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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Nutrition,Fasting and Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Leukocytes,fasting,Tuberculin Test
- چکیده:
- چکیده انگلیسی: Introduction: Annually, many Muslims fast during the month of Ramadan worldwide. This practice has different favorable medical and physiological effects, such as improved serum lipid profile and blood glucose level due to changes in diet and sleep patterns. It has also been hypothesized that Ramadan fasting may affect the immune system. As reported, Ramadan fasting can influence the immunoglobulin and cytokine levels. Accordingly, tuberculin skin test or purified protein derivative (PPD) test, which is a delayed-type hypersensitivity of cellular immune response, may also be affected by Ramadan fasting. Regarding this, the present study aimed to investigate the alteration of PPD test during and after Ramadan. Methods: A total of 42 males (seminary students) who fasted during Ramadan in 2006 were included in the study; however, only 28 cases completed the study. For data collection, the participants underwent blood and tuberculin tests at the fourth week of Ramadan and three months after this month. The white blood cell (WBC) count and the tuberculin induration were recorded and compared between the two intervals to evaluate the changes. Results: According to the results of the study, the mean age of the participants was 19.21±3.83 years. Furthermore, the mean tuberculin induration was 9.3±5.4 mm (size range: 2-22 mm) on the fourth week of Ramadan, which increased to 9.79±6.8 mm (size range: 3-35 mm) three months after this month (P=0.501). The mean count of WBC decreased insignificantly from 5907±1879 mcL to 5601±1362 mcL after Ramadan (P=0.334). Additionally, the mean lymphocytes count decreased significantly from 2292±520/mcL to 2023±486/mcL after this month (P=0.003). Likewise, the lymphocyte (P=0.014) and mean neutrophil percentage also reduced significantly (P<0.001). However, there was no association between PPD test and WBC, lymphocyte, or neutrophil count (P>0.05). Conclusion: As the findings of the present study indicated, Ramadan fasting induce some changes in the immune status, including lymphocyte and neutrophil percentage and count; however, it does not affect the PPD results.
- انتشار مقاله: 23-08-1395
- نویسندگان: Jafar Nasiri,Abolfazl Khoshdel,Soleiman Kheiri,Amirgholi Jafari Boroujeni
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Nutrition,Fasting and Health
- نوع مقاله: Journal Article
- کلمات کلیدی: fasting,erythrocyte sedimentation rate,Blood Cell Count
- چکیده:
- چکیده انگلیسی: Background: Ramadan fasting is an obligation for many Muslims around the world who abstain from eating and drinking for one month, which has different medical and physiological effects, such as reducing blood pressure, lipid profile, blood glucose, and body weight. It has also been hypothesized that Ramadan fasting may induce some changes in the hematologic parameters. Thus, we aimed to investigate the effect of Ramadan fasting on blood cell count (CBC), and erythrocyte sedimentation rate (ESR). Methods: In the present study, 59 adult healthy individuals, who had completed one month of Ramadan fasting were included. Fasting blood samples were analyzed for ESR, hemoglobin (Hb), hematocrit (Hct), white blood cell (WBC), platelet count (PLT), mean corpuscular Volume (MCV) and mean platelet volume (MPV), one day before, on the second and last week of Ramadan and one month after Ramadan (phase I , II, III, and IV, respectively). Results: 34 men and 25 women with an age range of 15 to 24 years participated in the study. Mean ESR increased significantly (except phase IV, in comparison phase III). Mean Hb and Hct levels were significantly greater in phase III than phase I (P<0.001). Also mean MCV decreased significantly (P<0.001). Although MPV decreased in phase II, it returned to baseline in phase IV (P=0.028). Mean WBC count decreased during all phases of the study significantly (P=0.003). Mean platelet count mildly increased during Ramadan fasting (P<0.001). Conclusion: Ramadan fasting has statistically significant effects on hematological parameters, which were within normal range.
- انتشار مقاله: 24-08-1395
- نویسندگان: Jafar Nasiri,Mehdi Mahmoudzadeh,Soleiman Kheiri,Abolfazl Khoshdel
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Veterinary Surgery
- نوع مقاله: Journal Article
- کلمات کلیدی: Lameness,Cow,Locomotion scoring,Digital dermatitis,Sole ulcer,Double sole
- چکیده:
- چکیده انگلیسی: Objectives- To evaluate the most important bovine digital lesions in Shahrekord area and its correlation with locomotion scoring. Study Design- Cross-Sectional descriptive study. Animals- five hundred and eighteen cows inspected in two seasons. Methods- Three dairy farms on three scales (1: Large, approximately 900 milking cows, 2: Medium, approximately 100 milking cows, and 3: Small, approximately 20 milking cows) were watched for lameness in 2005-2006. Locomotion scoring by Sprecher method (1-5 point scale) has been done for detection of lameness. Digital lesions in according to the area have been recorded. Sole ulcer, double sole and digital dermatitis were watched during study. Results were compared in different scores, parities, and days in milk (DIM). Results- Forty-eight percent of the inspected hooves affected with different digital lesions in autumn that was lower than spring (58.8%). No statistical difference between prevalence of each disease were recorded between autumn and spring (P>0.05). Cows in score 1-5 were as 43.6, 46.9, 52.9, 61.8 and 77.7 % respectively, the number of affected digits (AD) significantly increased with the scores. More digital lesions were recorded in cows with higher scores. Digital Dermatitis (DD), sole ulcer (SU) and double sole (DS) show a significant difference between different scores as the highest distribution recorded in score 3. By increasing the locomotion scores (LS) the percent of the lesions like DD and DS return to its original or lower than original level, but in SU the percent of the disease is still higher than percent of the animals in score 1 (P<0.05) that show the better ability of the scoring system in predicting SU. DD and DS was reduced significantly by increasing the parity, but SU significantly were increased by increasing the parity (P<0.05). No significant effect of days in milk has been detected on the prevalence of lesions understudy, but descriptively most lesion was recorded in 31-60 days after parturition. Although percent of lesions decreased by parity but this decrease was not significant. Conclusions and Clinical Relevance- Digital dermatitis is the most prevalent lesion of the hooves in Shahrekord area. Lameness scoring is a reasonable tool in investigation of the lameness that is specially capable of detecting heel horn erosions like sole ulcer.
- انتشار مقاله: 28-05-1392
- نویسندگان: Ahmad Reza Mohamadnia,Soleiman Kheiri,Hadi Aliabadi,Mojtaba Mohamaddoust,Jamshid Kabiri
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: neonate,Sepsis,Procalcitonin
- چکیده:
- چکیده انگلیسی: Background and Objective: According to the fact that neonatal infection is a challenging diagnosis field, several studies have tried to test sensitivity and specificity of diagnostic tests. This study was conducted to evaluate the sensitivity and specificity of procalcitonin (PCT) as a single early marker of neonatal sepsis. Materials and Methods: In this study, 150 neonates admitted to NICU and neonatal ward in Shahrekord Hajar hospital were enrolled. A full workup including blood cultureand other tests and PCT was conductede. Sensitivity, specificity, positive and negative predictive values for PCT was determined. Results: It was found out that 8 patients had definite infection, 15 patients had possible infection, and 127 patients had no infection. Although PCT was not able to significantly differentiate between those with definite and possible infections (p>0.05), but there was a significant difference for frequency of abnormal PCT between non-infectious patients and other patients. Sensitivity, specificity, positive and negative predictive values of PCT was 87.5%, 87.4%, 30.4%, 99.1%, and 87.41% respectively. Conclusion: Beside the limitation of the sample size, the satisfactory diagnostic characteristics of PCT highlight it as a good measure for diagnosis of neonatal sepsis. Further studies are essential to be carried out.
- انتشار مقاله: 07-07-1393
- نویسندگان: Abolfazl Khoshdel,Mahdi Mahmoudzadeh,Soleiman Kheiri,Reza Imani,Ghorbanali Shahabi,Ebrahim Saedi,Elham Taheri
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Neonatology
- نوع مقاله: Journal Article
- کلمات کلیدی: Surfactant,Keywords: Neonatal respiratory distress syndrome,Surfactant without intubation
- چکیده:
- چکیده انگلیسی: Background: The cornerstone of the treatment of respiratory distress syndrome (RDS) is respiratory support and surfactant replacement therapy. The administration of surfactant through a thin intratracheal catheter is one of the methods used to reduce one of the standard technique complications of a surfactant injection (Intubation-Surfactant-Extubation method [INSURE]). The aim of this study was to compare the effectiveness of this method on the treatment of RDS in neonates with one of the INSURE technique.
Methods: In this double blind clinical trial, 104 neonates with RDS were randomly allocated to two groups, one group received surfactant via an endotracheal tube (INSURE) and the other received surfactant without intubation (SWI) via a thin intratracheal catheter. Subsequently the outcomes of the two groups were compared.
Results: The incidence of hypoxemia during surfactant administration was significantly lower in the SWI group (11.5%) than in the INSURE group (28.8% , P< 0.05). no significant difference was observed in the need for intubation and mechanical ventilation during the first 72 hours of life, the duration of mechanical ventilation, the need for nasal continuous positive airway pressure (NCPAP), the need for oxygen, the incidence of bronchopulmonary dysplasia, intraventricular hemorrhage, pulmonary hemorrhage ,and death in the two groups.
Conclusion: Administration of surfactant through a thin intratracheal catheter is a safe and easy technique. This method is as effective as the INSURE method in improving the outcomes of RDS treatment.- انتشار مقاله: 10-09-1397
- نویسندگان: Roya Choupani,Ghobad Mashayekhy,Majid Hmidi,Soleiman Kheiri,Marzieh Khalili Dehkordi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی:
- انتشار مقاله: 09-09-1394
- نویسندگان: Jafar Nasiri,Soleiman Kheiri,Abolfazl Khoshdel,Amirgholi Jafari Boroujeni
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: children,Bacillus Calmette Guerin,CD119,Interferon gamma,Lymphadenopathy
- چکیده:
- چکیده انگلیسی: Background: Lymphadenitis is the most common complication of BCG vaccination in children. Interferon-gamma (IFN-γ) plays a key role in immune response to Mycobacterial infections. In this study, the relationship of serum levels of IFN-γ and its receptor (CD119) to development of Bacillus Calmette Guerin (BCG) axillary lymphadenopathy was investigated.
Materials and Methods: In this case-control study, 45 children with axillary lymphadenopathy and 45 healthy children matched by age and sex were included. Two ml peripheral blood was collected in tubes containing anticoagulants. Then, level of IFN-γ was measured by ELISA and the level of CD119 expression in the peripheral blood mononuclear cell (PBMC) was measured by flow cytometry. Data were analyzed using SPSS software version 22.0.
Results: Totally, 90 children were enrolled in this study, which consisted of 30 girls and 60 boys. The mean age of participants was 14.5±6.5 months in case group and 15.2±7.1 months in control group, respectively (p=0.61). The level of IFN-γ was significantly lower in case group than in control group (p<0.001), but no significant difference was observed in PBMC percentage between the two groups (p>0.05). There was no significant relationship of age and sex to BCG (INF and PBMC) lymphadenopathy (p>0.05).
Conclusion: Based on the results, IFN-γ level was significantly lower in the BCG lymphadenopathy group than in the control group. Levels of IFN-γR (CD119 cellular level in PBMC) in two groups did not show a significant relationship.- انتشار مقاله: 18-08-1398
- نویسندگان: Mohammad Ali Zamani,Hajar Sorani,Ali Asghar Rabiei,Mehdi Ghatreh-Samani,Soleiman Kheiri,Nika Khoshdel,Abolfazl Khoshdel
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Antiviral activity,Influenza A virus,Peganum harmala L
- چکیده:
- چکیده انگلیسی: Objective: Influenza A virus infections are still a major health problem and the choices available for the control and treatment of the disease are limited. This research evaluated in vitro and in vivo antiviral effects of Peganum harmala L. seeds (PHS) extract against influenza A virus.
Materials and Methods: In this research, in vitro anti-influenza A virus activity of the extract was assessed in Madin-Darby canine kidney (MDCK) cells. In order to evaluate anti-influenza activity of PHS extract in vivo, BALB/c mice were infected with 5LD50 of mouse-adapted influenza virus (H1N1; PR8) and received 200 mg/kg/day of PHS extract or 20 mg/kg/day oseltamivir. Lungs of seven mice per group were removed on day 3 post-infection and lung virus titers were determined by qRT-PCR. Mice survival, body weights and general conditions were observed for up to 14 days post-infection.
Results: The results demonstrated that, the ethanolic extract of PHS possesses high activity against influenza virus with IC50 value of 15.7 (CI95%:11.7-21) μg/ml in MDCK cells. Our results also showed that, oral administration of PHS extract (200 mg/kg/day) or oseltamivir (20 mg/kg/day) to infected mice, increased the survival rate, reduced body weight loss, and decreased lung virus titer.
Conclusion: Based on our findings, P. harmala seeds extract can inhibit influenza A virus replication in vitro and in vivo. Therefore, isolation and characterization of the plant’s active compounds and investigation of the underlying mechanisms of its antiviral action are highly suggested.- انتشار مقاله: 09-12-1395
- نویسندگان: Mohammad-Taghi Moradi,Ali Karimi,Fatemeh Fotouhi,Soleiman Kheiri,Ali Torabi
- مشاهده