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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Ranitidine,sucralfate,Aspiration pneumonia,Microbial colonization
- چکیده:
- چکیده انگلیسی: Acidic pH of stomach, which is a normal physiological barrier against bacterial overgrowth, would increase by stress ulcer prophylaxis initiation and may lead to bacterial colonization and play as a source for infection transmission to the respiratory system which results in ventilator related pneumonia in patients admitted to the Intensive Care Units (ICUs). Therefore, finding methods to decrease the prevalence of aspiration pneumonia is an old debate. The current survey has been performed to evaluate the effect of ranitidine and sucralfate on bacterial colonization and development of aspiration pneumonia. This is a randomized clinical trial in two groups of fifteen critically ill patients older than 20 years of age admitted to the ICU of Sina Hospital, Tehran, Iran. All patients were under mechanical ventilation. One group had a regimen of 1 g sucralfate every 6 h by gavage and the other had 50 mg of intravenous ranitidine every 8 h with a loading dose of 100 mg. Gastric juice was sampled every 24 h for determining the pH and pathogen type. The gastric pH of ranitidine group was higher than of sucralfate group. Common microorganisms colonized in the gastric juice of patients were Pseudomonas, Staphylococcus aureus, Klebsiella, and Candida albicans. Aspiration pneumonia occured in 4 patients in the ranitidine group and 2 patients in the sucralfate group. Similar frequency of colonized microorganisms in the two groups suggests that the effect of pH on bacterial colonization is negligible. Therefore, concurrent consumption of ranitidine and other acid lowering medications may lower the risk of aspiration pneumonia and stress ulcer in patients taking ranitidine. If it is the case, administration of ranitidine would be preferred to sucralfate.
- انتشار مقاله: 21-09-1385
- نویسندگان: Mojtaba Mojtahedzadeh,Yunes Panahi,Mohammadreza Fazeli,Somayeh Alizadeh,Mohammad Mehdi Naghizadehd,Yashar Moharamzad
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Community Based Nursing and Midwifery
- نوع مقاله: Journal Article
- کلمات کلیدی: qualitative research,Stress,coping,hemodialysis
- چکیده:
- چکیده انگلیسی: Background: Nowadays, the prevalence of chronic diseases, such as chronic renal failure, is rising.
These patients need hemodialysis to continue their treatment, which is a stressful process. This research was conducted with the purpose of explaining coping styles in hemodialysis patients regarding stress factors based on the Lazarus and Folkman’s transactional model.
Methods: This qualitative study was conducted as a content analysis. The data collection method was
semi-structured interview with 22 patients from dialysis centers in Tehran. The data were collected
from October to January 2017. Sampling was purposive and continued until data saturation. Data were analyzed using the directed content analysis method. The process of data analysis proposed by Hsieh and Shannon’s was followed.
Results: 106 codes and 24 sub subcategories were obtained through this research and classified into 8 sub-categories of transactional stress model including: problem management, emotional regulation, social support, dispositional coping styles, positive reappraisal, revised goals, spiritual beliefs and positive events; and 3 categories of coping structures that included coping efforts, meaning-based coping and moderators.
Conclusion: Dialysis patients are making efforts to cope with their stress in order to reduce their
stress; in some cases, these efforts lead to reduction in stress, and in some cases, due to using unsound coping style, they are ineffective or even harmful. Therefore, the necessity of planning and proper interventions is felt by health care providers to control stress in dialysis patients.- انتشار مقاله: 13-12-1397
- نویسندگان: Mohtasham Ghaffari,Mohammad Ali Morowatisharifabad,Yadollah Mehrabi,Samad Zare,Jafar Askari,Somayeh Alizadeh
- مشاهده