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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Cholangiocarcinoma,Survival,hepatectomy,Liver failure,Bilirubin
- چکیده:
- چکیده انگلیسی: Objective: All types of cholangiocarcinoma (CCA) require a major hepatectomy, which has many post-operative complications. All complications usually present with persistent hyperbilirubinemia; however, studies on the prediction of post-operative hyperbilirubinemia after hepatectomy for patients with CCA are lacking. We evaluated the causes and patterns of persistent hyperbilirubinemia among the patients who underwent hepatectomy for CCA. Methods: We retrospectively reviewed the records of 216 CCA patients who underwent curative-intent hepatic resection between January 2015 and December 2016. We identified five patterns of hyperbilirubinemia for predicting the cause of persistent hyperbilirubinemia and the respective patient outcome. All clinical parameters and outcomes were analyzed for any significant associations. Results: Twenty-eight patients (24%) had post-operative persistent hyperbilirubinemia. Of these, liver failure was the most common cause (42.9%), followed by bile leakage (14.3%), then cholangitis (3.6%). Re-rising of the bilirubin level after post-operative day 3(the ‘V’ pattern), very well predicted liver failure. Moreover, this pattern was associated with poor survival of the patient. Conclusion: The current study provided a picture of persistent hyperbilirubinemia after hepatectomy for CCA. The proportion of post-operative liver failure was 12 percent. The pattern of serum bilirubin level could be used as a predictor of liver failure and long-term outcomes of CCA patients. The ‘V’ pattern was significantly associated with a high rate of liver failure and poor survival.
- انتشار مقاله: 30-04-1399
- نویسندگان: Weerin Sawangkajohn,Vor Luvria,Natwutpong Leeratanakachorn,Theerawee Tipwaratorn,Suapa Theerakul,Apiwat Jarearnrat,Attapol Titapun,Tharatip Srisuk,Ake Pugkhem,Narong Khuntikeo,Vajarabhongsa Bhudhisawasdi,Supot Kamsa-ard
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Validation,Colorectal cancer screening literacy,Instrument development,Thai people
- چکیده:
- چکیده انگلیسی: Background: Colorectal cancer is an important public health problem worldwide. Although progress in screening
and treatment has considerably improved the prognosis in the developed world, in developing countries colorectal cancer
mortality rate remains relatively high. Colorectal cancer screening literacy is an important initial step in overcoming this
problem. Development of a validated assessment instrument is therefore important for implementation of appropriate
health education programs to facilitate early detection. Objectives: This study focused on generation and validation of
a colorectal cancer screening literacy scale for Thai people in northeastern Thailand. Methods: This methodological
study was carried out in two phases: (1) literature reviews and semi-structured interviews were used to select items,
then the content and face validity were checked; and (2) a confirmatory factor analysis (CFA) was conducted to test
construct validity and reliability. A self-administered questionnaire was used to collect data from Thai people aged 50-
65 in June 2017. Results: For the total of 400 participants who responded (response rate 100 %), the age ranged from
50 to 65 years old (mean = 57.3, SD = 4.616). The colorectal cancer screening literacy scale was designed to include
6 domains and it was shown to have good internal consistency, and CFA demonstrated the model to fit data adequately
(Chi-squared/degree of freedom = 1.079, p = 0.061, CFI = 1.00, GFI = 0.93, AGFI = 0.91, RMSEA = 0.014 and SRMR
= 0.036). The final version of its, consisting of 57 items across the 6 domains covering key aspects of colorectal cancer
screening literacy, demonstrated good psychometric properties for this population. Conclusions: Use of the colorectal
cancer screening literacy scale in Thai people could lead to improved educational programs for optimizing colorectal
cancer screening.- انتشار مقاله: 01-08-1397
- نویسندگان: Chontira Kawthaisong,Supannee Promthet,Supot Kamsa-Ard,Rujira Duangsong
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: cervical cancer,time trend,population-based cancer registry data
- چکیده:
- چکیده انگلیسی: Background: Cervical cancer is the second most common cancer of women in Thailand. There have been no reports
of incidence and future in Khon Kaen, a province in northeastern Thailand, where the relatively high prevalence gives
evaluation of cervical cancer screening a high priority. Objectives: To determine cervical cancer incidence rates in
Khon Kaen for 1990–2014 and predict future trends until 2029. Methods: Cancer incidence data from the Khon Kaen
population-based cancer registry were analyzed and age-standardized incidence rates (ASR) were estimated. Joinpoint
analysis and age-period-cohort modeling were applied for data from 1990 to 2014 and the Nordpred package was
employed to project trends from 2015 to 2029. Results: Between 1990 and 2014, a total of 3,258 cases were diagnosed
with ICD-O code C53 (invasive cervical cancer). Before 2005, an annual percentage change (APC) varied widely, with
outliers in 1993 and 1999. The APC computed with the Joinpoint software decreased at -2.8% (95% CI;-4.5 to -1.1)
per year on average. After 2005, a rise was noted until 2008, after which a drop became apparent with an APC of
-8.0% (95% CI; -14.5 to -1.1) per year on average. Both period and cohort effects played a role in shaping the decrease
in incidence. The three projection method suggested that incidence rates would continue to decrease in the future.
Conclusions: A decreasing trend in incidence of cervical cancer in Khon Kaen was noted from 1990 to 2014 with a
prediction of continuous decrease until 2029. Maintenance and improvement of the screening program is advised.- انتشار مقاله: 25-07-1397
- نویسندگان: Thitima Saenrueang,Supannee Promthet,Supot Kamsa-Ard,Prasit Pengsaa
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: risk factors,Cholangiocarcinoma,Thailand,Systematic review
- چکیده:
- چکیده انگلیسی: Background and objective: Cholangiocarcinoma remains a serious public health concern in Thailand. While many
of the risk factors for cholangiocarcinoma in western countries are well-recognized, it remains unclear whether they
are the same in Thailand. We set out to investigate the risk factors for cholangiocarcinoma in Thailand. Methods:
Starting March 4, 2016, we reviewed studies found using pre-specified keywords on SCOPUS, Pro Quest Science
Direct, PubMed, and online public access catalog of Khon Kaen University. Two review authors independently screened
studies for inclusion criteria, extracted data, and assessed the studied Risk of Bias. The Newcastle-Ottawa Scale and the
Joanna Briggs Institute Critical Appraisal Tools were used to assess the quality of included studies. The risk effects of
factors were estimated as a pooled adjusted odds ratio with a 95% confidence interval. The heterogeneity of results was
considered using the I-square, Tau-square and Chi-square statistics. Results: A strong association was found between
cholangiocarcinoma and age, Opisthorchis viverrini infection, eating raw cyprinoid fish, family history of cancer, liquor
consumption, and taking praziquantel. There was only a mild association found between eating nitrite-containing foods,
fresh vegetables, education, smoking behavior, and sex. No association was found between cholangiocarcinoma and
eating fermented fish (Pla-ra), northeastern Thai or Chinese sausage, sticky rice, meat, chewing betel nut, or eating
fruit. There were two protective factors including fresh vegetables consumption and education attainment. Conclusion:
There are unique risk factors of cholangiocarcinoma in Thailand, including age, Opisthorchis- انتشار مقاله: 24-09-1396
- نویسندگان: Siriporn Kamsa-ard,Supot Kamsa-ard,Vor Luvria,Krittika Suwanrungruang,Patravoot Vatanasapt,Surapon Wiangnon
- مشاهده