در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Evidence Based Care Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: quality,cancer-related fatigue,Clinical practice guidelines
- چکیده:
- چکیده انگلیسی: Background: Improvement of the quality ofcancer-related fatigue clinical practice guidelines (CPGs) is an important issue in oncology.
Aim: This study aimed to determine the methodological quality of CPGs about cancer-related fatigue management using the AGREE II instrument.
Method: This study involved a systematic search, followed by a descriptive study, to evaluate the methodological quality of CPGs about CRF using the AGREE II instrument in 2018. A comprehensive search was conducted on different websites and databases to find the eligible published guidelines from the observation time to Jan 2018. After screening the guidelines based on eligibility criteria, the selected CPGs were assessed by five independent appraisers by means of the updated AGREE II instrument developed in 2013.
Results: According to the results, applicability and editorial independence domains had obtained low quality scores. However, the scores of the rest of the domains were indicative of a favorable quality level.
Implications for Practice: It is essential to improve the quality of CRF CPGs and design high-quality CPGs especially in terms of applicability and editorial independence domains.
- انتشار مقاله: 24-02-1397
- نویسندگان: Shahin Salarvand,Simin Hemati,Payman Adibi,Fariba Taleghani,Reza Ghanei Gheshlagh
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Prostate cancer,Polymorphism,insulin-like growth factor 1
- چکیده:
- چکیده انگلیسی: Background:Prostate cancer is increasing among Iranian men and gene polymorphisms may play a role in the development of prostate cancer. Insulin-like growth factor 1 (IGF1) gene polymorphisms have been deeply explored in different malignancies. In this study, we aimed to explore the association of IGF1 CA repeat length polymorphism with the risk of prostate cancer development in Isfahan province of Iran. Method:The total blood of 100 prostate cancer patients and the equivalent matched control individuals were collected. DNA extraction was followed by IGF1 promoter polymorphism amplification. Genotyping was performed using polyacrylamide gel electrophoresis and sequencing was performed. Results:According to the results, IGF1 promoter polymorphic site showed six different alleles ranging from 17-22 CA repeats among our studied population. Comparing SL heterozygotes with both homozygotes, a significant increase in RR value (RR=4.5, p=0.031) was observed. Although age adjustment and family history did not elevate the RR value, but a significantly elevated risk of prostate cancer (RR= 3.143, p=0.002) was shown when we compared SS patients with LL ones according to their BPH history. Conclusion:In conclusion, carriers of (CA)17 allele could be at a higher risk of prostate cancer development and being SL heterozygotes could increase the risk of BPH development in our studied population.
- انتشار مقاله: 30-10-1396
- نویسندگان: Hoda Bazafkan,Seyed-morteza Javadirad,Manoochehr Tavasoli,Simin Hemati
- مشاهده
- جایگاه : پژوهشی
- مجله: Evidence Based Care Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: quality,cancer-related fatigue,Clinical practice guidelines
- چکیده:
- چکیده انگلیسی: Background: Improvement of the quality ofcancer-related fatigue clinical practice guidelines (CPGs) is an important issue in oncology.
Aim: This study aimed to determine the methodological quality of CPGs about cancer-related fatigue management using the AGREE II instrument.
Method: This study involved a systematic search, followed by a descriptive study, to evaluate the methodological quality of CPGs about CRF using the AGREE II instrument in 2018. A comprehensive search was conducted on different websites and databases to find the eligible published guidelines from the observation time to Jan 2018. After screening the guidelines based on eligibility criteria, the selected CPGs were assessed by five independent appraisers by means of the updated AGREE II instrument developed in 2013.
Results: According to the results, applicability and editorial independence domains had obtained low quality scores. However, the scores of the rest of the domains were indicative of a favorable quality level.
Implications for Practice: It is essential to improve the quality of CRF CPGs and design high-quality CPGs especially in terms of applicability and editorial independence domains.
- انتشار مقاله: 24-02-1397
- نویسندگان: Shahin Salarvand,Simin Hemati,Payman Adibi,Fariba Taleghani,Reza Ghanei Gheshlagh
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Expression,Gastric cancer,Polymorphism,IL-6,ASIC1
- چکیده:
- چکیده انگلیسی: Abstract: Gastric cancer is one of the most common upper gastrointestinal malignancies. Some Iranian provinces,
such as in the northern and northwestern areas, are at a high risk, whereas the central and western provinces are at
a medium and the southern regions at low risk. This study was carried out to estimate the impact of the expression
patterns of ASIC1 and IL-6 genes and the IL-6rs-174 and ASIC1rs 75624685 polymorphisms in the pathogenesis of
gastric cancer. Materials and methods: Tetra-ARMS PCR was employed to analyze the polymorphism status of the
ASIC1 and IL-6 genes with 85 paraffin-embedded tissue blocks from cases and 117 normal blood samples as controls.
We also investigated mRNA expression levels of these genes in 12 cases and controls using real-time PCR. Results:
Our results showed a significant association between expression of ASIC1 and elevated risk of gastric cancer (p<0.001).- انتشار مقاله: 09-11-1396
- نویسندگان: Abdulkuddous Heydari-Mehrabadi,Dor Mohammad Kordi-Tamandani,Tayebeh Baranzehi,Simin Hemati
- مشاهده
- جایگاه : پژوهشی
- مجله: Annals of Colorectal Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Pathology,Colorectal neoplasms,Clinical characteristics,Survival
- چکیده:
- چکیده انگلیسی: Context: Colorectal cancer is one of the most common cancers and the leading cause of cancer death in Iran. This study aimed to identify the clinical and pathological characteristics, as well as survival rate of colorectal cancer in Iran.
Evidence Acquisition: The articles published in PubMed without language and time restrictions were included in this review. Only original clinical articles were included in the review and non-clinical studies, including cellular, molecular, genetics, and animal reports, were excluded. The case reports, letters, reviews, and clinical reports with less than 100 patients were excluded, as well. All the clinical data regarding the patients’ demographics, tumor characteristics, and survival rate were collected.
Results: A total of 178 studies were identified at the initial step of literature search. After applying the inclusion and exclusion criteria, 27 studies, including 37901 patients were eligible. The mean age of the patients was 57.2 years, and the male-female ratio was 1.38. Colon, rectum, and rectosigmoid junction accounted for 58%, 28%, and 14% of all colorectal primary sites, respectively. Moreover, the average proportion of the patients with stages 0-I, II, III, and IV was 9%, 39%, 36%, and 16%, respectively. Besides, tumor grades 1, 2, and 3 were reported in 52%, 37%, and 11% of the patients, respectively. Adenocarcinoma (96.8%) was the most frequent histological type. The mean and median survival rate was 80.1 and 55.2 months, respectively. Additionally, the average 5-year overall survival rate was 52.5%.
Conclusions: In Iran, colorectal cancer tends to manifest at locally advanced stage with poor prognosis. Therefore, public health strategies, such as screening programs, should be planned for early detection of this aggressive neoplasm.- انتشار مقاله: 08-10-1392
- نویسندگان: Sareh Hoseini,Leila Moaddabshoar,Simin Hemati,Mohammad Mohammadianpanah
- مشاهده