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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Recurrence,idiopathic granulomatous mastitis,immunosuppressive therapy,wide local excision,classification system
- چکیده:
- چکیده انگلیسی: Objectives: There is no consensus regarding the surgical or immunosuppressive treatment of idiopathic
granulomatous mastitis (IGM). This study aimed to introduce a clinical classification system for IGM that might facilitate
its treatment and predict recurrence. Methods: We analyzed the management of 68 patients with IGM at (Princess Basma
Teaching Hospital and King Abdulla University Hospital (1994-2016) to find out if distinct patterns of presentation
exist according to the following parameters: presence of a painful or painless breast mass, local inflammation, abscess
formation, communication to the skin, and extra-mammary manifestation. Results: We identified four distinct patterns of
IGM: A: (13.23 %) A hard, painless breast mass. B: (52.94 %) A hard, painful breast mass with gross inflammation.
C: (26.47 %) A breast abscess-like presentation. D: (7. 35 %) A subacute presentation with ulceration, sinus, or fistula
formation. Erythema nodosum might complicate any of these patterns. Wide local excision in pattern A was curative
with zero recurrence rate. The recurrence rates in patterns B and C were 22.20 % and 50.00 %. Patterns B, C, and
D were treated by a combination of surgery and prednisolone. In keeping with this, recent literature is in favor of
a wider use of immunosuppression especially in the presence of pus and extra-mammary findings. Conclusion: IGM
could be classified into 4 distinct patterns according to the presenting signs and symptoms. These patterns correlated
with treatment, recurrence rate, and the gross operative findings. This is the first step toward a classification for IGM.
Multicenter and Meta-analysis studies are essential for a comprehensive prognostic classification. Treatment of IGM
in any institution should be the responsibility of a multidisciplinary team.- انتشار مقاله: 15-08-1397
- نویسندگان: Rami Yaghan,Shadi Hamouri,Nehad M Ayoub,Lamees Yaghan,Tagleb Mazahreh
- مشاهده