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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Prognostic factor,Hepatic resection,CRP/Alb ratio,Intrahepatic cholangiocarcinoma
- چکیده:
- چکیده انگلیسی: Objective: The present study aimed to investigate the impact of preoperative C-reactive protein to albumin (CRP/Alb) ratio on the long-term outcomes of patients with intrahepatic cholangiocarcinoma (ICC). Methods: 82 patients who underwent hepatic resection for mass-forming type of ICC were evaluated. The relationship between preoperative CRP/Alb ratio and survival outcomes was investigated. Results: The optimal cutoff value of CRP/Alb ratio for assessing overall survival (OS) was determined as 0.089. Univariate analysis for recurrence-free survival (RFS) showed that CRP/Alb ratio >0.089, carbohydrate antigen 19-9 (CA 19-9) >37 U/mL, lymph node metastasis, vascular invasion, and multiple tumors were significantly associated with postoperative recurrence. On multivariate analysis, the independent prognostic factors identified were CRP/Alb ratio >0.089 (p < 0.001), lymph node metastasis (p = 0.006), and multiple tumors (p < 0.001). Univariate analysis for OS showed that CRP/Alb ratio >0.089, CA 19-9 >37 U/mL, lymph node metastasis, vascular invasion, multiple tumors, and positive surgical margin were significantly associated with overall death. On multivariate analysis, the independent prognostic factors identified were CRP/Alb ratio >0.089 (p < 0.001), lymph node metastasis (p = 0.01), and multiple tumors (p = 0.005). Conclusion: Preoperative CRP/Alb ratio may predict poor long-term outcomes after hepatic resection in patients with ICC.
- انتشار مقاله: 30-02-1399
- نویسندگان: Tokuji Ito,Hiroji Shinkawa,Shigekazu Takemura,Shogo Tanaka,Takayoshi Nishioka,Toru Miyazaki,Atsushi Ishihara,Shoji Kubo
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Lymph node metastasis,Occupational cholangiocarcinoma,Biliary intraepithelial neoplasia,Intraductal papillary neoplasm of the bile duct,Fluorine-18 fluorodeoxyglucose positron emission tomography
- چکیده:
- چکیده انگلیسی: Objective: The present study aimed to identify the clinical significance of fluorine-18 fluorodeoxyglucose positron
emission tomography (FDG-PET) imaging in patients with occupational cholangiocarcinoma. Methods: This study
included 10 men with occupational cholangiocarcinoma who were former or current workers at a printing company in
Osaka, Japan. Of the 10 patients, 2 had 2 main tumors and 1 had 3 main tumors. Twelve FDG-PET imaging findings
in the 10 patients could be analyzed. We evaluated the relationships between FDG-PET imaging parameters and
clinicopathological findings of occupational cholangiocarcinoma. Results: Abnormal FDG uptake was observed in 8 of
the 14 main tumors, with maximum standardized uptake values ranging from 2.9 to 11.0, and the sensitivity was 57.1%.
Four patients had lymph node metastases, and abnormal marrow uptake was detected in all these patients. Although
precancerous lesions, such as biliary intraepithelial neoplasia (BilIN) and intraductal papillary neoplasm of the bile
duct (IPNB) without any invasion, were not detected, abnormal FDG uptake was demonstrated in 2 of 4 patients with
IPNB having an associated invasive carcinoma.Conclusions: Although FDG-PET may be useful for assessing tumor
progression factors, such as lymph node metastasis, it cannot accurately detect precancerous lesions, such as BilIN
and IPNB without invasive carcinoma.- انتشار مقاله: 10-01-1397
- نویسندگان: Masahiko Kinoshita,Shigekazu Takemura,Shogo Tanaka,Hiroji Shinkawa,Genya Hamano,Tokuji Ito,Masaki Koda,Takanori Aota,Yasuni Nakanuma,Yasunori Sato,Shoji Nakamori,Akira Arimoto,Takatsugu Yamamoto,Hideyoshi Toyokawa,Shoji Kubo
- مشاهده