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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Food & Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Cardiovascular,Overhydration,Water deprivation,Water restriction
- چکیده:
- چکیده انگلیسی: Fluid balance is essential for life. Some studies have shown an association between high intake of water and a low risk of cardiovascular diseases. However, the evidence is insufficient or inconsistent to draw substantial conclusions. The author's objective was to review previous studies addressing the influence of drinking water and hydration status on the cardiovascular system. The PubMed and Google Scholar databases were searched using relevant terms. Animal and human studies in the English language which were highly relevant to the topic were selected and summarized. Drinking about half a liter of water rapidly raises sympathetic activity as much as classic sympathetic stimuli such as caffeine and increases plasma norepinephrine leading to peripheral vasoconstriction. However, cardiac vagal tone enhancement with water ingestion buffers the pressor effects of sympathetic activation. Dehydration leads to mild hypernatremia which gradually causes changes such as increased blood viscosity, hemoconcentration, inflammatory signals, platelet activation and aggregation, adhesive properties of endothelial cells, thrombogenesis, and so on, all of which are harmful to the cardiovascular system. Overhydration can result in water intoxication and increase coagulability. Both dehydration and overhydration are associated with several adverse effects on the cardiovascular system. However, the data regarding how much water can reduce the risk of heart disease is limited and the results are also controversial. More research is needed to confirm the observed associations between hydration status and cardiovascular diseases.
- انتشار مقاله: 13-11-1398
- نویسندگان: Shahnaz Shekarforoush,Mina Fardaee
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Opium,Morphine,Learning,Morris Water Maze,Co-administration,Nicotine dependency
- چکیده:
- چکیده انگلیسی: Objective(s): Smoking opium/cigarette is a global health concern. The aim of this study was to examine learning and memory of rat male offsprings whose mothers had been exposed to either opium or morphine with nicotine during pregnancy. Materials and Methods: Wistar rats were used for the experiments. In the female rats, opium, morphine and nicotine dependencies were induced by daily injections of drug solution for 10 days before mating. Spatial memory was tested by Morris water maze test in male pups at the postnatal day 60. The duration that took until the rats found the platform in the maze and also their swimming speed were recorded. Results: An increase in the platform finding duration was observed for the pups of dependent mothers in comparison with the control in the training trial (P<0.05). Prenatal exposure to opium/morphine and nicotine significantly decreased the time spent in the trigger zone to find the hidden platform (P<0.05) but had no significant effect on the swimming speed in the probe test. However, no significant difference was observed in the learning and memory behavior of offspring whose mothers received morphine, opium, nicotine or the co-administration of either morphine or opium with nicotine. Conclusion: The present study showed that the opium, morphine and nicotine abuse and co-administration of opium/morphine with nicotine during pregnancy may cause deficits in spatial learning of male rat offspring. Based on our data, no synergistic effects of co-drug administration were observed on learning and memory in male rat offspring.
- انتشار مقاله: 02-07-1393
- نویسندگان: Gholamreza Sepehri,Shahrnaz Parsania,Mousa‐Al‐Reza Hajzadeh,Tahereh Haghpanah,Vahid Sheibani,Kouros Divsalar,Shahnaz Shekarforoush,Mohammad Reza Afarinesh
- مشاهده
- جایگاه : پژوهشی
- مجله: Food & Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Cardiovascular,Overhydration,Water deprivation,Water restriction
- چکیده:
- چکیده انگلیسی: Fluid balance is essential for life. Some studies have shown an association between high intake of water and a low risk of cardiovascular diseases. However, the evidence is insufficient or inconsistent to draw substantial conclusions. The author's objective was to review previous studies addressing the influence of drinking water and hydration status on the cardiovascular system. The PubMed and Google Scholar databases were searched using relevant terms. Animal and human studies in the English language which were highly relevant to the topic were selected and summarized. Drinking about half a liter of water rapidly raises sympathetic activity as much as classic sympathetic stimuli such as caffeine and increases plasma norepinephrine leading to peripheral vasoconstriction. However, cardiac vagal tone enhancement with water ingestion buffers the pressor effects of sympathetic activation. Dehydration leads to mild hypernatremia which gradually causes changes such as increased blood viscosity, hemoconcentration, inflammatory signals, platelet activation and aggregation, adhesive properties of endothelial cells, thrombogenesis, and so on, all of which are harmful to the cardiovascular system. Overhydration can result in water intoxication and increase coagulability. Both dehydration and overhydration are associated with several adverse effects on the cardiovascular system. However, the data regarding how much water can reduce the risk of heart disease is limited and the results are also controversial. More research is needed to confirm the observed associations between hydration status and cardiovascular diseases.
- انتشار مقاله: 13-11-1398
- نویسندگان: Shahnaz Shekarforoush,Mina Fardaee
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Rat,Thioacetamide,Phenolic compounds,Artemisia,Hepato-protective
- چکیده:
- چکیده انگلیسی: Objective: Liver is an important organ that is exposed to many oxidant and carcinogenic agents, thus antioxidant compounds are beneficial for liver health. Artemisia contains flavonoid compounds and anti-diabetic, antioxidant, and anti-inflammatory properties. Due to possessing terpene and sesquiterpene compounds, this plant has antioxidant properties. This study was done to investigate the effects of Artemisia plant extract on thioacetamide-induced hepatotoxicity in Wistar rats.
Materials and Methods: For induction of hepatotoxicity, 50 mg/kg thioacetamide was injected intraperitoneally (i.p).After extraction and purification, the hydroalcoholicextract was injected i.p. at 100, 200, and 300 mg/kg doses for 21 days together with thioacetamide at 50 mg/kg dose in the last 3 days. After blood sampling and separation of serum, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin, and total protein concentrations were measured.
Results: Significant decreases in aminotransferase and alkaline phosphatase activities and significant increases in the concentration of albumin and total protein in groups treated with the extract compared with thioacetamide-treated group were observed (p<0.05).
Conclusion: The results indicate that protective effects of Artemisia extract against the thioacetamide-induced hepatotoxicity may be due to its ability to block the bioactivation of thioacetamide, primarily by inhibiting the activity of Cyp450 and free radicals. Artemisia possesses quercetin. Studies have demonstrated that quercetin inhibits lipid peroxidation and as an antioxidant can inhibit lipid peroxidation.- انتشار مقاله: 23-11-1391
- نویسندگان: Azam Rezaei,Shahnaz ShekarForoush,Saeed Changizi Ashtiyani,Hydar Aqababa,Ali Zarei,Maryam Azizi,Hasan Yarmahmodi
- مشاهده