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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی: cancer,Bone,sCD30,Sarcoma,sCD40L
- چکیده:
- چکیده انگلیسی: Background: Primary malignant bone tumors are heterogeneous groups of neoplasms, which affect mainly children and adolescents. The most common types are Osteosarcoma, Ewing sarcoma and chondrosarcoma. Elevation of sCD30 and sCD40L has been observed in lymphoma, leukemia and autoimmune disorders.
Objective: To evaluate serum concentrations of sCD30 and sCD40L in patients with primary malignant bone tumors.
Method: Fifty-four cases (31 Osteosarcomas, 14 Ewing sarcomas, and 9 Chondrosarcomas) and 54 healthy controls enrolled in this study. Cases with the history of prior treatment (surgery, chemotherapy and radiotherapy) were excluded from the study. Serum levels of sCD30 and sCD40L were detected by an enzyme linked immunosorbent assay (ELISA).
Results: Mean serum concentration of sCD30 in Ewing sarcoma was significantly higher than that of the control groups (p=0.007), but mean serum concentrations of sCD30 in osteosarcoma and chondrosarcoma groups were not significantly different, compared to the controls (p=0.41 and p=0.11, respectively). Mean serum concentrations of sCD40L in osteosarcoma, Ewing sarcoma and chondrosarcoma groups were significantly higher than that of the control group (p<0.0001). In addition, the mean serum level of sCD40L in chondrosarcoma patients was higher than that of both Ewing sarcoma and osteosarcoma groups (p<0.001).
Conclusion: sCD30 and sCD40L increase in primary bone tumors; however the significant of these findings for diagnosis or prognosis of these tumors needs further investigation.- انتشار مقاله: 15-05-1395
- نویسندگان: Saeed Solooki,Arash Khozaei,Seyedeh Azra Shamsdin,Mohammad Jafar Emami,Farnaz Khademolhosseini
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Glioma,Meningioma,Angiogenic factors,Inflammatory cytokine
- چکیده:
- چکیده انگلیسی: Background: Meningioma and glioma are common central nervous system tumors. Hypoxic tumor cells secrete angiogenic cytokines, such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) that stimulate neovascular formation and inflammatory cytokine, such as TNF-α and IL-1β. We measured these serum levels in patients with glial cell tumors and meningioma. Materials and Methods: This was a case-control study in 2014-2015 on patients diagnosed with meningioma/glioma. All demographic and clinical data were registered. The tumor volume and intraoperative bleeding were recorded. Serum levels of VEGF, PDGF, FGF, TNF-α and IL-1β were measured by ELISA methods. Results: Ninety-six patients were enrolled in this study, 32 in each group. Patients VEGF level with cranial tumor, glioma/meningioma had increased. VEGF level was highest among grade IV tumors, larger tumors, and in glioblastoma multiform. There was an upsurge in VEGF serum level as glioma grade increased. The highest VEGF levels were seen in parasagittal meningioma. In contrast to VEGF, PDGF was slightly elevated in glial cell tumors, which was significantly elevated in meningioma. Higher PDGF correlated with increased intraoperative bleeding, especially in meningioma cases. Oligodendroglial tumors expressed higher PDGF levels in contrast to other glial tumors. FGF level was not statistically significant. TNF-α and IL-1β expressions were significantly higher in the meningioma and glioma group in comparison to control group. Conclusion: We found increased VEGF and PDGF serum levels in CNS patient’s tumor. A different role for PDGF was found in the pathogenesis of neovascularization of meningioma, as well as oligodendroglioma. No significant result was found for FGF. TNF-α and IL-1β can serve as key prognostic biomarker in high-grade glioma and meningioma patients.
- انتشار مقاله: 19-04-1397
- نویسندگان: Seyedeh Azra Shamsdin,Ali Mehrafshan,Seyed Mohammad Rakei,Davood Mehrabani
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Key words: Colon cancer,PD.1,ICOS,Polymorphism
- چکیده:
- چکیده انگلیسی: Background: Positive and negative co-stimulatory molecules are important factors determining the outcome
of immune responses to the presence of tumors. Since co-stimulatory molecule expression may be affected by gene
polymorphisms, we aimed to investigate associations between variants of PD.1 and ICOS and susceptibility to colon
cancer. Material and methods: ICOS (-693A/G), ICOS (+1720C/T) and PD.1 (-538G/A) gene polymorphisms were
evaluated by the PCR-RFLP method in 76 colon cancer patients and 73 healthy controls. Results: The frequencies
of the GG genotype and the G allele at position -693 of the ICOS gene were significantly higher in the patient group
(P=0.014 and p=0.0002), while the AA genotype was significantly more common in controls (P=0.0016). At position
-538 of PD.1, GG genotype and G allele frequencies were higher in the patient group (PAA and also AG genotypes significantly predominated in controls (Pand alleles of ICOS at position +1720. Frequencies of GCG and GTG haplotypes were higher in patients compared
to those of controls (P=0.016 and P<0.0001), while, frequencies of GTA, ATA and ATG haplotypes were higher in
controls (P=0.0017, Ppatients compared to controls (P=0.0147 and P=0.0071). Conclusion: Our study clarified that PD.1 (-538G/A) and
ICOS (-693A/G) gene polymorphisms can be considered as genetic risk factors for the development of colon cancer
among Iranian patients.- انتشار مقاله: 17-03-1396
- نویسندگان: Seyedeh Azra Shamsdin,Mohammad Hossein Karimi,Seyed Vahid Hosseini,Bita Geramizadeh,Mohamad Reza Fattahi,Davood Mehrabani,Ali Moravej
- مشاهده