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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Immunization,Indonesia,human papillomavirus vaccine,Elementary School,post marketing
- چکیده:
- چکیده انگلیسی: Objective: Quadrivalent human papillomavirus (QHPV) vaccine has been advised for routine vaccination of
pre-adolescent girls globally, and a two-dose QHPV vaccination schedule has been introduced in Indonesia to vaccinate
5th and 6th grade elementary school female students. This post-marketing surveillance study evaluated the possible adverse
events following immunization with the two-dose QHPV vaccine in Indonesia. Methods: Girls studying in grade 6
of five designated elementary schools in Jakarta, receiving their 2nd dose of QHPV vaccine and provided informed
consent (represented by their parents), were included in the study. Students who had received other immunizations
either simultaneously or day, after the immunization were recorded using a Children Symptom Dairy Card/Kartu Harian Anak Sekolah (KHAS/
Student Daily Card). Results: A total of 500 students from 20 schools were included. No serious adverse events were
reported during the study period. Fever (systemic reaction) of mild intensity was noted in 1.6 % (n=8) of participants,
which subsided after day 6. Local reactions such as pain, redness and swelling were noted in 59.6% (n=295), 23.6%
(n=118), and 17.2% (n=86) of participants, respectively. These resolved without any intervention in majority of the
cases after day 5. Conclusion: These results along with the safety data from the pre-licensure clinical trials confirm
the favorable safety profile of QHPV vaccine in pre-adolescent girls. The school-based two-dose QHPV immunization
program in Indonesia is a safe and effective strategy for optimizing HPV vaccine coverage among pre-adolescent girls.- انتشار مقاله: 29-06-1397
- نویسندگان: Hindra Irawan Satari,Julitasari Sundoro,Andrijono Andrijono,Sri Rezeki Hadinegoro,Syafriyal Syafriyal,Gertrudis Tandy,Sherli Karolina
- مشاهده