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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: mesenchymal stem cell,sorafenib,Hepatocellular carcinoma,HepG2
- چکیده:
- چکیده انگلیسی: Objective: Hepatocellular carcinoma (HCC) is the most common liver malignancy. Sorafenib is the first-line
systemic treatment for advanced HCCs. However, due to safety concerns, researchers are now looking for ways to boost
the efficacy of the medication. One approach for reducing toxicity is combining sorafenib with other agents so that a
lower dose of sorafenib is required. Mesenchymal stromal cells (MSCs) can have an inhibitory effect on HCC tumor
growth. Mesenchymal Stem Cell-Conditioned Medium (MSC-CM) is the substance extracted from MSC culture and
contains most of the potential cytokines secreted by MSCs. We, therefore, anticipated a synergistic Antitumor Effect
of sorafenib in Combination with MSC-CM. In this study, we used HepG2 as our target cell lines. Methods: HepG2
cells were treated with sorafenib alone and with sorafenib + MSC-CM. CCK-8 assay was used to evaluate and compare
the inhibition of cell growth between the two groups with different treatments. Results: The combination treatment of
cell lines with sorafenib and MSC-CM had significantly reduced the values of IC50 compared to the use of sorafenib
alone (3.4 vs. 2.7 respectively). Conclusion: This study suggests that a combination of sorafenib with MSC-CM can
synergistically suppress the growth of HCC cells.- انتشار مقاله: 07-06-1397
- نویسندگان: Iman Seyhoun,Saieh Hajighasemlou,Jafar Ai,Faezeh Hosseinzadeh,Milad Mirmoghtadaei,Seyed Moein Seyhoun,Benyamin Parseh,Shahrokh Abdolahi,Zeinab Ghazvinian,Mahdi Shadnoush,Javad Verdi
- مشاهده