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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Testosterone,Gonadotropins,Echium,Male fertility agents,Semen analysis
- چکیده:
- چکیده انگلیسی: Background: Iranian borage, Echium amoenum, is believed to improve reproduction according to folk medicine. Although E. amoenum distillate known as “Aragh Gav-zaban” is widely consumed as a safe and natural remedy, its possible effects on fertility have not yet been scientifically examined. The present study aimed to investigate the effects of borage distillate (BD) on reproductive parameters of male mice.Methods: In this experimental study, 30 adult male Mus musculus mice (30-35 g) were equally divided into three groups. The control group received distilled water (DW) for five weeks and the other two groups, BD1/2 and BD1/4, received borage distillate of 1/2 dilution (150±2.5 ml/kg/day) and 1/4 dilution (75±1.25 ml/kg/day), respectively, ad libitum for three weeks and DW for 2 weeks. On the day 35, mice were sacrificed, sperm analysis was performed, and sera were collected to evaluate gonadotropins, testosterone, and toxicity parameters. The left testis was excised for stereological study and the right testis was used to evaluate androgen receptor (AR) gene expression. Results: The administration of BD1/2 significantly increased serum FSH (P=0.004), LH (P=0.025), testosterone (P=0.014), the percentage of motile (P=0.011); slow progressive (P=0.001), coiled tail (P<0.001) sperms, and the number of Leydig cells (P=0.008) compared to the control group. Treatment with BD1/4 significantly increased sperm count (P=0.044) and motile sperms percentage (P=0.040) compared to the control group too. The administration of BD revealed no significant effects on toxicity parameters and AR gene expression.Conclusion: The findings of the present study showed that the consumption of borage distillate, as a safe herbal remedy, improves hormonal and sperm parameters in male mice.
- انتشار مقاله: 08-05-1396
- نویسندگان: Shima Fakher,Atefeh Seghatoleslam,Ali Noorafshan,Saeid Karbalay-Doust,Maryam Rahmanifard,Mojtaba Rashidi
- مشاهده
- جایگاه : پژوهشی
- مجله: Annals of Colorectal Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Colorectal cancer,biobank,biorepository,biobank network
- چکیده:
- چکیده انگلیسی: Background: Cancer research is highly dependent of large amount of data and high quality samples which can be provided by networks to enable large-scale multi-center research projects. Biologic materials, such as blood, tissue samples, DNA, body fluids and the related data obtained in cohorts and clinical trials are valuable sources for research which should be managed by policies and standard operating procedures as biorepositories or biobanks.
Methods and evidence acquisition: The authors investigated and summarized pubmed database articles using biobanks and describing the policies.
Conclusion: biobanking as a young discipline in different countries needs new technologies, standards and harmonization. In this review article, we have an overview on biorepository, cancer biobanking and the emerging registry in Iran.
Background: Cancer research is highly dependent of large amount of data and high quality samples which can be provided by networks to enable large-scale multi-center research projects. Biologic materials, such as blood, tissue samples, DNA, body fluids and the related data obtained in cohorts and clinical trials are valuable sources for research which should be managed by policies and standard operating procedures as biorepositories or biobanks.
Methods and evidence acquisition: The authors investigated and summarized pubmed database articles using biobanks and describing the policies.
Conclusion: biobanking as a young discipline in different countries needs new technologies, standards and harmonization. In this review article, we have an overview on biorepository, cancer biobanking and the emerging registry in Iran.- انتشار مقاله: 30-10-1398
- نویسندگان: Shima Fakher,Seyed Vahid Hosseini,Mozhdeh Zamani,Leila Ghahramani,Pooneh Mokaram Mokaram
- مشاهده