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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asia Oceania Journal of Nuclear Medicine and Biology
- نوع مقاله: Journal Article
- کلمات کلیدی: Prognosis,FDG-PET/CT,Triple negative breast cancer,Neoadjuvant chemotherapy,Metabolic response
- چکیده:
- چکیده انگلیسی: Objective The mortality of patients with locally advanced triple-negative breast cancer (TNBC) is high, and pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) is associated with improved prognosis. This retrospective study was designed and powered to investigate the ability of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to predict pathological response to NAC and prognosis after NAC.
Methods The data of 32 consecutive women with clinical stage II or III TNBC from January 2006 to December 2013 in our institution who underwent FDG-PET/CT at baseline and after NAC were retrospectively analyzed. The maximum standardized uptake value (SUVmax) in the primary tumor at each examination and the change in SUVmax (ΔSUVmax) between the two scans were measured. Correlations between PET parameters and pathological response, and correlations between PET parameters and disease-free survival (DFS) were examined.
Results At the completion of NAC, surgery showed pCR in 7 patients, while 25 had residual tumor, so-called non-pCR. Median follow-up was 39.0 months. Of the non-pCR patients, 9 relapsed at 3 years. Of all assessed clinical, biological, and PET parameters, N-stage, clinical stage, and ΔSUVmax were predictors of pathological response (p=0.0288, 0.0068, 0.0068; Fischer’s exact test). The cut-off value of ΔSUVmax to differentiate pCR evaluated by the receiver operating characteristic (ROC) curve analysis was 81.3%. Three-year disease-free survival (DFS) was lower in patients with non-pCR than in patients with pCR (p=0.328, log-rank test). The cut-off value of ΔSUVmax to differentiate 3-year DFS evaluated by the ROC analysis was 15.9%. In all cases, 3-year DFS was lower in patients with ΔSUVmax <15.9% than in patients with ΔSUVmax ≥15.9% (p=0.0078, log-rank test). In non-pCR patients, 3-year DFS was lower in patients with ΔSUVmax <15.9% than in patients with ΔSUVmax ≥15.9% (p=0.0238, log-rank test).
Conclusions FDG-PET/CT at baseline and after NAC could predict pathological response to NAC before surgery and the clinical outcome after surgery in locally advanced TNBC patients.- انتشار مقاله: 17-07-1394
- نویسندگان: Sachiko Kiyoto,Yoshifumi Sugawara,Kohei Hosokawa,Rieko Nishimura,Natsumi Yamashita,Shozo Ohsumi,Teruhito Mochizuki
- مشاهده
- جایگاه : پژوهشی
- مجله: Asia Oceania Journal of Nuclear Medicine and Biology
- نوع مقاله: Journal Article
- کلمات کلیدی: Semiconductor detector,Energy resolution,Dual radioisotopes simultaneous SPECT,123I-BMIPP
- چکیده:
- چکیده انگلیسی: Objective(s): The energy resolution of a cadmium-zinc-telluride (CZT) solid-state semiconductor detector is about 5%, and is superior to the resolution of the conventional Anger type detector which is 10%. Also, the window width of the high-energy part and of the low-energy part of a photo peak window can be changed separately. In this study, we used a semiconductor detector and examined the effects of changing energy window widths for 99mTc and 123 I simultaneous SPECT.
Methods: The energy “centerline” for 99mTc was set at 140.5 keV and that for 123I at 159.0 keV. For 99mTc, the “low-energy-window width” was set to values that varied from 3% to 10% of 140.5 keV and the “high-energy-window width” were independently set to values that varied from 3% to 6% of 140.5 keV. For 123I, the “low energy-window-width” varied from 3% to 6% of 159.0 keV and the high-energy-window width from 3% to 10% of 159 keV. In this study we imaged the cardiac phantom, using single or dual radionuclide, changing energy window width, and comparing SPECT counts as well as crosstalk ratio.
Results: The contamination to the 123I window from 99mTc (the crosstalk) was only 1% or less with cutoffs of 4% at lower part and 6% at upper part of 159KeV. On the other hand, the crosstalk from 123I photons into the 99mTc window mostly exceeded 20%. Therefore, in order to suppress the rate of contamination to 20% or less, 99mTc window cutoffs were set at 3% in upper part and 7% at lower part of 140.5 KeV. The semiconductor detector improves separation accuracy of the acquisition inherently at dual radionuclide imaging. In, this phantom study we simulated dual radionuclide simultaneous SPECT by 99mTc-tetrofosmin
and 123 I-BMIPP.
Conclusion: We suggest that dual radionuclide simultaneous SPECT of 99mTc and 123I using a CZT semiconductor detector is possible employing the recommended windows.- انتشار مقاله: 27-01-1393
- نویسندگان: Yasuyuki Takahashi,Masao Miyagawa,Yoshiko Nishiyama,Naoto Kawaguchi,Hayato Ishimura,Teruhito Mochizuki
- مشاهده