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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Patient Safety & Quality Improvement
- نوع مقاله: Journal Article
- کلمات کلیدی: Differentiated thyroid cancer,whole body I131 scan,radio-iodine
- چکیده:
- چکیده انگلیسی: Introduction: Finding optimum time of post ablation whole body iodine scan in patients with differentiated thyroid cancer(DTC) treated with I-131.
Material and Methods: 20 patients with DTC, who were treated with I131 underwent post ablation whole body iodine scan (WBIS) in days 4, 7 and 9 after treatment. A dual head gamma camera (e-cam, Siemens) equipped with high energy parallel hole collimator was used for imaging. The images were acquired with 7cm/min and stored in a 1024 ×256 matrix.
Results: 3 Patients had negative WBIS in all three sets of imaging and 17 patients had postsurgical thyroid remnants on all 3 scans. On days 4 and 7 we detected 11 patients with cervical lymph node metastases while on day 9 only 9 patients showed cervical lymph node metastases.(P=0.135)
On all 3 sets of images, we encountered 4 patients with mediastinal lymph node metastases and 1 patient with bone metastasis. In addition, all 3 sets of images detected lung metastases in three patients. The total number of affected foci did not have any statistical differences in whole body scan of day 4, 7 and 9. (P = 0.083)
Conclusion: According to the radiation safety hazards for staff and technicians of nuclear medicine department and lack of difference in scan findings between 4 and 7 days after RAI, scanning the DTC patients in the day 7 after RAI administration , is more practicable, with less probability of missing the sites of involvement. Performing whole body iodine scans after 1 week is not recommended.- انتشار مقاله: 19-10-1397
- نویسندگان: Kamran Aryana,Mohammad Ramezani,Seyed Rasoul Zakavi,Atena Aghaee
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Physics
- نوع مقاله: Journal Article
- کلمات کلیدی: Monte Carlo simulation,Phantom SPECT Imaging System,SIMIND Program
- چکیده:
- چکیده انگلیسی: Introduction: In Single Photon Emission Computed Tomography (SPECT), the projection data used for image reconstruction are distorted by several factors, including attenuation and scattering of gamma rays, collimator structure, data acquisition method, organ motion, and washout of radiopharmaceuticals. All these make reconstruction of a quantitative SPECT image very difficult. Simulation of a SPECT system is a convenient method to assess the impact of these factors on the image quality.
Materials and Methods: The SIMIND Monte Carlo program was employed to simulate a Siemens E.CAM SPECT system. Verification of the simulation was performed by comparing the performance parameters of the system. The verified system was used for SPECT simulations of homogenous and inhomogeneous voxelized phantoms in conjugation with hardware modifications. The resulting data were compared with those obtained from the simulated system without any modifications. Image quality was assessed by comparing the Structural SIMularity index (SSIM), contrast, and resolution of images.
Results: The energy spectra acquired from both simulated and real SPECT systems demonstrated similar energy peak regions. The resulting full-widths-at-half-maximums were 13.92 keV for the simulation and 13.58 keV for experimental data, corresponding to energy resolutions of 9.95% and 9.61%, and with calculated sensitivities of 85.39 and 85.11 cps/MBq, respectively. Better performance parameters were obtained with a hardware-modified system constructed using a 0.944 cm thickness NaI(Tl) crystal covered by a layer of 0.24 cm aluminum, a slat of 4.5 cm Pyrex as a backscattering medium, and a parallel hole collimator of Pb-Sb alloy with 2.405 cm thickness.
Conclusion: The modeling of a Siemens E.CAM SPECT system was performed with the SIMIND Monte Carlo code. Results obtained with the code are in good agreement with experimental results. The findings demonstrate that the proposed hardware modifications in the system appear to be suitable for further improvement of the performance parameters of the system, indicating that future investigations can be conducted on using the system for supplementary studies on image improvement in the field of nuclear medicine.- انتشار مقاله: 10-12-1388
- نویسندگان: Mohammad Taghi Bahreyni Toossi,Jalil Pirayesh Islamian,Mahdi Momennezhad,Seyed Rasoul Zakavi,Ramin Sadeghi,Lejonberg M
- مشاهده
- جایگاه : پژوهشی
- مجله: Asia Oceania Journal of Nuclear Medicine and Biology
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Nuclear Medicine,Sanctions
- چکیده:
- چکیده انگلیسی: "It is not a wise choice!", this was the reaction of my father when I applied for nuclear medicine residency program 26 years ago. The old retired officer continued that hi-tech nuclear medicine is dependent on multiple advanced sections that may not be easily available especially in the developing countries. Now he is not alive to see that political misconducts have added fuel to the fire.
Global shortage of Technetium-99m in recent years revealed the vulnerability of nuclear medicine and dependency of our clinical departments on the policies of the governments to support production of radiotracers (1). Although the mission of International Atomic Energy Agency (IAEA) is to "accelerate and enlarge the contribution of atomic energy to peace, health, and prosperity throughout the world", its application is highly affected by local governmental policies (2)
Recent unilateral withdrawal of USA from Iran nuclear deal (Joint Comprehensive Plan Of Action-JCPOA) followed by imposing economic, trade and financial sanctions against Iran, has deleterious effect on nuclear medicine either on supply of radiotracers or spare parts of nuclear medicine devices (3). Although medicine is apparently not included in the list of sanctions, secondary sanction, aviation and transport embargo as well as financial restrictions, made it extremely difficult for medical companies to be able to do any transaction. Payment for the drugs or instruments and shipment of the goods to and from Iran have turned to a lengthy, difficult and risky task. Nuclear medicine seems to be at particular risk due to its link with atomic energy agency.- انتشار مقاله: 25-09-1397
- نویسندگان: Seyed Rasoul Zakavi,Seyed Rasoul Zakavi,Seyed Rasoul Zakavi,Seyed Rasoul Zakavi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asia Oceania Journal of Nuclear Medicine and Biology
- نوع مقاله: Journal Article
- کلمات کلیدی: Tablet splitting,Differentiated thyroid cancer, TSH, Levothyroxine, suppressive therapy
- چکیده:
- چکیده انگلیسی: Objective(s): TSH suppression by Levothyroxine consumption is a mainstay of thyroid cancer treatment. Tablet-splitting is a worldwide approach in dose adjustment in patients. However, it is highly recommended to evaluate the validity of tablet splitting for each distinctive drug by clinical trials before routinely using tablet halves in clinical practice. In this study we compared the effect of 150 μg dose of Levothyroxine by use of a100 and a 50 μg tablets or one and half 100 μg tablets in Differentiated thyroid cancer (DTC) patients.
Methods: One hundred DTC patients treated with one and half 100 μg Levothyroxine tablets were randomly divided into two groups. The first group continued taking medication as before and the second group received the same daily dose by taking one 100 and one 50 microgram Levothyroxine tablets. The mean changes in TSH and T3 levels and patients weight were compared between the groups.
Results: 91 patients completed the study. Levothyroxine consumption pattern, age, gender distribution, weight and TSH levels were comparable between groups at the beginning of the study. The mean change of body weights, serum levels of T3 and TSH showed no significant difference between groups in different time points during the study (P>0.05).
Conclusion: This study showed similar efficacy of tablet splitting and two tablets administration for Levothyroxine; however, patients preferred two tablets at the end of the study. It can be concluded that tablet splitting can be used as an alternative way when the 50 μg tablet is not available.- انتشار مقاله: 18-07-1396
- نویسندگان: Ramin Ashrafpour,Narjess Ayati,Ramin Sadeghi,Samira Zare Namdar,Nayyereh Ayati,Somaye Ghahremani,Seyed Rasoul Zakavi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asia Oceania Journal of Nuclear Medicine and Biology
- نوع مقاله: Journal Article
- کلمات کلیدی: AOJNMB,Award,Reviewer,Contributor
- چکیده:
- چکیده انگلیسی: AOJNMB is striving for excellence. Our journal is publishing its 4th volume of publication and we are delighted to observe on time publication of this journal with important scientific articles. On November 2015, 11th Asia Oceania Congress of Nuclear Medicine & Biology (AOCNMB) was held in Jeju International Convention Center (JICC) in Korea with hundreds of participants and the abstracts of the meeting were published as a supplement issue of the AOJNMB (1). The 11th AOCNMB meeting was a great opportunity for me to thank the best contributors of the AOJNMB in the last three years. Actually, AOJNMB awarded three contributors for their invaluable effort in years 2013-2015. Prof. Seigo Kinuya was awarded as our “Best Associate Editor” for the highest number of successful editorship, Prof.Henry Bom as “Top Contributor” with the highest number of reviewed articles and Prof.Jerry Obaldo as the “Best Reviewer” for his rapid, critical and instructive reviews.
- انتشار مقاله: 01-10-1394
- نویسندگان: Seyed Rasoul Zakavi,Seyed Rasoul Zakavi,Seyed Rasoul Zakavi,Seyed Rasoul Zakavi
- مشاهده