nhokaew,Chusri Kuchaisit,Pornnipa Harnlakorn
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: attitude,Knowledge,human papillomavirus,nationwide,social media site
- چکیده:
- چکیده انگلیسی: Objectives: This study was performed first to assess Thai women’s knowledge and attitude toward Human papillomavirus (HPV) infection and vaccination and second to find out factors associated with knowledge in this regard. Methods: The survey announcement was advertised via Facebook from 17 May 2019 to 14 June 2019 to recruit women aged 18-26 years living in Thailand. A score below 5 out of total score of 10 on the survey was considered as a poor level of knowledge. Multivariate analysis was applied to identify factors associated with HPV infection and vaccination knowledge. Results: A total of 1,175 participants were recruited. The participants’ median age was 22 years. Approximately, 46% of the participants had poor level of knowledge regarding HPV infection and vaccination. Factors associated with poor knowledge included low educational level (adjusted OR, 1.35; 95% CI 1.04-1.77), low family income (adjusted OR, 2.14; 95% CI 1.65-2.78), being Christian (adjusted OR, 4.04; 95% CI 1.22-13.40), being engaged in sexual intercourse (adjusted OR, 0.75; 95%CI 0.58-0.97), and being unvaccinated against HPV infection (adjusted OR, 5.74; 95% CI 3.07-10.74). Conclusion: Nearly half of the Thai women who participated in the survey had poor level of knowledge regarding HPV infection and vaccination, indicating a need for more effective health education intervention. Factors associated with knowledge included socioeconomic status and sexual behavior.
- انتشار مقاله: 14-11-1398
- نویسندگان: Naratassapol Likitdee,Chumnan Kietpeerakool,Bandit Chumworathayi,Amornrat Temtanakitpaisan,Apiwat Aue-aungkul,Wilasinee Nhokaew,Nampet Jampathong
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Survival,Prognostic Value,Ovarian Cancer,PD-L1 expression,Immunotherapy
- چکیده:
- چکیده انگلیسی: Objective: To examine the expression of programmed death ligand 1 (PD-L1) in type I and type II epithelial
ovarian cancers (EOC) and its associations with outcomes. Methods: Records of 132 women with EOC were reviewed.
Immunostaining of PD-L1 was performed with formalin-fixed, paraffin-embedded specimens. Expression of PD-L1 was
classified into four categories (0; 1+; 2+; 3+) according to intensity of expression. Expression of PD-L1 ≥2+ was deemed
to be high. Results: Of the 132 women, 75 (56.8%) and 57 (43.2%) women had type I and type II tumors, respectively.
Approximately 70% of cases exhibited high PD-L1 expression. There was no significant difference in the rate of high
PD-L1 expression between the two EOC types (65.3% versus 59.6%). In type I tumors, high PD-L1 expression was
associated with more advanced stages (51.0% versus 34.6%), greater recurrence (46.9% versus 26.9%), and shorter
median progression-free survival (27 months versus 62 months) than low expression. In type II tumors, there were no
apparent differences between high and low expression of PD-L1 in terms of the percentage of advanced-stage tumors
(82.6% versus 79.4%), recurrence (56.5% versus 58.8%), and median progression-free survival (21 months versus
24 months). Conclusion: high PD-L1 expression is associated with worse oncological outcomes in type I EOC. This
finding emphasizes the merit of further studies to confirm this promising result and to determine the potential role of
PD-L1 blockade therapy in type I EOC.- انتشار مقاله: 14-07-1397
- نویسندگان: Wilasinee Nhokaew,Pilaiwan Kleebkaow,Nipon Chaisuriya,Chumnan Kietpeerakool
- مشاهده