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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Biodistribution,Bone metastases,Radiopharmaceutical,DOTMP,Ytterbium-175
- چکیده:
- چکیده انگلیسی: Bone is the third most common site of metastatic disease. Bone pain is the major source of morbidity associated bone metastasis. Bone-seeking radiopharma- ceuticals have been applied for many years. The ability to simultaneously treat multiple sites of disease with a more probable therapeutic effect in earlier phases of metastatic disease is one of the advantages of radiopharmaceuticals. 175Yb is one of the radioisotopes with suitable properties for developing various nuclear medicine agents. Some of these proper properties include 4.2 days half-life, gamma-rays emitted, radionuclidic purity. Radiopharmaceuticals capable of targeting bone tumors generally use phosphonic acid functionality as the targeting moiety. In this direction cyclic tetraphosphonate, 1,4,7,10-tetraazacyclododecane-1,4,7,10 tetraaminomethylenephosphonate (DOTMP) has been labeled with 175YbCl3. Production, quality control and biodistribution studies of 175Yb-DOTMP were targeted in this study. 175Yb chloride with mean specific activity of 31 mCi/mg was obtained by thermal neutron flux (3×1013 n.cm-2.s-1) of a natural Yb2O3 sample (isotopic purity of 31.8% for 174Yb) in the Tehran Research Reactor (TRR). Radiolabeling was completed in one h by the addition of DOTMP at room temperature. The radiochemical purity was determined using ITLC and it was more than 98%. The results of biodistribution animal studies are excellent. It was rapidly taken up in the bone in 2 h after injection (ID/g%=3.92) and reminded after 4 d (ID/g%=3.91).
- انتشار مقاله: 15-09-1390
- نویسندگان: Laleh Safarzadeh,Mohammad Ghannadi-Maragheh,Akbar Anvari,Seyed Mahmoud Reza Aghamiri,Simindokht Shirvani-Arani,Ali Bahrami-Samani
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Physics
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Cobalt 60,Tangential Irradiation,3D Treatment Planning,6MV Photon Beam
- چکیده:
- چکیده انگلیسی: Introduction: Radiation therapy following breast conserving surgery is one of the most common procedures performed in any radiation oncology department. A tangential parallel-opposed pair is almost always the technique of choice for this purpose. This technique is often performed based on 3D treatment planning. The aim of this study was to compare 3D treatment planning for two different energies (Cobalt 60 versus 6 MV photon beams) in tangential irradiation of breast conserving radiotherapy. In this comparison, homogeneity of isodoses within the breast volume and dose received by lungs were considered.
Materials and Methods: In this study, twenty patients with breast cancer treated with conservative surgery were included. A CT scan was performed on selected patients. Three-dimensional treatment planning with 6 MV photon beams was carried out for patients on the Eclipse 3D treatment planning system (TPS). The volumes receiving lower than 95% (Vol<95) (cold areas) and greater than 105% (Vol>105) (hot areas) of the reference dose, and the volume of lung receiving ≥30Gy (Vol≥30Gy) were derived from dose volume histograms (DVHs). Dose homogeneity index was calculated as: DHI = 100 – (Vol>105 + Vol<95). In the second stage, each patient was replanned with Cobalt 60 and the quantities of interest were obtained from the DVHs.
Results: Comparing 3D treatment planning by 6 MV and Cobalt 60 photons, cold areas were reduced (p<0.001), hot areas were decreased (p<0.7), DHI was improved (P<0.001) and Vol≥30Gy was reduced (P<0.017) with 6 MV photons.
Discussion and Conclusion: Our results indicate that treatment planning with Cobalt 60 causes more cold areas in the treated volume as compared with 6 MV photons. Cold areas within the target volume of the breast result in reduced tumor control probability. The plan can be optimized to limit dose to lung volume by using 6 MV photons. So lung fibrosis is more likely to occur with Cobalt 60. In addition, DHI was improved with 6 MV photon beams. Improvement of dose homogeneity can lead to higher tumor control probability and cosmetic results, and less skin and lung side effects. Hence, 3D treatment planning with 6 MV photon beams is a more suitable option for patients with breast cancer treated with conserving surgery- انتشار مقاله: 31-01-1390
- نویسندگان: Robab Anbiaee,Seyed Mahmoud Reza Aghamiri,Zahra Falahatpour
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Apoptosis,Esophageal carcinoma,Metformin,2-Deoxy-D-Glucose
- چکیده:
- چکیده انگلیسی: Background: Both mitochondrial dysfunction and aerobic glycolysis are signs of growing aggressive cancer. If altered metabolism of cancer cell is intended, using the glycolysis inhibitor (2-deoxyglucose (2DG)) would be a viable therapeutic method. The AMP-activated protein kinase (AMPK), as a metabolic sensor, could be activated with metformin and it can also launch a p53-dependent metabolic checkpoint and might inhibit cancer cell growth. Methods: After treatment with 5 mM metformin and/or 500 µM 2DG, the TE1, TE8, and TE11 cellular viability and apoptosis were assessed by MTT, TUNEL, and ELISA methods. The changes in p53 and Bcl-2 genes expression levels were examined using real-time PCR method. Data were analyzed by Kruskal-Wallis test using the SPSS 17.0 software. Results: Metformin and 2DG, alone and in combination, induced apoptosis in the cell lines. Real-time PCR revealed that metformin induced apoptosis in TE8 and TE11 cells by activating p53, down-regulating Bcl-2 expression. The induced apoptosis by 2DG raised by metformin and the combination modulated the expression of Bcl-2 protein in all cell lines and it was more effective in TE11 cell line. Conclusion: Metformin induced apoptosis in ESCC by down-regulating Bcl-2 expression, and up-regulating p53 and induced apoptosis increased by 2-deoxy-d-glucose. Thus, the combination therapy is an effective therapeutic strategy for esophageal squamous cell carcinoma.
- انتشار مقاله: 19-03-1396
- نویسندگان: Abbas Shafaee,Jalil Pirayesh Islamian,Davoud Zarei,Mohsen Mohammadi,Kazem Nejati-Koshki,Alireza Farajollahi,Seyed Mahmoud Reza Aghamiri,Mohammad Rahmati Yamchi,Behzad Baradaran,Mohammad Asghari Jafarabadi
- مشاهده