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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: VETERINARY RESEARCH FORUM
- نوع مقاله: Journal Article
- کلمات کلیدی: Nicotine,Mice,Malondialdehyde,Sperm,Royal jelly
- چکیده:
- چکیده انگلیسی: This study evaluated the possible protective effect of royal jelly (RJ) on sperm parameters and sperm malondialdehyde (MDA) concentration and in vitro fertilizing potential in nicotine (NIC) exposed male mice. Thrtiy-six male BALB/c mice were randomly divided into six groups (n = 6). Group 1 received normal saline, group 2 received 100 mg kg-1 per day RJ, groups 3 and 4 received NIC at doses of 0.50 and 1.00 mg kg-1 per day, respectively and groups 5 and 6 received NIC at doses of 0.50 and 1.00 mg kg-1 per day, respectively plus RJ. Caudal epididymal sperm characteristics, lipid peroxidation and in vitro fertilizing capacity and embryo development were evaluated after 35 days. The NIC treatment caused a significant decrease in sperm motility and viability and fertilization rate along with poor blastocyst formation and increased sperm DNA damage and MDA levels. Moreover, the incidences of chromatin abnormality in spermatozoa were significantly higher in NIC-exposed mice than those of control. Nevertheless, RJ treatment improved sperm parameters and in vitro fertilization outcome as well as sperm lipid peroxidation level. Data from the current study suggest that RJ has a potential repro-protective action against NIC-induced sperm abnormalities and embryotoxicity in mice.
- انتشار مقاله: 24-05-1397
- نویسندگان: Farnam Azad,Vahid Nejati,Ali Shalizar-Jalali,Gholamreza Najafi,Fatemeh Rahmani
- مشاهده
- جایگاه : پژوهشی
- مجله: VETERINARY RESEARCH FORUM
- نوع مقاله: Journal Article
- کلمات کلیدی: Ethylene glycol,vitrification,Dimethyl sulfoxide,Blastocyst,Morula
- چکیده:
- چکیده انگلیسی: The effect of modified vitrification was assessed on cellular development capability in mouse embryos cultured in vitro. In this study, 466 embryos (from zygote to morula stages) were vitrified then thawed embryos have been incubated for in vitro farther development up to blastocyst stage. Also, vitrification and thawing procedures were the same for all experimental groups. Mouse different embryonic cleavage stages were vitrified in ethylene glycol (EG) plus dimethyl sulfoxide (DMSO) and sucrose (VS-1) and EG plus DMSO (VS-2) and thawed by directly placing the vitrified drop into sucrose solution (TS) at 37 ˚C. High recovery (72–97%) of morphologically normal embryos was evident following vitrification and thawing. Development of the vitrified morulae into blastocysts (92%) was higher (p < 0.05). The amount of zygote and 2-cell stages that achieved to blastocyst stage was very low. With progressing the embryo cleavage to morula stage, the embryos that reached to blastocyst were increased to its maximum number. We concluded that the modified vitrification procedure supported better survival of morula stage compared to other cleavage stages in mouse embryos.
- انتشار مقاله: 08-10-1391
- نویسندگان: Mina Ghorbani,Rajabali Sadrkhanlou,Vahid Nejati,Abbas Ahmadi,Gholamreza Tizroo
- مشاهده
- جایگاه : پژوهشی
- مجله: VETERINARY RESEARCH FORUM
- نوع مقاله: Journal Article
- کلمات کلیدی: Fibroblast,T Cell,Dendritic cell
- چکیده:
- چکیده انگلیسی: Dendritic cells (DCs) induce pathogen-specific T cell responses. We comprehensively studied the effects of addition of maturation stimulus, fibroblasts (fibroblast conditioned medium), PHA activated T cells (T cell conditioned medium), and mixture of fibroblast & PHA activated T cells (FCM-TCCM) conditioned media on maturation of DCs. Monocytes were cultured with GM-CSF and IL-4 for five days. Maturation factors included MCM and TNF-α as control group. FCM and TCCM, or FCM-TCCM supernatant were considered as the treatment group. Tumor antigens were added at day five. Matured DCs were harvested at day seven. Phenotypic and functional analyses were carried out using anti (CD14, CD80, CD86, CD83 and HLA-DR) monoclonal antibodies. Phagocytic activity, mixed lymphocyte reaction (MLR) and cytokine production were also evaluated. At the end of culturing period, significantly fully matured DCs with large amount cytoplasm and copious dendritic projections were found in the presence of MCM, TNF-α with or without FCM, TCCM, FCM as well as TCCM. Flow cytometric analysis revealed that expression of CD14 decreased in particular in treated DCs, at the 5th day and expression of CD80, CD86 and HLA-DR was higher when FCM, TCCM, FCM plus TCCM were added to maturation factor. This study demonstrated that DCs matured with these methods had optimum function in comparison with either factor alone.
- انتشار مقاله: 08-10-1391
- نویسندگان: Masoumeh Asadi,Farah Farokhi,Nowruz Delirezh,Meysam Ganji Bakhsh,Vahid Nejati,Keykavos Golami
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Rehabilitation Sciences and Research
- نوع مقاله: Journal Article
- کلمات کلیدی: self-efficacy,Executive Functions,Social Adjustment,Cognitive Brain Training,Practical Cognitive Strategy Training
- چکیده:
- چکیده انگلیسی: Background: Brain processes are controlled and directed by some brain functions called Executive Functioning. Poor EF affects amelioration of brain functions and related behaviors in social and academic life. In the present research, we investigated the relationship between EF and social functions and tested the brain training effect on EF and social functioning improvement.
Methods: The present study aims to investigate the correlation between poor EF and social self-efficacy and social adjustment and examine the efficacy of cognitive EF training on selected components of social functioning. Through available sampling, 369 healthy high school students aged 16-18 participated in the experiment who were randomly assigned into experimental and control groups; the experimental group consisted of 183 persons (105 girls and 78 boys) and the control group consisted of 186 persons (117 girls and 69 boys). Main EF processes (working memory, shifting, inhibition and problem solving) and social functions (social adjustment and social self-efficacy) were assessed and their correlations were measured. In a randomized controlled trial with pretest, post-test and follow-up assessment, the effects of cognitive brain training was studied on self-efficacy and social adjustment performance of the experimental group. The intervention tool was Practical Cognitive Strategy Training (PCST) which used cognitive awareness, cognitive strategy training and cognitive training to accomplish both goals of EF training in twelve ninety-minute sessions, once a week.
Results: Result showed significant moderate correlation between social and executive functions (p ≤ .001). After twelve weeks of brain training practice, participants showed a significant difference in social adjustment and self-efficacy compared with the control group. The pre-, post- and follow-up tests were time-consuming and might have affected the results.
Conclusion: Social functions correlate with EF performance and cognitive brain training can improve social adjustment and self-efficacy.- انتشار مقاله: 18-02-1398
- نویسندگان: Zahra Husseini,Vahid Nejati,Mojtaba Habibi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Rehabilitation Sciences and Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Attention deficit and hyperactivity disorder,Compensatory rehabilitation,Neuropsychological functions
- چکیده:
- چکیده انگلیسی: Background: The effects of aquatic exercises on strength and balance are still controversial, nevertheless an attempt has been made to investigate the effect of underwater trampoline exercise, in comparison with traditional aquatic exercise, on strength, balance, and quality of life in middle-aged women Methods: A total of 26 middle-aged women participated in this study. The participants were randomly allocated into two groups, i.e. underwater trampoline exercise (age: 44.8±10.3yr, height: 1.62±0.6 m, weight: 76.2±8.6 kg) and traditional aquatic exercise (age: 45.7±8.8yr, height: 1.58±0.5 m, weight: 71.8±8.8 kg), using a matching method. Static balance (by stork test), strength (by dynamometer), and quality of life (by SF 36 questionnaire) data were collected before and after applying an 8-week exercise regime (three sessions per week, each session of 30–45 minutes duration). Finally, the data was analyzed by repeated measures ANOVA using SPSS software (Version 21) (P<0.05). Results: The data analysis showed a significant interaction (P<0.05) in regard to higher mean value of criteria in the underwater trampoline group, however the values of hamstring strength and quality of life between the two groups were not significantly different. Conclusion: The current study showed that underwater trampoline exercises can well affect the balance and strength of the users. The underwater trampoline group showed better progress in terms of the mentioned criteria. Therefore, it can be concluded that the underwater trampoline device can create a unique aquatic environment for enhanced therapeutic treatment and musculoskeletal rehabilitation
- انتشار مقاله: 13-04-1397
- نویسندگان: Mahdis Maghsudloo,Vahid Nejati,Jalil Fathabadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Rehabilitation Sciences and Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Attention-Deficit/Hyperactivity Disorder,Cognitive Rehabilitation,Naming,Reading Abilities,Verbal Fluency
- چکیده:
- چکیده انگلیسی: Background: According to the research literature, there was a relationship between cognitive functions of attention and working memory and linguistic skills. The aim of this research was to investigate the effect of cognitive rehabilitation on the improvement of the linguistic skills in 9-12 years old children with attention-deficit/hyperactivity disorder.Methods: 40 students in grade 4, 5 and 6 of a primary school in Miyane city were assigned equally and randomly to two intervention and control groups. The research design was experimental with pre-test, post-test, follow-up, and control group. The language tests included; Thurston Verbal Fluency task, Token test of receptive language, Boston naming speed test, Assessment of Persian Reading Ability (APRA), verbal working memory subtest of Wechsler Intelligence Scale for Children, and Attention Register task. Parental version of the Swanson, Nolan, and Pelham (SNAP-IV) questionnaire was used to screen ADHD. The intervention method was based on Attentive Rehabilitation of Attention and Memory (ARAM) with emphasis on attention and working memory. Mixed ANOVA statistical test was used to analyze the data.Results: The results showed that the linguistic skills assessed in the research which include naming (F=29.42, P=0.01), verbal fluency (phonological fluency: F=15.68, P=0.01; semantic fluency: F=13.73, P=0.01), reading abilities (alphabet reading 1: F=17.84, P=0.01; alphabet reading 2: F=27.07, P=0.01; word reading: F=19.82, P=0.01; reading ability: F=19.97, P=0.01; voice change: F=13.47, P=0.01; reading comprehension: F=36.85, P=0.01), comprehension (F=6.75, P=0.01), verbal working memory (direct digits: F=7.7, P=0.01; inverse digits: F=14.26, P=0.01) and attention (attention registration 1: F=10.23, P=0.01; attention registration 2: F=4.33, P=0.04) were improved, following the intervention.Conclusion: Computerized Training of working memory and attention can enhance the language skills in children with ADHD. This result confirmed the role of attention and working memory on language skills.
- انتشار مقاله: 21-12-1396
- نویسندگان: Masoomeh Asefi,Vahid Nejati,Masood Sharifi
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Behavioral Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Keywords: Cognitive Functions,Decision-making Competence,Organizational Setting
- چکیده:
- چکیده انگلیسی: AbstractIntroduction: Decision- making as an executive process, consists of a wide range of inputs such as conditioning based on past experiences, sensory and emotional responses, and the anticipation of future goals. The present study aims to investigate the effects of cognitive/executive functions on decision making competence in organizational settings.Method: The sample of this research consisted of 430 managers from 5 industrial companies in Iran who were selected by random sampling method. The instruments which were used in this study were the Cognitive Ability Questionnaire and the Adult Decision Making Competence (A-DMC) tasks. Structural Equation Modeling (SEM) was used through AMOS-22 for data analysis.Results: The results indicated that cognitive/executive functions –planning, cognitive flexibility, inhibitory control, & social cognition- had significant effects on 5 decision making competencies mediating by applying decision rules in the current model.Conclusion: To conclude, from our point of view, different decision-making tasks are separately related to cognitive/executive functions specifically at managerial frameworks. Thus, the current study indicated which cognitive control processes are most operative in the successful performance of managers on different decision tasks. If different executive functions are mainly needed for the successful accomplishment of some decision-making tasks, training these functions in organizations may improve some facets of decision-making performance.
- انتشار مقاله: 25-04-1396
- نویسندگان: Salehe Piryaei,Molouk Khademi Ashkzari,Vahid Nejati,Nasrin Arshadi,Mahmoud Talkhabi
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Mice,Sperm,Oxymetholone,Royal jelly
- چکیده:
- چکیده انگلیسی: Objectives: The aim of the present study was to evaluate protective effect of royal jelly on sperm parameters, testosterone level, and malondialdehyde (MDA) production in mice.
Materials and Methods: Thirty-two adult male NMRI mice weighing 30±2 g were used. All the animals were divided into 4 groups. Control group: received saline 0.1 ml/mouse/day orally for 30 days. Royal Jelly group (RJ): received royal jelly at dose of 100 mg/kg daily for 30 days orally. Oxymetholone group: the received Oxymetholone (OX) at dose of 5 mg/kg daily for 30 days orally. Royal Jelly+Oxymetholone group: received royal jelly at dose of 100 mg/kg/day orally concomitant with OX administration.
Sperm count, sperm motility, viability, maturity, and DNA integrity were analyzed. Furthermore, serum testosterone and MDA concentrations were determined.
Results: In Oxymetholone group, sperm count, motility as well as testosterone concentration reduced significantly (p<0.05), while significant (p<0.05) increases in immature sperm, sperm with DNA damaged, and MDA concentration were announced in Oxymetholone group in comparison with control group and Royal Jelly+Oxymetholone group. RJ caused partially amelioration in all of the above- mentioned parameters in Royal Jelly+Oxymetholone group.
Conclusion: In conclusion, RJ may be used in combination with OX to improve OX-induced oxidative stress and male infertility.- انتشار مقاله: 09-12-1391
- نویسندگان: Ensieh Zahmatkesh,Gholamreza Najafi,Vahid Nejati,Reza Heidari
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: spermatogenesis,Testis,diabetes,Sesame
- چکیده:
- چکیده انگلیسی: Objective(s): Reproductive dysfunction is a consequence of diabetes. Diabetes is associated with changes in testicular tissue. Sesame oil contains large amounts of polyunsaturated fatty acids and lignin with antioxidant activity, vitamin E, and monounsaturated fatty acid (MUFA). The present study investigated the effects of sesame on testis histology and male reproductive parameters in streptozotocin-induced diabetic rats.
Materials and Methods: Thirty mature male Wistar rats were randomly divided into three groups, i.e., control (C), diabetic-control (DC), and sesame-treated diabetic rats (SD). Diabetes was induced by a single dose of streptozotocin (65 mg/kg; i.p). The animals were treated by a single intraperitoneal sesame extract injection (100 mg/kg b.w.) once daily for 6 weeks.
Results: The biochemical analysis revealed that the diabetes resulted in significant (p<0.05) reduction in spermiogenesis, testosterone, LH, and FSH levels. Light microscopic analysis showed remarkable (p<0.05) reduction in STD (seminiferous tubules diameter), SPI (spermatogenesis index) thickness of the epithelium, and significant increase in thickness of the interstitial tissue in the diabetic group compared with the control group. Simultaneous administration of the sesame could fairly up-regulate testosterone, LH, and FSH of the animals in this group. However, some differences were manifested with improved histological features as thickness of the epithelium, seminiferous tubules diameter, and spermatogenesis index.
Conclusion: These data demonstrated that sesame significantly improved diabetes complication in rat testis. This study suggested that sesame might have a protective effect against oxidative stress-induced impaired testicular functions in diabetic rats.
- انتشار مقاله: 10-12-1391
- نویسندگان: Fereshteh Khaneshi,Ozra Nasrolahi,Shahriar Azizi,Vahid Nejati
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Diabetes Mellitus,Streptozotocin,Berberis integerrima,Renal protective
- چکیده:
- چکیده انگلیسی: Objective: Barberry root extract contains various alkaloids that are considered as antioxidants. Beneficial effect of aqueous extract of Berberis integerrima root (AEBIR) was evaluated for renal function in diabetic rats induced by STZ.
Material and Methods: Diabetes was induced by i.p. injection of streptozotocin (65 mg/kg bw) to rats, after 15 h of fasting. Diabetic rats were randomly grouped and treateddaily with AEBIR and glibenclamide by gavage for 42 days. After 6 weeks of study, all the rats were sacrificed and some biochemical parameters of serum and urine were measured and their kidneys tissues were processed for light microscopy.
Results: Streptozotocin induced a significant rise in fasting blood glucose, serum creatinine, blood urea nitrogen, urine glucose, urine protein, urine albumin, and water intake and a significant decrease in body weight, serum protein, urine urea, and urine creatinine. There was a significant restoration of these parameters to near normal after administration of the AEBIR and also by glibenclamide (0.6 mg/kg bw). The activity of the extract at dose of 500 mg/kg in all parameters except blood glucose and urine glucose was more than that of the standard drug, glibenclamide (0.6 mg/kg, p.o.). Histopathological changes of kidney samples were comparable with respective control.
Conclusion: These results suggested that aqueous extract of Berberis Integerrima root improves renal dysfunction in streptozotocin-induced diabetic rats through controlling blood glucose and renal protective effects.- انتشار مقاله: 04-05-1391
- نویسندگان: Hossein Ashraf,Reza Heidari,Vahid Nejati,Minoo Ilkhanipoor
- مشاهده