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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Human, Health and Halal Metrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Vegetable,Parasite,Food-borne diseases,Nematode
- چکیده:
- چکیده انگلیسی: Background and objective: Parasitic infections damage human health in different ways especially by gastrointestinal disorders. Several investigations have been done on determination of parasites in vegetables in the world. The aim of this study was to assess the rate of parasitic contamination in edible vegetables available in Yazd city (center of Iran) and suggestion of appropriate methods for prevention and control of the contamination.
Materials and methods: Four hundred samples of washed and unwashed vegetables were investigated by sedimentation and centrifugation method. The method was included to washing the vegetables by water and detergent and then rinsing several times. The sediments were centrifuged and finally stained with Lugol's iodine solution. Vegetables in the study were included to leek, parsley, coriander, dill, radishes, scallion, garden cress, basil, mint, and fenugreek.
Results and conclusion: Sixty fine out of 200 unwashed vegetables (32.5%) and three out of 200 washed vegetable (1.5%) were infected by parasites. The most contamination in the unwashed vegetables were related to terrestrial nematode, inhuman parasite eggs, and parasitic worm eggs, while their contamination dropped significantly in the washed vegetables. Among the all samples, leek and scallion were the most contaminated and radish had the least contamination. The highest level of contamination was observed in summer and the least level of contamination was observed in winter. In conclusion, parasitic contamination of the vegetables in Yazd was at moderate level. However, it is possible to prevent parasitic infection in humans by proper training of people in preparation and disinfection of vegetables.- انتشار مقاله: 25-04-1399
- نویسندگان: Somayeh Mousavi Nodushan,Mahin Ghaforzadeh,Roqieh Sadat Razavi Mahmoodabadi,Naeimeh Akramzadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Trends in Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Hepatic encephalopathy (HE) is a serious clinical complication, which could lead to coma and death if not appropriately managed. There is agreement on the predominant role of ammonia in the etiology of HE. Brain is one of the most critical organs affected by ammonia. The critical role of oxidative stress and its consequences in the pathogenesis of ammonia-induced brain injury have been revealed before. On the other hand, there is no promising therapeutic option against ammonia neurotoxicity. Taurine is one of the most abundant amino acids in the human body. Several pharmacological roles including brain protecting properties have been attributed to this amino acid. The current study was designed to evaluate the role of taurine supplementation on HE-induced oxidative stress in the brain tissue. Animals received thioacetamide (400 mg/kg, i.p, for three consecutive days at 24-hr intervals) as a model of acute liver failure and hyperammonemia. Several serum biochemical parameters, in addition to plasma and brain ammonia level, were monitored. Moreover, markers of oxidative stress in the brain of hyperammonemic animals were assessed. It was found that plasma and brain ammonia was increased, and serum markers of liver injury were significantly elevated in the thioacetamide-treated group. On the other hand, an increase in markers of oxidative stress, including reactive oxygen species formation, lipid peroxidation, glutathione depletion, and decreased tissue antioxidant capacity, was detected in the brain tissue of thioacetamide-treated animals. It was found that taurine treatment (250, 500, and 1000 mg/kg, i.p) alleviated brain tissue markers of oxidative stress and decreased serum biomarkers of liver injury. Furthermore, lower plasma and brain ammonia were detected in taurine-treated animals. These data suggest taurine as a potential protective agent with therapeutic capability against HE-associated central nervous system complications.
- انتشار مقاله: 11-06-1396
- نویسندگان: Akram Jamshidzadeh,Narges Abdoli,Hossein Niknahad,Negar Azarpira,Elnaz Mardani,Somayeh Mousavi,Mojgan Abasvali,Reza Heidari
- مشاهده
- جایگاه : پژوهشی
- مجله: Trends in Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Fulminant hepatic failure is a deleterious clinical complication, which leads to hyperammonemia. Ammonia is a noxious neurotoxic agent, which affects brain tissue through different mechanisms. On the other hand, it is well-known that oxidative stress and its consequences play a major role in the pathogenesis of ammonia-induced brain injury. Carnosine is a dipeptide abundantly found in the human central nervous system (CNS). This peptide is widely investigated for its neuroprotective properties. The current study aimed to evaluate the effect of carnosine supplementation on oxidative stress markers in the brain tissue of a rat model of fulminant hepatic failure and hyperammonemia. Animals received thioacetamide (400 mg/kg, i.p, for three consecutive days at 24-hr intervals) as a model of acute liver failure and hyperammonemia. Several serum biochemical parameters, in addition to plasma and brain ammonia level, were monitored. On the other hand, brain tissue markers of oxidative stress including reactive oxygen species (ROS) formation, lipid peroxidation, tissue glutathione content, and total antioxidant capacity were measured. It was found that plasma and brain ammonia was increased, and serum markers of liver injury were significantly elevated in the thioacetamide-treated group. On the other hand, an increase in markers of oxidative stress, including ROS formation, lipid peroxidation, glutathione depletion, and decreased tissue antioxidant capacity, was evident in the brain of thioacetamide-treated animals. It was found that carnosine supplementation (250, 500, and 1000 mg/kg) decreased serum markers of liver injury, mitigated brain, and plasma ammonia level, and alleviated brain tissue markers of oxidative stress. These data suggest carnosine as a potential neuroprotective agent with therapeutic capability against ammonia-induced CNS injury.
- انتشار مقاله: 11-06-1396
- نویسندگان: Akram Jamshidzadeh,Narges Abdoli,Hossein Niknahad,Negar Azarpira,Somayeh Mousavi,Elnaz Mardani,Mojgan Abasvali,Reza Heidari
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Chemistry and Chemical Engineering
- نوع مقاله: Journal Article
- کلمات کلیدی: dimedone,Acridine derivatives,Nano-reactor,Functionalized mesoporous materials
- چکیده:
- چکیده انگلیسی: 1,8-Dioxo-decahydroacridines have been synthesized by the three-component reaction of aromatic aldehydes, aromatic amines (or ammonium acetate), and dimedone in the presence of sulfonic acid functionalized nanoporous silica (SBA-Pr-SO3H) under solvent-free conditions. Excellent yields, short reaction times, mild reaction conditions, and easy work-up procedures are advantages of this green method.
- انتشار مقاله: 17-07-1391
- نویسندگان: Ghodsi Mohammadi Ziarani,Somayeh Mousavi,Negar Lashgari,Alireza Badiei,Monireh Shakiba
- مشاهده
- جایگاه : پژوهشی
- مجله: Human, Health and Halal Metrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Vegetable,Parasite,Food-borne diseases,Nematode
- چکیده:
- چکیده انگلیسی: Background and objective: Parasitic infections damage human health in different ways especially by gastrointestinal disorders. Several investigations have been done on determination of parasites in vegetables in the world. The aim of this study was to assess the rate of parasitic contamination in edible vegetables available in Yazd city (center of Iran) and suggestion of appropriate methods for prevention and control of the contamination.
Materials and methods: Four hundred samples of washed and unwashed vegetables were investigated by sedimentation and centrifugation method. The method was included to washing the vegetables by water and detergent and then rinsing several times. The sediments were centrifuged and finally stained with Lugol's iodine solution. Vegetables in the study were included to leek, parsley, coriander, dill, radishes, scallion, garden cress, basil, mint, and fenugreek.
Results and conclusion: Sixty fine out of 200 unwashed vegetables (32.5%) and three out of 200 washed vegetable (1.5%) were infected by parasites. The most contamination in the unwashed vegetables were related to terrestrial nematode, inhuman parasite eggs, and parasitic worm eggs, while their contamination dropped significantly in the washed vegetables. Among the all samples, leek and scallion were the most contaminated and radish had the least contamination. The highest level of contamination was observed in summer and the least level of contamination was observed in winter. In conclusion, parasitic contamination of the vegetables in Yazd was at moderate level. However, it is possible to prevent parasitic infection in humans by proper training of people in preparation and disinfection of vegetables.- انتشار مقاله: 25-04-1399
- نویسندگان: Somayeh Mousavi Nodushan,Mahin Ghaforzadeh,Roqieh Sadat Razavi Mahmoodabadi,Naeimeh Akramzadeh
- مشاهده