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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: cancer,Pakistan,incidence,Registry,Karachi
- چکیده:
- چکیده انگلیسی: Objectives: To estimate the cancer incidence by age group and gender for the population of Karachi Division by analyzing the Karachi Cancer Registry data of 2017-19. Settings: The population of Karachi division is 16.1 million according to national census 2017. ‘Karachi Cancer Registry’ which is a part of ‘National Cancer Registry’ is collecting data from eight major hospitals in Karachi since 2017. For outcome measures, cancer counts and the age standardized incidence rates (ASIR) per 100,000 population were computed for age groups (0–14, 15–19 and ≥20 years), in both genders and all cancer site/type. Methods: The population denominators were based on the population of Karachi division estimated at 16.1 million in the population census, 2017. Counts and age-standardized incidence rates (ASIR) were calculated for each of the three age categories. Results: From Jan 2017 till Dec 2019 a total of 33,309 malignant cases were recorded in KCR database comprising 17,490 (52.5%) females and 15,819 (47.5%) males. ASIRs in age groups 0-14, 15-19 and ≥ 20 years, among female were 11.5, 2.4 and 223.6 and in males were 17.6, 3.2 and 216.7 respectively. The commonest diagnosis in children, adolescent and adults were (1) among females: children; bone (3.12), leukemia (2.09) brain/CNS (1.26); in adolescents: bone (0.78), brain/CNS (0.27), connective and soft tissue (0.11), in adults: breast cancer (76.07), oral cancer (16.68) and ovary (10.89) respectively, and (2) among males: children; bone (4.56), leukemia (2.79) and brain/CNS (1.88); in adolescent; bone (1.19), brain/CNS (0.31) and leukemia (0.21) and in adults: oral cancer (42.83), liver (16.10) and bone (13.37) respectively. Conclusion: Oral Cancer, a largely preventable cancer is the leading cancer in Karachi adult males while in female adults Breast Cancer is the leading cancer followed by Oral Cancer. In children and adolescents Bone, Leukemia and Brain/CNS malignancies are most common.
- انتشار مقاله: 24-03-1399
- نویسندگان: Shahid Pervez,Adnan A Jabbar,Ghulam Haider,Shamvil Ashraf,Muhammad Asif Qureshi,Fouzia Lateef,Imtiaz Bashir,Manzoor Zaidi,Mohammad Khurshid,Mohammad Saeed Quraishy,Tariq Siddiqi,Uzma Rizwan,Muhammad Arif Nadeem Saqib,Muhammad A Memon,Ejaz Alam,Huma Qureshi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Lung adenocarcinoma,IHC,ALK,fish
- چکیده:
- چکیده انگلیسی: Anaplastic lymphoma kinase (ALK) gene can be oncogenic either by forming fusion with other genes, amplification
of the gene or by having mutations. ALK rearrangement can either be detected by standard “fluorescence in situ
hybridization (FISH)” or “immunohistochemistry (IHC)”. Objective of this study was to record the prevalence of
ALK rearrangement in adenocarcinoma of Primary Lung origin and compare it with ALK-IHC staining. Data of
64 patients of lung adenocarcinoma from 2015-2017 was analyzed. All of the FFPE biopsies were tested for EGFR
(qPCR) followed by ALK rearrangement (by FISH and IHC) on EGFR negative samples. Out of 64 samples, 21.8%
(14) showed EGFR mutations and 14% (7/50) were positive for ALK rearrangement when checked by FISH. In IHC
testing for ALK (FISH positive) 8% (4/50) showed positivity. In conclusion ALK-FISH positive cases are higher than
other studies likely due to the relatively small sample size. FISH testing was found to be more sensitive than IHC; one
reason may be the low level of ALK. Our study warrants that currently FISH remains the gold standard for screening
of ALK gene rearrangements.- انتشار مقاله: 20-09-1396
- نویسندگان: Samar Moattar,Namrah Anwar,Tariq Moatter,Shahid Pervez
- مشاهده