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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Cholangiocarcinoma,Survival,hepatectomy,Liver failure,Bilirubin
- چکیده:
- چکیده انگلیسی: Objective: All types of cholangiocarcinoma (CCA) require a major hepatectomy, which has many post-operative complications. All complications usually present with persistent hyperbilirubinemia; however, studies on the prediction of post-operative hyperbilirubinemia after hepatectomy for patients with CCA are lacking. We evaluated the causes and patterns of persistent hyperbilirubinemia among the patients who underwent hepatectomy for CCA. Methods: We retrospectively reviewed the records of 216 CCA patients who underwent curative-intent hepatic resection between January 2015 and December 2016. We identified five patterns of hyperbilirubinemia for predicting the cause of persistent hyperbilirubinemia and the respective patient outcome. All clinical parameters and outcomes were analyzed for any significant associations. Results: Twenty-eight patients (24%) had post-operative persistent hyperbilirubinemia. Of these, liver failure was the most common cause (42.9%), followed by bile leakage (14.3%), then cholangitis (3.6%). Re-rising of the bilirubin level after post-operative day 3(the ‘V’ pattern), very well predicted liver failure. Moreover, this pattern was associated with poor survival of the patient. Conclusion: The current study provided a picture of persistent hyperbilirubinemia after hepatectomy for CCA. The proportion of post-operative liver failure was 12 percent. The pattern of serum bilirubin level could be used as a predictor of liver failure and long-term outcomes of CCA patients. The ‘V’ pattern was significantly associated with a high rate of liver failure and poor survival.
- انتشار مقاله: 30-04-1399
- نویسندگان: Weerin Sawangkajohn,Vor Luvria,Natwutpong Leeratanakachorn,Theerawee Tipwaratorn,Suapa Theerakul,Apiwat Jarearnrat,Attapol Titapun,Tharatip Srisuk,Ake Pugkhem,Narong Khuntikeo,Vajarabhongsa Bhudhisawasdi,Supot Kamsa-ard
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: risk factors,Cholangiocarcinoma,Thailand,Systematic review
- چکیده:
- چکیده انگلیسی: Background and objective: Cholangiocarcinoma remains a serious public health concern in Thailand. While many
of the risk factors for cholangiocarcinoma in western countries are well-recognized, it remains unclear whether they
are the same in Thailand. We set out to investigate the risk factors for cholangiocarcinoma in Thailand. Methods:
Starting March 4, 2016, we reviewed studies found using pre-specified keywords on SCOPUS, Pro Quest Science
Direct, PubMed, and online public access catalog of Khon Kaen University. Two review authors independently screened
studies for inclusion criteria, extracted data, and assessed the studied Risk of Bias. The Newcastle-Ottawa Scale and the
Joanna Briggs Institute Critical Appraisal Tools were used to assess the quality of included studies. The risk effects of
factors were estimated as a pooled adjusted odds ratio with a 95% confidence interval. The heterogeneity of results was
considered using the I-square, Tau-square and Chi-square statistics. Results: A strong association was found between
cholangiocarcinoma and age, Opisthorchis viverrini infection, eating raw cyprinoid fish, family history of cancer, liquor
consumption, and taking praziquantel. There was only a mild association found between eating nitrite-containing foods,
fresh vegetables, education, smoking behavior, and sex. No association was found between cholangiocarcinoma and
eating fermented fish (Pla-ra), northeastern Thai or Chinese sausage, sticky rice, meat, chewing betel nut, or eating
fruit. There were two protective factors including fresh vegetables consumption and education attainment. Conclusion:
There are unique risk factors of cholangiocarcinoma in Thailand, including age, Opisthorchis- انتشار مقاله: 24-09-1396
- نویسندگان: Siriporn Kamsa-ard,Supot Kamsa-ard,Vor Luvria,Krittika Suwanrungruang,Patravoot Vatanasapt,Surapon Wiangnon
- مشاهده