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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: oral cancer,oxidative stress,selenium,trace elements,cancer biomarkers
- چکیده:
- چکیده انگلیسی: In the perspective of selenium as an antioxidant and anti-carcinogen, so far no strong intervention trials with
selenium over radiation-treated oral squamous cell carcinoma cases have been conducted, to examine the response of
the disease and the subsequent biochemical alterations. In the present study, untreated oral cancer cases (Gp II) were
compared with radiation-treated groups with and without selenium (Gp IIa, IIb), forward to find the trace elements
and cancer biomarkers status, at a follow-up of 6 months. Severe alteration in the trace elements levels of Se, Cu,
Fe, Zn, Na, K, Ca, Cl, were noticed in Gp II. Though Gp IIa showed slight improvement, administration of selenium
(Gp IIb) improved the level of all these elements to a greater extent (p<0.001). GpII and IIa showed increased level of
bio markers 5’-nucleotidase, PschE, LAP, γ-GTP, LDH, SGOT, SGPT, ACP, ALP, CPK, TNF, CEA, AFP, Scc-Ag.
The greater extent of restitution to near normalcy was observed in patients given selenium (Gp IIb) (p<0.001). Owing to
the fact that selenium scavengers oxidants and hence decelerate carcinogenesis by eliminating tumors, so the tumor
released constituents into the systemic circulation declined significantly. Therefore, the outcome of the study suggests
selenium as a valuable therapeutic measure as adjuvant for oral cancer patients undergoing cancerocidal radiotherapy.- انتشار مقاله: 04-05-1396
- نویسندگان: Sonaa Elango,Shila Samuel,Zenith Khashim,Usha Subbiah
- مشاهده