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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: liver disease,Cystic fibrosis,Diagnostic Methods
- چکیده:
- چکیده انگلیسی: Cystic fibrosis-associated liver disease (CFLD) is an important aspect of cystic fibrosis (CF), which manifests with various signs and symptoms. Lack of specific examinations for CFLD have made the diagnostic process of the disease time-consuming, and the disease is often identified after severe progress. Finding the associations between the outcomes of various clinical, biochemical, and sonography examinations could help specialists identify the disease in a timely manner. This review study aimed to determine the correlations between the outcomes of various diagnostic approaches based on the current literature. According to the literature, some studies have reported correlations between various diagnostic approaches, while other studies have reported no associations in this regard. This discrepancy could be due to the various manifestations associated with CF.
- انتشار مقاله: 15-11-1396
- نویسندگان: Hamid Reza Kianifar,Yalda Rezaei,Ali Khakshour,Hassan Karami,Maryam Khalesi,Seyed Ali Jafari,Mohammad Ali Kiani,Veda Vakili,Seyed Ali Alamdaran
- مشاهده
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: IGF-1,Cystic fibrosis,Human IGFBP3- protein
- چکیده:
- چکیده انگلیسی: Introduction: Cystic fibrosis is one of the most common autosomal recessive diseases that affects sweat glands and mucosa. CF is a hereditary disease with annual incidence of about 2500 new cases in United Kingdom. Insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 levels decrease in CF. The aim of this study was to assess the role of growth peptides in patients with CF.
Method: We searched PubMed, Google scholar, IranMedex, and Scientific Information Database (SID) in September 2012 to April 2014. We included clinical studies with available abstracts and full texts that were in English or Persian languages. Manual searching was conducted within the reference lists of articles. Two reviewers independently applied eligibility criteria, assessed quality, and extracted data.
Result: The earliest study was published in 1997 and the most recent one was in 2014. Study participants were adults in 3 studies (20%) and 12 studies (80%) were conducted in children. Patients with CF have lower levels of IGF-1 and there is a significant correlation between IGF-1 levels and growth index in patients with CF.
Conclusions: IGF-1 decreases in children with CF and might be the cause of poor growth and low body mass index in these children.- انتشار مقاله: 06-11-1393
- نویسندگان: Negar Khalighi,Rahim Vakili,Mohammad Ali Kiani,Seyed Ali Jafari,Hamid Reza Kianifar
- مشاهده
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: liver disease,Pentoxifylline,Hepatopulmonary syndrome
- چکیده:
- چکیده انگلیسی: Introduction: Hepatopulmonary syndrome (HPS) is known as a chronic liver disease associated with severe pulmonary deoxygenation due to intrapulmonary vascular vasodilation. Although liver transplantation is accepted as a main treatment of HPS, identifying effective drugs for recovery of HPS can be effective in postponing the transplantation and decreasing the mortality rate of patients before the transplantation. In this study we briefly reviewed the pathogenesis of HPS and also systematically reviewed the current pharmacological treatment of HPS.
Method: Pubmed, Scopus, and Google scholar were searched for the relevant English language clinical and experimental articles about the medications used in the treatment of HPS.
Results: A total of 38 articles were included in this study which mostly resulted in decreasing NOS expression, NO production, endothelin-1 activation, intrapulmonary angiogenesis and increasing oxygenation.
Conclusion: Various drugs have been proposed in treatment of HPS but more large controlled trial studies, is necessary to determine the exact efficacy of each drugs for HPS recovery.- انتشار مقاله: 16-11-1392
- نویسندگان: Leili Zarifmahmoudi,Maryam Khalesi,Ramin Sadeghi,Seyed Ali Jafari,Mohammad Ali Kiani,Hamidreza Kianifar
- مشاهده
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: liver disease,Pentoxifylline,Hepatopulmonary syndrome
- چکیده:
- چکیده انگلیسی: Introduction: Hepatopulmonary syndrome (HPS) is known as a chronic liver disease associated with severe pulmonary deoxygenation due to intrapulmonary vascular vasodilation. Although liver transplantation is accepted as a main treatment of HPS, identifying effective drugs for recovery of HPS can be effective in postponing the transplantation and decreasing the mortality rate of patients before the transplantation. In this study we briefly reviewed the pathogenesis of HPS and also systematically reviewed the current pharmacological treatment of HPS.
Method: Pubmed, Scopus, and Google scholar were searched for the relevant English language clinical and experimental articles about the medications used in the treatment of HPS.
Results: A total of 38 articles were included in this study which mostly resulted in decreasing NOS expression, NO production, endothelin-1 activation, intrapulmonary angiogenesis and increasing oxygenation.
Conclusion: Various drugs have been proposed in treatment of HPS but more large controlled trial studies, is necessary to determine the exact efficacy of each drugs for HPS recovery.- انتشار مقاله: 16-11-1392
- نویسندگان: Leili Zarifmahmoudi,Maryam Khalesi,Ramin Sadeghi,Seyed Ali Jafari,Mohammad Ali Kiani,Hamidreza Kianifar
- مشاهده
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: IGF-1,Cystic fibrosis,Human IGFBP3- protein
- چکیده:
- چکیده انگلیسی: Introduction: Cystic fibrosis is one of the most common autosomal recessive diseases that affects sweat glands and mucosa. CF is a hereditary disease with annual incidence of about 2500 new cases in United Kingdom. Insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 levels decrease in CF. The aim of this study was to assess the role of growth peptides in patients with CF.
Method: We searched PubMed, Google scholar, IranMedex, and Scientific Information Database (SID) in September 2012 to April 2014. We included clinical studies with available abstracts and full texts that were in English or Persian languages. Manual searching was conducted within the reference lists of articles. Two reviewers independently applied eligibility criteria, assessed quality, and extracted data.
Result: The earliest study was published in 1997 and the most recent one was in 2014. Study participants were adults in 3 studies (20%) and 12 studies (80%) were conducted in children. Patients with CF have lower levels of IGF-1 and there is a significant correlation between IGF-1 levels and growth index in patients with CF.
Conclusions: IGF-1 decreases in children with CF and might be the cause of poor growth and low body mass index in these children.- انتشار مقاله: 06-11-1393
- نویسندگان: Negar Khalighi,Rahim Vakili,Mohammad Ali Kiani,Seyed Ali Jafari,Hamid Reza Kianifar
- مشاهده
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: liver disease,Cystic fibrosis,Diagnostic Methods
- چکیده:
- چکیده انگلیسی: Cystic fibrosis-associated liver disease (CFLD) is an important aspect of cystic fibrosis (CF), which manifests with various signs and symptoms. Lack of specific examinations for CFLD have made the diagnostic process of the disease time-consuming, and the disease is often identified after severe progress. Finding the associations between the outcomes of various clinical, biochemical, and sonography examinations could help specialists identify the disease in a timely manner. This review study aimed to determine the correlations between the outcomes of various diagnostic approaches based on the current literature. According to the literature, some studies have reported correlations between various diagnostic approaches, while other studies have reported no associations in this regard. This discrepancy could be due to the various manifestations associated with CF.
- انتشار مقاله: 15-11-1396
- نویسندگان: Hamid Reza Kianifar,Yalda Rezaei,Ali Khakshour,Hassan Karami,Maryam Khalesi,Seyed Ali Jafari,Mohammad Ali Kiani,Veda Vakili,Seyed Ali Alamdaran
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Otorhinolaryngology
- نوع مقاله: Journal Article
- کلمات کلیدی: Pediatric,Ingestion,Key words: Foreign body
- چکیده:
- چکیده انگلیسی: Introduction: Determination of type and location of trapped objects and endoscopic observations among children with foreign-body ingestion.
Materials and Methods: We evaluated 105 endoscopic records of patients presenting with foreign-body ingestion from 2001–2011.
Results: Button batteries were the most common objects removed (41%). The lower segment of the esophagus was the most common trapping site. There was significant correlation between type of foreign body and its location of trapping. Abnormal endoscopic observations were reported in 33% patients. There was significant correlation between the type of foreign body and endoscopic observations. There was also a significant correlation between the location of the foreign body and endoscopic observation.
Conclusion: The pattern of foreign-body ingestion is somewhat different in our center compared with other studies. Awareness among parents about the prevention of this accident is an important step in decreasing the incidence of foreign-body ingestion.- انتشار مقاله: 23-09-1392
- نویسندگان: Seyed Ali Jafari,Maryam Khalesi,Simin Partovi,Mohammadali Kiani,Hamid Ahanchian,Hamidreza Kianifar
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Neonatology
- نوع مقاله: Journal Article
- کلمات کلیدی: Biliary atresia,cholestasis,TASC
- چکیده:
- چکیده انگلیسی: Introduction:
Early diagnosis of biliary atresia is very important for better outcome of treatment. Ultrasonography is one of the diagnostic tools for early differentiation of biliary atresia from other causes of neonatal cholestasis. It has been reported that triangular cord sign (TACS) in sonography is a reliable sign for diagnosis of biliary atresia. The aim of this study was to re-assess the accuracy of TACS alone and coupled with an abnormal gallbladder in the diagnosis of biliary atresia.
Methods:
Infants with prolonged cholestatic jaundice underwent ultrasonography and liver biopsy. Results of ultrasound scans (TASC and gallbladder abnormality) were compared with histopathological findings. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of Ultrasonographic findings for diagnosis of biliary atresia based on liver histopathology were studied.
Results:
The sensitivity, specificity and accuracy of TACS for diagnosis of biliary atresia were 36%, 95% and 77% respectively. Positive predictive value and negative predictive value was 77%. The sensitivity and specificity of gallbladder abnormality for diagnosis of biliary atresia were 36% and 88% respectively. Positive predictive value of TACS coupled with gallbladder abnormality for diagnosis of biliary atresia was 100%.
Conclusion:
The Ultrasonographic TACS is very specific for diagnosis of biliary atresia. Positive predictive value and accuracy of this sign is much higher than of gallbladder abnormality. The sensitivity of TACS for diagnosis of biliary atresia is very low.- انتشار مقاله: 02-12-1391
- نویسندگان: Seyed Ali Jafari,Mehrzad Mehdizadeh,Fatemeh Farahmand,Gholam Hossein Fallahi,Hamid Reza Kianifar
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Necrosis,Infant,Inflammatory bowel diseases
- چکیده:
- چکیده انگلیسی: Very-early-onset inflammatory bowel disease (VEO-IBD) has a distinct phenotype and should be considered a specific entity. VEO-IBD presents with very severe clinical pictures and is frequently known by an indeterminate colitis whose clinical remission is unmanageable. This study examines the case of a neonate with VEO-IBD, not responding to medical and surgical treatment. A 7-day-old Iranian female neonate presented with severe bloody diarrhea, poor feeding, abdominal distention, and dehydration suggesting severe proctocolitis due to an allergy to the protein in cow’s milk. The condition did not respond to the elimination of diet for 1 month. Infections, celiac disease, and cystic fibrosis were excluded. Immunological investigations were negative, but antineutrophil cytoplasmic antibodies were positive. Due to the neonate’s persistent symptoms and failure to thrive, upper and lower endoscopies were performed, showing ulcerative colitis. At the age of 4 months, she presented with signs and symptoms of toxic colitis and acute intestinal perforation, which prompted an emergency laparotomy. Due to the necrosis of the colon, hemicolectomy and colostomy were done. The patient was resuscitated and rehabilitated and was given glucocorticoid and mesalamine. We believe that the incidence of this problem is increasing, as is shown by the rise in the number of children under 10 years old being diagnosed. These patients require more aggressive therapeutic interventions than older IBD patients to achieve complete remission because they are more likely to have extensive colonic disease.
- انتشار مقاله: 10-08-1395
- نویسندگان: Sara Ebrahimi,Gholamreza Khademi,Seyed Ali Jafari,Nona Zaboli Nejad,Abdolreza Norouzy,Bahareh Imani
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Biotechnology
- نوع مقاله: Journal Article
- کلمات کلیدی: Pseudomonas aeruginosa,Statistical analysis,Rhamnolipid,Batch process,Fed batch process
- چکیده:
- چکیده انگلیسی: This paper presents a comparison between batch and three different sets of fed batch fermentations for
rhamnolipid production by Pseudomonas aeruginosa. The batch run was performed with 500 ml of culture
medium having the initial glycerol and sodium nitrate concentrations of 30 and 8.3 g/l, respectively. For a fed
batch run with nitrogen source in feed, 250 ml of the nitrogen excluded culture medium was in the bioreactor
initially, and 250 ml culture medium containing 16.6 g/l sodium nitrate was fed to the bioreactor continuously.
A similar procedure was repeated for fed batch runs with carbon, and phosphorus source in feed. Statistical
analysis showed that fed batch runs were better than batch in term of rhamnolipid production, and among
the fed batch runs the maximum amount of rhamnolipid. (4.12 g Rhamnose Equivalent/l) was for the fed
batch run with the carbon source in feed.- انتشار مقاله: 10-07-1391
- نویسندگان: Mohammad Ghomi Avili,Mohammad Hassan Fazaelipoor,Seyed Ali Jafari,Seyed Ahmad Ataei
- مشاهده