در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Advanced Herbal Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Rat,Hepatoprotective,Homalium letestui
- چکیده:
- چکیده انگلیسی: Background and aims: Homalium letestui Pellegr (Flacourtiaceae) is used traditionally by the Yorubas of Western Nigeria as an antidote and by the Ibibios of Southern Nigeria to treat stomach ulcer, malaria and other inflammatory diseases. The aim of this study is to determine the hepatoprotective effects of ethanol extract of H. letestui stem (250-750 mg/kg) on carbon tetrachloride (CCl4)-induced liver injury in rats. Methods: A total of 36 rats were divided into six groups of 6 animals each. Group 1 was administered with normal saline (10 ml/kg) for eight days, group 2 received CCl4, group 3 served as the standard group, while groups 4, 5 and 6 were administered p.o with 250, 500 and 750 mg/kg of H. letestui stem extract, respectively, for 8 days. Liver function and histopathological parameters were investigatesd to assess hepatoprotective activity of the extract. Results: Administration of the stem extract (250-750 mg/kg body weight) caused significant (P<0.05 – 0.001) reductions in levels of liver enzymes (ALT, AST and ALP), total cholesterol, direct and total bilirubin and elevation of serum levels of total protein and albumin. Optimal effects on most parameters were observed at 500 mg/kg dose. The effects of the extract/fraction were comparable to that of the standard drug used. Thus, the local use of this plant, at appropriate doses, as an antidote could be supported. Conclusions: The plant may provide protection against substances that react with membrane lipids to induce peroxidation and subsequent dysfunction of membranes by acting as an effective scavenger of reactive oxygen species. This positive effect may be similar to the established effects of certain substances such as silymarin, vitamin E, vitamin C and other free radical scavengers that reduce the toxic effects of CCl4, especially on the liver.
- انتشار مقاله: 02-06-1396
- نویسندگان: Simeon Oyepata Joseph,Jude Okokon,Opeyemi Tosin Joseph
- مشاهده
- جایگاه : پژوهشی
- مجله: Advanced Herbal Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Rats,Homalium letestui,nephroprotective
- چکیده:
- چکیده انگلیسی: Background and aims: The kidney is a very vital organ that is responsible for regular elimination of unwanted substances from the body. It is frequently exposed to conditions that expose it to damage. There are not enough drugs in the market to protect or treat the kidney against these deleterious conditions. Homalium letestui has been used in traditional medicine as an antidote. This study aims to investigate the nephroprotective activity of ethanol stem extract of Homalium lestetui against gentamicin-induced rat’s kidney injury. Methods: Thirty-six (36) adult male albino rats were used for this study. Animals in group I served as the control with normal saline, group II received gentamicin (100 mg/kg), group III received Silymarin (100 mg/kg), while group IV, V and VI where administered 250, 500 and 750 mg/kg of ethanol stem extract of Homalium letestui along with gentamicin 100 mg/kg for 8 days. The nephroprotective effect of the extract was evaluated by the assay of kidney function parameters such as serum urea, creatinine, electrolytes (K+, Na+, Cl- and HCO-3) and histopathological examination of the kidney. Results: Homalium letestui caused significant p≤ 0.05 dose-dependent reduction in the level of serum urea, creatinine, and electrolytes in rat’s kidney when compared to the control. The chemical pathological changes were consistent with histopathological observations suggesting marked the nephroprotective effect of the stem extract of H. letestui. Conclusion: The result of the study suggests that the plant has kidney protective ability which supports its traditional use as an antidote
- انتشار مقاله: 08-07-1396
- نویسندگان: Simeon Oyepata Joseph,JUDE EFIOM OKOKON,Opeyemi Tosin Joseph
- مشاهده