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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Cholangiocarcinoma,Biliary intraepithelial neoplasia,biliary cirrhosis,hepatolithiasis,liver atrophy
- چکیده:
- چکیده انگلیسی: Background: Cholangiocarcinoma and secondary biliary cirrhosis can develop after liver resection for hepatolithiasis and are causes of hepatolithiasis-related death. We determined potential risk factors for hepatolithiasis-related death and subsequent cholangiocarcinoma, including precancerous lesions such as biliary intraepithelial neoplasia (BilIN) and intraductal papillary neoplasm of the bile duct, in patients undergoing liver resection for hepatolithiasis. Methods: The study cohort included 62 patients who underwent liver resection for hepatolithiasis without concomitant cholangiocarcinoma and had surgical specimens available for pathological examination. Univariate and multivariate analyses were conducted to examine risk factors associated with subsequent cholangiocarcinoma after hepatolithiasis and hepatolithiasis-related death. In 28 patients with BilIN lesions, the specimens were immunohistochemically stained for γ-H2AX and S100P. Results: In the study cohort, the causes of death were subsequent cholangiocarcinoma, biliary cirrhosis, and other diseases in 5, 3, and 7 patients, respectively. Liver atrophy, precancerous lesions, postoperative repeated cholangitis, and jaundice for ≥1 week during the follow-up period were risk factors for hepatolithiasis-related death. Multivariate analysis showed that liver atrophy and precancerous lesions were independent risk factors for hepatolithiasis-related death. Liver atrophy or precancerous lesions were also risk factors for subsequent cholangiocarcinoma by univariate analysis. The positive expression of γ-H2AX and S100P was observed in 18 and 14 of the 28 BilIN lesions, respectively. Conclusions: Liver atrophy and precancerous lesions with malignant transformation were risk factors not only for subsequent cholangiocarcinoma but also hepatolithiasis-related death after liver resection for hepatolithiasis, indicating that long-term follow-up is necessary even after liver resection in patients harboring these risk factors.
- انتشار مقاله: 02-07-1399
- نویسندگان: Toru Miyazaki,Hiroji Shinkawa,Shigekazu Takemura,Shogo Tanaka,Ryosuke Amano,Kenjiro Kimura,Go Ohira,Kohei Nishio,Masahiko Kinoshita,Jun Tsuchi,Atsushi Ishihara,Shimpei Eguchi,Daisuke Shirai,Takatsugu Yamamoto,Kenichi Wakasa,Norifumi Kawada,Shoji Kubo
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Hepatocellular carcinoma,Hepatic resection,hepatectomy,BCLC stage B,Intermediate stage
- چکیده:
- چکیده انگلیسی: Background: Hepatic resection (HR) is not recommended for intermediate-stage hepatocellular carcinoma (HCC) by the Barcelona Clinic Liver Cancer criteria. We examined the prognostic factors of HR for intermediate-stage HCC and developed new HR criteria for intermediate-stage HCC. Methods: A total of 110 patients who underwent HR without any prior treatment for intermediate-stage HCC between January 2007 and December 2012 were enrolled at eight university hospitals. The outcomes and prognostic factors of HR were evaluated to develop new HR criteria. Results: In terms of tumor size and number, the most significant prognostic factors were within the up-to-seven criteria. Furthermore, serum albumin level ≥35 g/L and serum alpha-fetoprotein (AFP) level
- انتشار مقاله: 04-12-1398
- نویسندگان: Hiroya Iida,Masaki Kaibori,Fumitoshi Hirokawa,Yoshihiro Inoue,Masaki Ueno,Kousuke Matsui,Morihiko Ishizaki,Shogo Tanaka,Shigekazu Takemura,Takeo Nomi,Daisuke Hokutou,Takehiro Noda,Hidetoshi Eguchi,Takuya Nakai,Hiromitsu Maehira,Haruki Mori,Masaji Tani,Shoji Kubo
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Prognostic factor,Hepatic resection,CRP/Alb ratio,Intrahepatic cholangiocarcinoma
- چکیده:
- چکیده انگلیسی: Objective: The present study aimed to investigate the impact of preoperative C-reactive protein to albumin (CRP/Alb) ratio on the long-term outcomes of patients with intrahepatic cholangiocarcinoma (ICC). Methods: 82 patients who underwent hepatic resection for mass-forming type of ICC were evaluated. The relationship between preoperative CRP/Alb ratio and survival outcomes was investigated. Results: The optimal cutoff value of CRP/Alb ratio for assessing overall survival (OS) was determined as 0.089. Univariate analysis for recurrence-free survival (RFS) showed that CRP/Alb ratio >0.089, carbohydrate antigen 19-9 (CA 19-9) >37 U/mL, lymph node metastasis, vascular invasion, and multiple tumors were significantly associated with postoperative recurrence. On multivariate analysis, the independent prognostic factors identified were CRP/Alb ratio >0.089 (p < 0.001), lymph node metastasis (p = 0.006), and multiple tumors (p < 0.001). Univariate analysis for OS showed that CRP/Alb ratio >0.089, CA 19-9 >37 U/mL, lymph node metastasis, vascular invasion, multiple tumors, and positive surgical margin were significantly associated with overall death. On multivariate analysis, the independent prognostic factors identified were CRP/Alb ratio >0.089 (p < 0.001), lymph node metastasis (p = 0.01), and multiple tumors (p = 0.005). Conclusion: Preoperative CRP/Alb ratio may predict poor long-term outcomes after hepatic resection in patients with ICC.
- انتشار مقاله: 30-02-1399
- نویسندگان: Tokuji Ito,Hiroji Shinkawa,Shigekazu Takemura,Shogo Tanaka,Takayoshi Nishioka,Toru Miyazaki,Atsushi Ishihara,Shoji Kubo
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Lymph node metastasis,Occupational cholangiocarcinoma,Biliary intraepithelial neoplasia,Intraductal papillary neoplasm of the bile duct,Fluorine-18 fluorodeoxyglucose positron emission tomography
- چکیده:
- چکیده انگلیسی: Objective: The present study aimed to identify the clinical significance of fluorine-18 fluorodeoxyglucose positron
emission tomography (FDG-PET) imaging in patients with occupational cholangiocarcinoma. Methods: This study
included 10 men with occupational cholangiocarcinoma who were former or current workers at a printing company in
Osaka, Japan. Of the 10 patients, 2 had 2 main tumors and 1 had 3 main tumors. Twelve FDG-PET imaging findings
in the 10 patients could be analyzed. We evaluated the relationships between FDG-PET imaging parameters and
clinicopathological findings of occupational cholangiocarcinoma. Results: Abnormal FDG uptake was observed in 8 of
the 14 main tumors, with maximum standardized uptake values ranging from 2.9 to 11.0, and the sensitivity was 57.1%.
Four patients had lymph node metastases, and abnormal marrow uptake was detected in all these patients. Although
precancerous lesions, such as biliary intraepithelial neoplasia (BilIN) and intraductal papillary neoplasm of the bile
duct (IPNB) without any invasion, were not detected, abnormal FDG uptake was demonstrated in 2 of 4 patients with
IPNB having an associated invasive carcinoma.Conclusions: Although FDG-PET may be useful for assessing tumor
progression factors, such as lymph node metastasis, it cannot accurately detect precancerous lesions, such as BilIN
and IPNB without invasive carcinoma.- انتشار مقاله: 10-01-1397
- نویسندگان: Masahiko Kinoshita,Shigekazu Takemura,Shogo Tanaka,Hiroji Shinkawa,Genya Hamano,Tokuji Ito,Masaki Koda,Takanori Aota,Yasuni Nakanuma,Yasunori Sato,Shoji Nakamori,Akira Arimoto,Takatsugu Yamamoto,Hideyoshi Toyokawa,Shoji Kubo
- مشاهده