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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Hepatocellular carcinoma,complete response,predictive factors,selective TACE
- چکیده:
- چکیده انگلیسی: Background: To determine the effectiveness and performance of selective conventional transarterial
chemoembolization (TACE) and analyze the potential predictive factors of sustained complete response (CR) for
patients with hepatocellular carcinoma (HCC). Materials and Methods: Total of 52 patients with HCC (33 males,
19 females; mean age 64.0 ± 9.6 years) who underwent 81 sessions of selective TACE between November 2015 and
March 2017 at Songklanagarind hospital were reviewed. The Kaplan-Meier method was used to describe CR rates at
various time points. Univariate and multivariate logistic regression models were performed to determine the predictive
factors for sustained CR at six months. Results: The CR rates after selective TACE at 1, 4, 6, 9 and 12 months were
87%, 81%, 62%, 40% and 31%, respectively. Univariate and multivariate analyses demonstrated that alpha fetoprotein
level <100ng/ml, a tumor size in summation ≤ 30 mm, ≤ 2 sessions of selective TACE and unilobar involvement had a
significantly higher odds of sustaining complete response at six months (p =0.018, 0.031, 0.032, and 0.044, respectively).
Conclusions: Selective TACE has a good therapeutic results and can sustained complete response in selected HCC
patients. Serum AFP≤ 100 ng/ml, a few sessions of selective TACE, tumor size in summation ≤ 30 mm and unilobar
involvement were favorable predictive factors for sustained complete response of HCC patients.- انتشار مقاله: 25-02-1397
- نویسندگان: Kittipitch Bannangkoon,Keerati Hongsakul,Teeravut Tubtawee,Edward Mc Neil,Hutcha Sriplung,Virasakdi Chongsuwiwatvong
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Screening,Colorectal cancer,Thailand,Willingness to pay,Copayment
- چکیده:
- چکیده انگلیسی: Background: The incidence rate of colorectal cancer in Thailand is increasing. Hence, the nationwide screening
programme with copayment is being considered. There are two proposed screening alternatives: annual fecal
immunochemical test (FIT) and once-in-10-year colonoscopy. A copayment for FIT is 60 Thai baht (THB) per test
(≈ 1.7 USD); a copayment for colonoscopy is 2,300 THB per test (≈ 65.5 USD). Methods: The willingness to pay
(WTP) technique, which is theoretically founded on a cost-benefit analysis, was used to assess an effect of copayment on
the uptake. Subjects were patients aged 50-69 years without cancer or screening experience. WTP for the proposed
tests was elicited. Results: Nearly two thirds of subjects were willing to pay for FIT. Less than half of subjects were
willing to pay for colonoscopy. Among them, median WTP for both tests was greater than the proposed copayments.
In a probit model, knowing CRC patient and presence of companion were associated with non-zero WTP for FIT.
Presence of companion, female, and family history of cancer were associated with non-zero WTP for colonoscopy.
After adjustment for starting price in the linear model, marital status, drinking behavior, and risk attitude were associated
with WTP. None of factors was significant for colonoscopy. Uptake decreased as levels of copayment increased.
At proposed copayments, the uptake rates of 59.8% and 21.6% were estimated for colonoscopy and FIT respectively.
The demand for FIT was price inelastic; the demand for colonoscopy was price elastic. Estimates of optimal copayment
were 62.1 THB for FIT and 460.2 THB for colonoscopy. At the optimal copayment, uptake rates would be 59.8%
for FIT and 42.3% for colonoscopy.Conclusion(s): More subjects were willing to pay for FIT than for colonoscopy
(59.0% versus 46.5%). The estimated uptake rates were 59.8% and 21.6% for colonoscopy and FIT at the proposed
copayments.- انتشار مقاله: 10-12-1396
- نویسندگان: Udomsak Saengow,Stephen Birch,Alan Geater,Virasakdi Chongsuwiwatvong
- مشاهده