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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Liver,Echinococcosis,Calcification,biliary fistula
- چکیده:
- چکیده انگلیسی: Thoracobiliary fistula is a rare complication of hydatid cyst disease of the liver especially in calcified form. Given the rarity and high mortality of such fistula, it is not surprising that there is no consensus about surgical treatment of this condition. In the present paper we report two cases of thoracobiliary fistula of complicated calcified hydatid cyst of the liver. A 64-year-old man with cough and biliary sputum and a 66-year-old man with cough and right biliary pleural effusion (pleurobiliary fistula). The patients underwent left hepatectomy with cholecystectomy and T-tube choledochal drainage in one patient and successful decortication of the lung, and cystectomy with excision of calcified pericystectomy of the liver in another patient. Pathologic examinations revealed calcified hydatid cysts of the liver. Because of poor prognosis of thoracobiliary fistula, radical surgical intervention is recommended.
- انتشار مقاله: 11-12-1393
- نویسندگان: Mohsen Sokouti,Vahid Montazeri,Ashraf Fackrju
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Herein, we reported on a case of solid type of pulmonary actinomycosis in a 10-year-old boy. He had productive cough for 40 days. Bronchoscopy was normal. Cmputed tomography revealed a solid large mass in the upper lobe of his left lung with mimicking malignant leisions. He was referred for surgery and underwent left upper lobectomy. Macroscopically, the specimen measured 13×9×5 cm and was creamy to whitish on cut section. Microscopic findings included a large number of inflammatory cells and colonies of actinomyces. Pulmonary actinomycosis should be included in the differential diagnoses of pulmonary mass lesions, especially in the young adults.
- انتشار مقاله: 04-03-1394
- نویسندگان: Vahid Montazeri,M. Sokouti,A. Fakhrju
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Sequencing,Iranian population,BRCA2,SSCP,Mutation detection
- چکیده:
- چکیده انگلیسی: Objective(s): Breast cancer is the most common cancer in women. Every year, one million new cases are reported worldwide, representing 18% of the total number of cancer in women. Hereditary BRCA1 and BRCA2 mutations account for about 60% of inherited breast cancer and are the only known causes of hereditary breast cancer syndrome. The aim of this study was to determine the frequency of BRCA2 (exon2 and exon11) gene mutation in patients with early-onset breast cancer among Iranian Azeri-Turkish women. Materials and Methods: We obtained clinical information, family history and peripheral blood from 110 women under the age of 45 with early-onset breast cancer for scanning germline mutations in the exon2 and 11 of BRCA2 genes which comprises over 50% of the gene. Single-strand conformation polymorphism assay was used in order for screening potential mutations on amplified regions followed by direct sequencing analysis to determine the genotypes. Results: Overall, 11 sequence variants were identified in this study group, including four homozygotes and seven heterozygotes silent substitution of c.3807T to C, p.Val1269Val (rs543304). Conclusion: Mutations in BRCA2 were surprisingly infrequent in the early onset breast cancer patients among Iranian Azeri-Turkish women.
- انتشار مقاله: 29-11-1392
- نویسندگان: Nahid Karimian Fathi,Mahmood Shekari Khaniani,Vahid Montazeri,Sima Mansoori Derakhshan
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Biomarkers,miR-140,miR-196a,Quantitative PCR
- چکیده:
- چکیده انگلیسی: Objective: MiR-140 and miR-196a were known to be correlated with cancer diagnosis and prognosis. The current study aimed at the analysis of miR-140 and miR-196a expression patterns and their clinical significance for breast cancer (BC) patients. Methods: Differentially expressed miR-140 and miR-196a were examined via quantitative PCR in 110 cases of BC and their adjacent non-tumor (ANT) tissues. Results: The results indicated that miR-140 and miR-196a, respectively, notably decreased and increased expression in BC samples in comparison with ANT (p<0.001). Reduced miR-140 expression was also related to Lymph node metastasis (LNM, P= 0.023) and stage (P = 0.009). Additionally, Receiver Operating Characteristics (ROC) analysis illustrated that miR-140 had a significant diagnostic accuracy for stage and LNM of BC patients. We also discovered a strong negative correlation between miR-196a expression with histological grade (P = 0.038), LNM (P = 0.012) and stage (P = 0.001). Conclusion: Overall, exploring the miR-140 and miR-196a profiles not only can statistically different among BC and ANT samples, but it is also expected to become potential BC biomarkers.
- انتشار مقاله: 15-07-1398
- نویسندگان: Arman Shahabi,Behrooz Naghili,Khalil Ansarin,Vahid Montazeri,Nosratollah Zarghami
- مشاهده