در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Severity,Vascular Endothelial Growth Factor (VEGF),COPD,Exacerbation
- چکیده:
- چکیده انگلیسی: Background: Chronic Obstructive Pulmonary Disease (COPD) is a chronic lung disease characterized by progressive and irreversible obstruction of the airways of the lungs. Different studies have emphasized on the role of Vascular Endothelial Growth Factor (VEGF) in COPD patients. The aim of this study was to investigate the relationship of this factor with disease severity and the number of exacerbations in COPD patients. Methods: This study is a Cross-sectional study on patients with chronic obstructive pulmonary disease referred to Besat clinic in Kerman in 2013-2014. After performing spirometery and confirming COPD diagnosis by a pulmonologist and obtaining consent form patients, blood samples were taken and level of VEGF was measured by ELISA method. Results: Mean serum level of VEGF in patients was 160±156.6 µg/ml. More disease severity was associated with higher level of VEGF, but this association was not significant. No relationship was found between the number of exacerbations and VEGF level. Conclusion:The results of our study showed that serum levels of VEGF increases in COPD patients, but there is not a significant correlation between serum levels of VEGF and the severity of the disease and the number of exacerbations.
- انتشار مقاله: 02-06-1395
- نویسندگان: Seyed-Mehdi Hashemi-Bajgani,Mitra Samareh Fekri,Hadi Zeydabadi,Mohammad Rahmatian,Arian Amirkhosravi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,genetic polymorphisms,Smad7,MIR-375
- چکیده:
- چکیده انگلیسی: Background: Today, the role of microRNAs in the pathogenesis of breast cancer has been established. Genetic mutations play a significant role in determining the risk factors of cancer. The polymorphism of these two genes can alter their expression. This study has been performed to investigate the relationship between polymorphisms of rs6715345 of miR-375 gene and rs4939827 of the SMAD7 gene and development of breast cancer in a population in southeastern Iran. Methods: This case-control study was performed on the blood sample of 205 patients with breast cancer and 200 healthy individuals for investigating the rs34917480 and rs4939827 polymorphisms using the PCR-RFLP method. The data were analyzed by t-test, χ2, and logistic regression. The SPSS v18.0 used for data analysis. Results: The findings of this study indicated that the risk of developing breast cancer does not have a significant relationship with rs6715345 polymorphism of miR-375 gene (p<0.1). However, the rs4939827 polymorphism of the SMAD7 gene was significantly linked to the risk of developing breast cancer in the southeastern population in Iran (p>0.01). Conclusion: The results suggest that the rs4939827 polymorphism of the SMAD7 gene can lead to an increased risk of incidence of breast cancer in the southeastern population in Iran.
- انتشار مقاله: 21-04-1399
- نویسندگان: Seyed-Mehdi Hashemi,Mohammad Hashemi,Gholamreza Bahari,Afsaneh Khaledi,Hoseinali Danesh,Abolghasem Allahyari
- مشاهده