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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Applied Biotechnology Reports
- نوع مقاله: Journal Article
- کلمات کلیدی: Inflammation,Inflammatory bowel disease,Dextran sodium sulfate,acetyl-11-keto-β-boswellic Acid
- چکیده:
- چکیده انگلیسی: Introduction: Inflammatory Bowel Disease (IBD) is a term used to denote concurrently the two chronic inflammatory conditions of Gastrointestinal (GI) tract viz: Chron’s Disease (CD) and Ulcerative Colitis (UC). This study has aimed to focus on Acetyl-11-keto-beta-boswellic acid (AKBA) which is an active phytochemical derivate from the gum resin of the Boswellia serrata in order to investigate its anti-inflammatory potential against dextran sodium sulfate-induced colitis in Swiss albino mice.
Materials and Methods: The 3% of Dextran Sodium Sulfate (DSS) polymer in drinking water was fed to different mice groups with distinct timeline for both acute (7days) and chronic colitis induction (3 cycles of 5 days feeding with 15 days gap method). The anti-inflammatory activity of AKBA (50 mg/kg) was evaluated by performing various anti-oxidant assays on tissue homogenate samples (colon, liver, and kidney) and further histological studies.
Result: The oral administration of AKBA (50 mg/kg) had managing effects in IBD mice. Results showed that AKBA lowered the inflammation and soreness compared to the DSS administered mice groups. The histopathology of the intestinal wall was performed and clear morphological changes were observed under light microscopy of both acute and chronic colitis groups of mice. Furthermore, various anti-oxidant assays were performed on tissue sections of chronic colitis mice. Results from histological studies indicated that the chemo-preventive effect of AKBA was attributed to a collection of activities including anti-proliferation, apoptosis induction, and anti-inflammation.
Conclusions: In accordance with the findings, the AKBA active derivative showed anti-inflammatory activity against the DSS induced acute and chronic colitis in mice. However, further clinical studies need to be done to bring AKBA as a potential anti-inflammatory drug candidate for treating IBD.- انتشار مقاله: 07-04-1399
- نویسندگان: Susmita Roy,Sruthi Hari,Antara Banerjee,Rajesh Kannan,Ganesan Jothimani,Vijayashree Raghavan,Surajit Pathak
- مشاهده
- جایگاه : پژوهشی
- مجله: Biofuel Research Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: Box-Behnken,Fast pyrolysis,Bio-oil,Forest biomass,Fractional condensation
- چکیده:
- چکیده انگلیسی: The influence of operating conditions on the yield and quality of bio-oil obtained from black spruce wood mixture was studied using an auger reactor. Fast pyrolysis optimization through response surface analysis was carried out with four variables: pyrolysis temperature, solids residence time, nitrogen flow, and temperature of first stage of condensation. The optimal conditions obtained for bio-oil production were 555°C, 129 s, 6.9 L/min, and 120°C, respectively. The product yields were 38.61 wt.% of biochar, 25.39 wt.% of liquid, and 36.52 wt.% of non-condensable gases. Two liquid products were produced at the exit of the two condensers, following the concept of fractional condensation. The oily phase yield recovered in the first condenser was 10.59 wt.%, with a 16.86 wt.% of moisture content. Physical properties of the oily phase were analyzed and compared with the ASTM standard D7544-12. Qualitative identification of chemical compounds was carried out for the oily phase which helped in pyrolysis optimization for the bio-oil production targeted towards its use as fuel in commercial burners. In addition, the oil produced here is one of the lowest in water and solids content, attributable to the unique feature of auger reactors without the need for additional treatments.
- انتشار مقاله: 23-05-1398
- نویسندگان: Brenda J. Álvarez-Chávez,Stéphane Godbout,Étienne Le Roux,Joahnn H. Palacios,Vijaya Raghavan
- مشاهده