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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Dentistry, Shiraz University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: adenoid cystic carcinoma,p63,matrix metalloproteinase,Mucoepidermoid carcinoma,Maspin
- چکیده:
- چکیده انگلیسی: Statement of the Problem: The tumor suppressor role of myoepithelial cells and related mechanisms in breast tumors are well understood. However, the role of these cells in salivary glands tumors is debatable.
Purpose: The present study was designed to determine the expression of p63, Maspin and Matrix metalloproteinase 2 (MMP-2) in mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ADCC) of salivary glands due to various cellular differentiation and structure. The association between the expression of these markers and clinicopathologic features and myoepithelial differentiation were also evaluated.
Materials and Method: P63, Maspin and MMP-2 expression were immunohistochemically studied in 67 cases including35 cases of MEC and 32 cases of ADCC. The smooth muscle actin (SMA) staining was also applied to confirm the presence of myoepithelial differentiation. Data was analyzed using Chi-square test, Mann-Whitney U test and t-test.
Results: The expression of p63 (p = 0.009) and Maspin (p = 0.012) significantly differed between the study groups.P63 positive cells in MEC were negative for SMA staining in contrast to ADCC. Furthermore, the expression of P63 (p = 0.045) and Maspin (p = 0.019) significantly and inversely correlated with histologic grade in ADCC. Likewise, positive significant correlation was detected between histologic grade and expression of P63 (p = 0.018) and MMP-2 (p = 0.003) in MEC samples.
Conclusion: Ourfindings showed thatMEC is devoid of myoepithelial cells. The difference in expression of P63 and Maspin in ADCC and MEC highlighted the role and presence of myoepithelial cells in ADCC. Indeed, the high expression of P63 and Maspin in well differentiated ADCCs suggests the tumor suppressor effect of myoepithelial cells. Considering the association between the evaluated markers and histological grade, p63 in both tumors, Maspin in ADCC and MMP-2 in MEC may be efficient predictors of clinical behavior.- انتشار مقاله: 17-09-1397
- نویسندگان: Nasim Taghavi,Farzad Yazdani,Alireza Akbarzadeh Baghban,Soudabeh Sargolzaei,Parisa Kardouni Khozestani
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Dental Materials and Techniques
- نوع مقاله: Journal Article
- کلمات کلیدی: benign,Cyst,odontogenic tumor,Maxilla,adenomatoid odontogenic tumor
- چکیده:
- چکیده انگلیسی: Adenomatoid odontogenic tumor is a non-aggressive slow growing epithelial odontogenic tumor with
varied clinical and microscopic features. This
neoplasm rarely appears as a completely cystic lesion histopathologically; therefore, oral pathologists should be aware of the various histopathologic types of this lesion. The main objective of this case report is to present a rare challenging case of maxillary extrafollicular cystic adenomatoid odontogenic tumor affecting a 28-year-old male.
- انتشار مقاله: 25-11-1396
- نویسندگان: Soudabeh Sargolzaei,Saede Atarbashi-Moghadam,Farzad Aghdashi,Sara Mansouri Nejad
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Recurrence,Odontogenic tumors,Calcifying Odontogenic Cyst
- چکیده:
- چکیده انگلیسی: Peripheral calcifying cystic odontogenic tumor (PCCOT) is a rare odontogenic lesion, which represents about 1% of jaw cysts. Here we report clinicopathologic, radiographic and CT scan images of a new case of recurrent large PCCOT located in mandibular gingiva in a 77-year-old male with history of a nodular mass in the same area, which had been completely excised 3 years ago. In reviewing the literature, we found 55 previous reported cases with a mean age of 48.8 yr at the time of diagnosis. A majority of cases appear as a circumscribed nodule less than 1.5 cm in greatest diameter, without bony involvement. No case larger than 4cm in diameter has been reported. Only one case of recurrent PCCOT was seen in reported cases.
- انتشار مقاله: 06-07-1393
- نویسندگان: Nasim Taghavi,Abbas Khodayari,Soudabeh Sargolzaei,Fatemeh Mashhadiabbas,Mohammad Moshref,Ali Lotfi,Leili Mehrdad
- مشاهده