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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: MRI,Key words : Glioma,Diffusion magnetic resonance imaging
- چکیده:
- چکیده انگلیسی: Background: To compare diagnostic accuracy between DWI visual scale assessment and ADC value measurement of solid portion of the tumor in grading gliomas. Methods: This retrospective study included 38 patients who had pathologically proven gliomas between January 2013 and August 2018 with 18 low grade and 20 high grade tumors. All patients underwent MRI and biopsy. Two readers reviewed DWI visual scale independently. Disagreement was resolved by consensus. One reviewer measured ADC value of entire solid part of the tumor in single axial slice with greatest dimension of tumor which was chosen by consensus. Two data sets of visual scale and ADC value were analyzed and comparison of diagnostic accuracy in glioma grading was done by using area under the curve (AUC) of receiver operating characteristic curve (ROC). Results: Visual scale and ADC value could be used to distinguish between low and high grade gliomas with a statistically significant difference. (P-value 0.002 and <0.001). Almost all high grade gliomas had visual scale 5. The sensitivity, specificity, PPV NPV and accuracy were 50%, 100%, 100% , 64.3%,73.68% respectively. The cutoff level for the ADC value was determined to be 1119.48 x10-6 mm2/s in differentiation between low and high grade gliomas with the sensitivity, specificity, PPV, NPV, accuracy of 90%, 88.89% , 90%, 88.9% and 89.47% respectively. There was no statistically significant difference(P-value = 0.163). Conclusion: Both Visual scale and ADC value were capable of differentiating between low and high grade gliomas. Although visual scale may not replace ADC measurement, larger scale prospective study is needed for validate this initial result.
- انتشار مقاله: 23-03-1398
- نویسندگان: Warinthorn Phuttharak,Jureerat Thammaroj,Sakda Wara-Asawapati,Kobporn Panpeng
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Background: Thyroid ultrasound(US) is used as the first diagnostic tool to assess the management of disease but
is operator dependent. There have been few reports evaluating interrater variability in US assessment. Therefore, we
evaluated interrater reliability in US assessment of thyroid nodules and estimated its diagnostic accuracy for various
TIRADS systems. Methods: This retrospective study included 24 malignant nodules and 84 benign nodules from
January 2015 to October 2017. Two blinded observers independently reviewed stored US images by using TIRADS. All
analyses followed guidelines proposed by ACR-TR, Siriraj-TR and EU-TR systems. Interrater reliability was calculated
using Cohen’s Kappa statistics. Diagnostic accuracy were also calculated. Results: Interobserver agreement showed
substantial agreement for composition (K=0.616); echogenicity and echogenic foci showed fair agreement (K=0.327
and 0.288, respectively); margin showed slight agreement (K=0.143). Interrater reliability for the final assessment;
moderate agreement for ACR-TIRADS system (K=0.500); fair agreement for EU-TIRADS system (K=0.209) and
slight agreement (K=0.114) for Siriraj-TIRADS system. The diagnostic performance from the two observers; ACRTIRADS
system; sensitivities were 75% and 79.2%, specificities were 58.3% and 56%, positive predictive value (PPV)
were 34% and 33.9% and negative predictive value (NPV) were 89.1% and 90.4%. For the Siriraj-TIRADS system,
sensitivities were 41.7% and 25%, specificities were 84.5% and 89.3%, positive predictive value (PPV) were 43.5%
and 40% and negative predictive value (NPV) were 83.5% and 80.6%. For the EU-TIRADS system, sensitivities were
45.8% and 66.7%, specificities were 79.8% and 72.6%, positive predictive value (PPV) were 39.3% and 41% and
negative predictive value (NPV) were 83.8% and 88.4%. Conclusion: The ACR-TIRADS had highest interobserver
agreement, a trend to have highest sensitivity and negative predictive value for diagnosis of malignant thyroid nodules.
Siriraj-TIRADS had higher specificity and accuracy, but- انتشار مقاله: 17-10-1397
- نویسندگان: Warinthorn Phuttharak,Arunnit Boonrod,Vivian Klungboonkrong,Thanatchaporn Witsawapaisan
- مشاهده