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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Evidence Based Care Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: Quality of Life,Obesity,Psychometric,Checklist,Morbid,Review of literature
- چکیده:
- چکیده انگلیسی: Background: Since studies have demonstrated that morbid obesity can exponentially impair quality of life, the measurement of quality of life is paramount to monitoring the effects of treatment and influences the development of clinical pathways, service provision, healthcare expenditures, and public health policy. Accordingly, clinicians, researchers, and policy makers must rely on valid instruments.
Aim: This study aimed to review and critique the psychometric properties of some specific tools by COSMIN checklist and their application among morbidly obese individuals.
Method: We searched PubMed, Web of Science, PsycINFO, Ovid, Elsevier, and ScienceDirect by using the keywords related to the Quality of Life Questionnaire, namely “morbid obesity”, “tool”, and “scale”, to retrieve articles published during 1989-2017. Then, the psychometric properties of the selected tools were assessed using the COSMIN checklist.
Results: Most of the tools had not reported complete and desirable psychometrics properties. Demonstration of responsiveness from independent randomized controlled trials was not available in two of the eight questionnaires. These tools also did not report proper definition of interpretability. However, the data obtained by COSMIN checklist showed that Laval questionnaire is a proper scale for measuring quality of life in obese individuals, which can be recommended to researchers.
Implications for Practice: Although Laval questionnaire was found a proper tool for measuring the
quality of life among morbid obese patients, developing an instrument suitable for different societies with varied cultural and social characteristics is suggested because socio-cultural factors can influence the quality of life.- انتشار مقاله: 20-06-1396
- نویسندگان: Negar Yazdani,Farkhondeh Sharif,Nasrin Elahi,Abbas Ebadi,Seyed Vahid Hosseini
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Key words: Colon cancer,PD.1,ICOS,Polymorphism
- چکیده:
- چکیده انگلیسی: Background: Positive and negative co-stimulatory molecules are important factors determining the outcome
of immune responses to the presence of tumors. Since co-stimulatory molecule expression may be affected by gene
polymorphisms, we aimed to investigate associations between variants of PD.1 and ICOS and susceptibility to colon
cancer. Material and methods: ICOS (-693A/G), ICOS (+1720C/T) and PD.1 (-538G/A) gene polymorphisms were
evaluated by the PCR-RFLP method in 76 colon cancer patients and 73 healthy controls. Results: The frequencies
of the GG genotype and the G allele at position -693 of the ICOS gene were significantly higher in the patient group
(P=0.014 and p=0.0002), while the AA genotype was significantly more common in controls (P=0.0016). At position
-538 of PD.1, GG genotype and G allele frequencies were higher in the patient group (PAA and also AG genotypes significantly predominated in controls (Pand alleles of ICOS at position +1720. Frequencies of GCG and GTG haplotypes were higher in patients compared
to those of controls (P=0.016 and P<0.0001), while, frequencies of GTA, ATA and ATG haplotypes were higher in
controls (P=0.0017, Ppatients compared to controls (P=0.0147 and P=0.0071). Conclusion: Our study clarified that PD.1 (-538G/A) and
ICOS (-693A/G) gene polymorphisms can be considered as genetic risk factors for the development of colon cancer
among Iranian patients.- انتشار مقاله: 17-03-1396
- نویسندگان: Seyedeh Azra Shamsdin,Mohammad Hossein Karimi,Seyed Vahid Hosseini,Bita Geramizadeh,Mohamad Reza Fattahi,Davood Mehrabani,Ali Moravej
- مشاهده
- جایگاه : پژوهشی
- مجله: Annals of Colorectal Research
- نوع مقاله: Journal Article
- کلمات کلیدی: cancer,Colorectal Surgery,Laparoscopy,Rectum
- چکیده:
- چکیده انگلیسی: Background: Transanal Total Mesorectal Excision (TaTME) presented in recent years as a novel technique to achieve better outcome in circumferential margin (CRM) and distal margin (DRM) in lower rectal cancer operation. The current study aimed to assess the perioperative and pathological characteristics of TaTME in comparison with laparoscopic total mesorectal excision (LaTME) in patients with mid- and low-rectal cancer.
Methods: From January 2016 to December 2018, we enrolled all consecutive patients with rectal cancer, who underwent TaTME and LaTME. Primary endpoints like circumferential rectal margin (CRM) status, distal rectal margin (DRM) status, and pathological outcomes, as well as secondary endpoints including perioperative outcomes (total blood loss, duration of hospitalization, anastomosis leakage, as well as 30-day mortality) were evaluated and compared statistically (α=0.05).
Results: 11 patients with distal rectal adenocarcinoma which was biopsy-proven, underwent TaTME, and 19 patients operated on using LaTME. Both groups were similar in the baseline characteristics. Also, the perioperative outcomes were similar in both groups. Regarding pathological outcomes, no patients with CRM Conclusion: TaTME is a reasonable procedure in patients with low rectal cancer. But no remarkable superiority was observed in this method compared to laparoscopy with respect to the pathological outcomes.- انتشار مقاله: 08-09-1399
- نویسندگان: Seyed Vahid Hosseini,Leila Ghahramani,Seyed Farhad Tayari,Alireza Izadi,Razieh Sadat Mousavi-Roknabadi,Zahra Beizavi
- مشاهده
- جایگاه : پژوهشی
- مجله: Annals of Colorectal Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Fecal incontinence,Episiotomy,Anal
- چکیده:
- چکیده انگلیسی: Background: Fecal incontinence is an embarrassing problem and decreases the woman’s quality of life. The literature has shown that women with obstetric trauma especially by episiotomy had damaged anal sphincter (Internal and External). We aimed to find the role of episiotomy in the fecal incontinence in women after delivery.
Methods: In this study, 71 females with previous vaginal deliveries were investigated by endoanal ultrasonography. The degree of FI was measured using the incontinence score of Wexner. The number of episiotomies was measured for each patient.
Results: The mean Wexner score was 9.0±0.7 in the incontinent patients. The mean of normal vaginal delivery was 3.48±0.3 and 33.8% of the patients whom had a history of hemorrhoidectomy. Of patients, 70% had undergone one or more prior episiotomies during their deliveries.
Conclusion: Episiotomy could be one of the risk factors in fecal incontinence but we did not find any significant difference in Wexner score between patients with or without episiotomy. Endoanal sonography seems an effective tool to evaluate and prediction of anal injury during episiotomy in some critical cases.- انتشار مقاله: 09-04-1399
- نویسندگان: Hajar Khazraei,Seyed Vahid Hosseini,Mozhdeh Zamani,Ahmed Mohammed Ali Hussein Al-Hurry,Masoumeh Rahimi,Leila Ghahramani,Fahimeh Haji Hosseini
- مشاهده
- جایگاه : پژوهشی
- مجله: Annals of Colorectal Research
- نوع مقاله: Journal Article
- کلمات کلیدی: cancer,Stress,Endoplasmic reticulum,UPR,Wnt
- چکیده:
- چکیده انگلیسی: Abstract:
1. Context
Endoplasmic reticulum stress (ER stess) is associated with endoplasmic reticulum perturbation homeostasis. Prolonged ER stress conditions may induce cell death. Unfolded protein response (UPR) attempts to restore normal cell conditions.
2. Evidence Acquisition
There now exists an emergent body of evidence identifying the WNT signaling network as a regulator of cancer cell metabolism. Given that existing findings show that the WNT pathway and ER stress regulates changes in metabolic activities of cancer cells suggesting these signaling pathways represent critical nodes in the regulation of central metabolism in tumors.
3. Results
Findings suggest that the molecular cross-talks between hypoxic ER stress, Wnt/βcatenin signaling, may represent an important mechanism that enables some tumor subtypes to survival and grow in hypoxic conditions.
4. Conclusions
The present article disuses differential effects of the activation of the three arms of UPR, namely endoplasmic reticulum kinase (PERK), activation transcription factor -6 (ATF-6), and inositol –requiring enzyme (IRE-1) on cancer. This review also highlights regulators and downstream effectors of Wnt cascade and addresses the increasingly apparent crosstalk of Wnt with other tumorigenic signaling pathways.- انتشار مقاله: 27-11-1398
- نویسندگان: Morvarid Siri,Seyed Vahid Hosseini,Sanaz Dastghaib,Pooneh Mokarram
- مشاهده
- جایگاه : پژوهشی
- مجله: Annals of Colorectal Research
- نوع مقاله: Journal Article
- کلمات کلیدی: essential oil,Zataria multiflora,Hematological parameters,Biochemical parameters,Clinical study
- چکیده:
- چکیده انگلیسی: Abstract
Background: Zataria multiflora Boiss is a well-known medicinal plant and its’ essential oil (EO) is traditionally used for treatment of respiratory and digestive disorders and/or bacterial, viral, fungal, and parasitic infections.
Objective: This study was undertaken to evaluate the effect of long-term consumption of Z. multiflora EO on hematological and biochemical parameters in patients infected with liver hydatid disease.
Materials and Methods: Fifteen patients were administered orally with Z. multiflora EO (60 mg daily) for six months. Hematological and biochemical analysis were performed on the blood samples of patients before the start of treatment and after completion of the treatment course. In hematological analysis, WBC, RBC, Hb, hematocrit, MCV, MCH, MCHC and platelets were measured. In biochemical analysis, FBS, BUN, creatinine, cholesterol, triglycerides, HDL, LDL, Na, K, Cl, AST, ALT, and ALK were assessed.
Results: No apparent changes were observed in the values of hematological parameters of the patients after treatment. No significant changes also occurred in the values of FBS, BUN, creatinine, cholesterol, triglycerides, HDL, LDL, Na, and K. The mean values of AST, ALT and ALK enzymes decreased significantly after treatment (P ˂ 0.05). No adverse clinical event was noticed in the patients during the course of study.
Conclusions: Long-term consumption of Z. multiflora EO induced no adverse effect on the hematological and biochemical parameters of patients infected with liver hydatid disease. Since Z. multiflora EO reduced the level of liver transaminases (AST, ALT and ALK), this herbal product may be considered as a hepatoprotective agent in human beings.- انتشار مقاله: 07-11-1398
- نویسندگان: Arash Jafari,Mohammad Moazeni,Seyed Vahid Hosseini,Hajar Khazraei,Samane Nematolahi,Seyed Mohammad Kazem Tadayon
- مشاهده
- جایگاه : پژوهشی
- مجله: Annals of Colorectal Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Colorectal cancer,biobank,biorepository,biobank network
- چکیده:
- چکیده انگلیسی: Background: Cancer research is highly dependent of large amount of data and high quality samples which can be provided by networks to enable large-scale multi-center research projects. Biologic materials, such as blood, tissue samples, DNA, body fluids and the related data obtained in cohorts and clinical trials are valuable sources for research which should be managed by policies and standard operating procedures as biorepositories or biobanks.
Methods and evidence acquisition: The authors investigated and summarized pubmed database articles using biobanks and describing the policies.
Conclusion: biobanking as a young discipline in different countries needs new technologies, standards and harmonization. In this review article, we have an overview on biorepository, cancer biobanking and the emerging registry in Iran.
Background: Cancer research is highly dependent of large amount of data and high quality samples which can be provided by networks to enable large-scale multi-center research projects. Biologic materials, such as blood, tissue samples, DNA, body fluids and the related data obtained in cohorts and clinical trials are valuable sources for research which should be managed by policies and standard operating procedures as biorepositories or biobanks.
Methods and evidence acquisition: The authors investigated and summarized pubmed database articles using biobanks and describing the policies.
Conclusion: biobanking as a young discipline in different countries needs new technologies, standards and harmonization. In this review article, we have an overview on biorepository, cancer biobanking and the emerging registry in Iran.- انتشار مقاله: 30-10-1398
- نویسندگان: Shima Fakher,Seyed Vahid Hosseini,Mozhdeh Zamani,Leila Ghahramani,Pooneh Mokaram Mokaram
- مشاهده
- جایگاه : پژوهشی
- مجله: Annals of Colorectal Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Disease free survival,Rectal Cancer,Adjuvant chemoradiation,Overall Survival
- چکیده:
- چکیده انگلیسی: Abstract
Background: Colorectal cancer causes many deaths worldwide and rectal cancer includes one-third of them. Surgical mesorectal excision along with preoperative neoadjuvant chemoradiotherapy is known as the standard treatment for rectal cancer. However, inaccurate preoperative staging is a main concern which leads to large number of patients not being treated with neoadjuvant therapy. Selection of the best treatment approach for these patients is controversial. Although significant better survival was observed is patients who received postoperative adjuvant chemoradiation compared with patients who treated with surgery alone, other studies did not find such results. Due to these contradictory results, this study was designed to further evaluate the survival outcomes in rectal cancer patients who received adjuvant chemoradiotherapy without neoadjuvant therapy. Methods: Totally 197 rectal cancer patients who received adjuvant chemoradiation were included in this study. The demographic and clinico-pathological characteristics of the patients were evaluated by statistical analysis. Results: Based on the univariate cox regression, poor disease free survival (DFS) was significantly associated with male sex and T3 stage. Poor overall survival (OS) was also associated with stage II/III, T3/T4, NI/NII, grade II/III, positive node number (> 3), perineural invasion, lymphovascular invasion, and margin involvement. According to the multivariate cox regression, independent predictive factors for DFS were T3 andT4 stage, and for OS were also T3/ T4 stage, grade II/ III and lymphovascular invasion. Conclusions: Taken together, obtained results indicated that combined adjuvant chemoradiation contributes to improve survival outcomes in the rectal cancer patients who did not received neoadjuvant therapy.- انتشار مقاله: 06-09-1398
- نویسندگان: Ahmad Izadpanah,Seyed Vahid Hosseini,Maytham Hameed Al-Qanbar,Mozhdeh Zamani,Behnam Kadkhodaei
- مشاهده
- جایگاه : پژوهشی
- مجله: Annals of Colorectal Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Single Nucleotide Polymorphism,Colorectal cancer,Iranian population
- چکیده:
- چکیده انگلیسی: Context: The incidence of colorectal cancer has significantly increased in Iran during the last decade. Accumulating evidence suggests
that there is a significant correlation between genetic variations such as polymorphisms and colorectal cancer. Therefore,
identification of critical polymorphisms related to colorectal cancer can contribute to find individuals at high risk of CRC.
Evidence Acquisition: The focus of this review was on published articles in English about the association between different single
nucleotide polymorphisms and colorectal cancer in the Iranian population. Evidences were gathered by searching online medical
databases including Google scholar, Pubmed, Scopus and Science Direct.
Conclusions: Various single nucleotide polymorphisms of critical genes indicated significant association with colorectal cancer in
the Iranian population. New polymorphism markers for high risk individuals have been recognized through further investigations
to reduce the incidence and mortality of colorectal cancer.
- انتشار مقاله: 02-10-1399
- نویسندگان: Mozhdeh Zamani,Seyed Vahid Hosseini,Pooneh Mokarram
- مشاهده
- جایگاه : پژوهشی
- مجله: Annals of Colorectal Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Therapeutics,Rectal Neoplasms,Colorectal Surgery,Microsurgery,Endoscopy
- چکیده:
- چکیده انگلیسی: conditions. Big deal of this procedure is avoiding of open abdominal surgeries or better exposure in transanal approches.
Objectives: The purpose of this study was to present a single institutional experience in Shiraz, Iran regarding the application of Transanal Endoscopic Microsurgery (TEM). To our knowledge this is the first report from the Middle East.
Patients and Methods: Between 2009 and 2012, thirty patients underwent TEM in our center. We assessed complications and recurrence rate. Patients with fewer than six months of follow-up were excluded.
Results: Patients included 17 men and 13 women with a mean age of 44.4 years (ranged 17-80). The mean tumor distance from the anal verge was 9.8 cm. One patient with adenomatous polyp experienced recurrence 14 months postoperatively. Regarding procedure-related complications, one case developed hemorrhage and another case fever and infection in the site of operation. Two patients experienced incontinence for about 3 weeks after TEM surgery.
Conclusions: Considering the cultural and religious context of the Middle East, we recommend TEM procedure in specialized centers in this region of the world.- انتشار مقاله: 26-12-1392
- نویسندگان: Seyed Vahid Hosseini Hosseini,Reza Roshanravan,Salar Rahimikazerooni,Mastoureh Mohammadipour,Ali Saberi,Hossein Shabahang,Ali Reza Safarpour,Leila Ghahramani
- مشاهده