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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: International Journal of Biomedicine and Public Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Diagnosis,Therapeutics,carcinogenesis,Folic acid
- چکیده:
- چکیده انگلیسی: Introduction: Folic acid, also known as folate, is one of the water-soluble B vitamins which its derivatives are involved in many metabolic reactions as cofactor, that are mostly contributed in cell growth. Regarding the role of derived cofactors from this vitamin in reactions such as methylation, production of thymidine and purines; seems that there is a relationship between this vitamin and cancer.
Methods: We searched Medline/Pubmed, Scopus, Embase and Web of Science (2000-2017) using term folic acid, carcinogenesis, diagnose and treatment. Our focused was on the articles published within the past 5 years and type of study in culture media, animal models and clinical trials were in our favor.
Results: Candidate mechanisms in carcinogenesis for folic acid include 1: changes in DNA and RNA methylation 2: Damage to the integrity and stability of DNA 3: disruption in repair system of DNA.
Conclusion: Folic acid in carcinogenesis acts as a double-edged sword. The activity type of folic acid depends on the physiological conditions, dosage of the vitamin, age, individual genotypes, target tissues and stage of the disease in patients. High growth rate of cancer cells leads to increase in cell requests of the vitamin, and on the other hand the cells enhance the number of receptors improving the vitamin absorption. Therefore, increasing number of cell surface receptors, it can be applied for non-invasive diagnosis and target therapy.- انتشار مقاله: 07-11-1396
- نویسندگان: Jalil Rashedi,Maryam Akbarzadeh,Hosein Ajami Khiyav,Sanya Haiaty,Vahid Vahedian,Omid Hasanzadeh,Nazila Fathi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: MCF-7,Cisplatin,silibinin,Paclitaxel,Combination therapy
- چکیده:
- چکیده انگلیسی:
Herbal-derived medicines have introduced as sources of novel drugs due to minimum systemic side effects. Silibinin as a flavonoid compound has showed with effective chemotherapeutic effects on different cancers. Here, we investigated the impact of combination therapy of silibinin, with paclitaxel and cisplatin in inhibition of proliferation and induction of apoptosis in MCF-7 cells. Cell proliferation was assessed by MTT assay and the percentage of apoptotic cells was measured using flowcytometric assay. Understand of molecular mechanism of this combination related to apoptotic pathway were evaluated by Real Time RT-PCR assays. The IC50 values for silibinin, paclitaxel and cisplatin were 160 ± 22.2 μM, 33.7 ± 4.2 nM and 3.2 ± 0.5 μM, respectively. Paclitaxel and cisplatin induced higher percentage of apoptosis in MCF-7 (P < 0.05). Treatment of cell line with combination of silibinin and paclitaxel or cisplatin showed enhanced early apoptosis 56% and 61%, respectively (P < 0.05). Gene expression patterns demonstrated a significant decrease in anti-apoptotic Bcl-2 with increase in pro-apoptotic Bax, P53, BRCA1 and ATM mRNA levels. Taken together combination therapy of breast cancer cells by applying paclitaxel or cisplatin with silibinin synergistically increases the anti-proliferative effect of single agents.- انتشار مقاله: 08-03-1396
- نویسندگان: Hadi Chavoshi,Vahid Vahedian,Somaiyeh Saghaei,Mohammad Bagher Pirouzpanah,Mortaza Raeisi,Nasser Samadi
- مشاهده