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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Toxoplasma gondii,IgG,IgM,Human Immunodeficiency Virus (HIV),Reactive Inhibition Antibodies
- چکیده:
- چکیده انگلیسی: Background & Objective: Toxoplasma gondii infection has public health importance and can lead to serious diseases in immunosuppressed patients, such as HIV cases. Appropriate control of T. gondii infection in HIV patients requires information about the prevalence of T. gondii antibodies and DNA in different population. In this study, we aimed to determine the prevalence of Toxoplasma gondii antibodies and DNA in HIV patients in Tehran, Iran.
Methods: A total of 149 HIV patients from the Iranian Research Center for HIV/AIDS, Tehran, Iran were enrolled in the study. Anti-Toxoplasma IgG and IgM were detected by ELISA and T. gondii DNA was evaluated by PCR and quantitative real-time PCR. IgG positive samples were also assessed for their avidity.
Results: Anti-Toxoplasma IgG and IgM were positive in 46.3% and 2.7% of cases respectively. 92.7% of our patients showed past infection and 4.3% revealed recently acquired toxoplasmosis based on their IgG avidity test. T. gondii DNA was not detected by PCR but real-time PCR results showed DNA in 4.7% of total patients and 13.1% of the IgG seropositive cases.
Conclusion: Our findings indicated that latent toxoplasmosis was relatively prevalent in our study population, but new T. gondii infection had low prevalence. Almost half of our patients were IgG negative and at risk of acquiring toxoplasma infection. Low copy numbers of DNA were detected in 4.7% of the cases without any clinical manifestation. Therefore, detection and monitoring of anti-Toxoplasma antibodies and DNA in HIV patients is substantial to estimate the risk of reactivation and new infection.- انتشار مقاله: 10-06-1397
- نویسندگان: Anahita Bavand,Arezoo Aghakhani,Minoo Mohraz,Mohammad Banifazl,Afsaneh Karami,Majid Golkar,Jalal Babaie,Parviz Saleh,Setareh Mamishi,Amitis Ramezani
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Prevalence,BK virus (BKV),Renal transplant candidates
- چکیده:
- چکیده انگلیسی: Background: Primary infection with BK virus (BKV) is occurred during childhood and usually asymptomatic, but after initial infection, BKV may persist lifelong in the kidney and genitourinary tract. Reactivation may occur in individuals with compromised immunity such as renal transplant recipients. Due to the role of BKV in BK virus-associated nephropathy (BKVAN) and potentially renal allograft rejection, the detection of BKV in renal transplant candidates is very important. The aim of this study was to evaluate the frequency of BK viremia in end stage renal disease cases who were candidates for renal transplantation. Methods: In this cross-sectional study, 50 cases with end stage renal disease who were candidates for renal transplantation were recruited from the main dialysis unit in Tehran, Iran. Presence of BK viremia was determined in plasma samples of cases using real time PCR. Results: A total of 50 renal transplant candidates with mean age 37.8±13 yr were enrolled in the study. Fifty two percent of subjects were male. Forty six (92%) of them were under HD and 4 (8%) were on PD. BK virus was not detected in any plasma samples of renal transplant candidates. Conclusion: This study showed absence of BK viremia in our renal transplant candidates. However, due to the important role of BKV in BKVAN and renal graft failure and rejection, further studies involving larger number of cases are required to elucidate the rate of the BKV in renal transplant candidates. How to cite this article: Jozpanahi M, Ramezani A, Ossareh S, Banifazl M, Bavand A, Mamishi S, et al. BK Viremia among Iranian Renal Transplant Candidates. Iran J Pathol. 2016; 11(3):210-5.
- انتشار مقاله: 26-07-1394
- نویسندگان: Manizheh Jozpanahi,Amitis Ramezani,Shahrzad Ossareh,Mohammad Banifazl,Anahita Bavand,Setareh Mamishi,Arezoo Aghakhani
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Coagulase negative staphylococcus (CoNS),Disc diffusion,E test
- چکیده:
- چکیده انگلیسی: Background and Objective: Reliable methods of detection of antimicrobial resistance are of paramount importance in the treatment and management of infections caused by coagulase negative staphylococci (CoNS). The objective of the present study was to compare and evaluate the performance of disc diffusion and E test (Epsilometer test) methods for antimicrobial testing of coagulase negative staphylococci in blood cultures. Materials and Methods: A total of 77 isolates of coagulase negative staphylococci from blood cultures were included as test strains. Antimicrobial susceptibility testing was performed by disc diffusion method for vancomycin. Minimum inhibitory concentration (MIC) determination was performed by E test for the same antimicrobial agent. All tests were performed on Mueller Hinton media. Results: Disc diffusion showed four resistant and 73 susceptible cases in examined strains with vancomycin. E test showed susceptibility of all strains to vancomycin. Decreased susceptibility to vancomycin were detected in 20 isolates in disc diffusion method but in 18 isolates by E test method Conclusion: Disc diffusion test may be used as a preliminary screening method for susceptibility testing of coagulase negative staphylococci. E test is a simple, easy and reliable method for determination of resistance in coagulase negative staphylococci, however, cost and limited availability in Iran limits its use.
- انتشار مقاله: 07-07-1393
- نویسندگان: Fatemeh Mahjoub,Mohammad Taghi Haghi Ashtiani,Seyed Kamal Aboutorabi,Setareh Mamishi,Farhad Asgari
- مشاهده
- جایگاه : پژوهشی
- مجله: Immunology and Genetics Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: Consensus,management,Symptoms,guideline,Primary immunodeficiency
- چکیده:
- چکیده انگلیسی: Primary immunodeficiency (PID) is a group of more than 400 distinct genetic disorders affecting both children and adults. As signs and symptoms of PID are usually heterogeneous and unspecific, based on the available human resources and laboratory facilities, diagnosis and follow-up of these patients can be challenging. In line with this notion, management and treatment of PID are practiced divergently in different PID centers. In order to reach a distinct national protocol and given the little evidence on appropriate or universal guidelines to improve the current status of management of the disease, the Iranian PID network designed a consensus suitable for regional resources. This review summarizes this PID guideline based on the importance of different clinical complications and the level of medical authority visiting those at the first line. Further, for each complication, appropriate interventions are mentioned to improve the approach.
- انتشار مقاله: 29-10-1397
- نویسندگان: Hassan Abolhassani,Marzieh Tavakol,Zahra Chavoshzadeh,Seyed Alireza Mahdaviani,Tooba Momen,Reza Yazdani,Gholamreza Azizi,Masoud Movahedi,Amir Ali Hamidieh,Nasrin Behniafard,Mohammamd Nabavi,Saba Arshi,Mohammad Hassan Bemanian,Morteza Fallahpour,Sima Shokri,Rasol Molatefi,Roya Sherkat,Afshin Shirkani,Reza Amin,Soheila Aleyasin,Reza Faridhosseini,Farahzad Jabbari-Azad,Iraj Mohammadzadeh,Javad Ghaffari,Alireza Shafiei,Arash Kalantari,Mahboubeh Mansouri,Mehrnaz Mesdaghi,Delara Babaie,Hamid Ahanchian,Maryam Khoshkhui,Habib Soheili,Mohammad Hossein Eslamian,Taher Cheraghi,Abbas Dabbaghzadeh,Mahmoud Tavassoli,Rasoul Nasiri Kalmarzi,Seyed Hamidreza Mortazavi,Sara Kashef,Hossein Esmaeilzadeh,Javad Tafaroji,Abbas Khalili,Fariborz Zandieh,Mahnaz Sadeghi-Shabestari,Sepideh Darougar,Fatemeh Behmanesh,Hedayat Akbari,Mohammadreza Zandkarimi,Farhad Abolnezhadian,Abbas Fayezi,Mojgan Moghtaderi,Akefeh Ahmadiafshar,Behzad Shakerian,Vahid Sajedi,Behrang Taghvaei,Mojgan Safari,Marzieh Heidarzadeh,Babak Ghalehbaghi,Seyed Mohammad Fathi,Behzad Darabi,Saeed Bazregari,Nasrin Bazargan,Alireza Khayatzadeh,Naser Javahertrash,Bahram Bashardoust,Mohammadali Zamani,Azam Mohsenzadeh,Sarehsadat Ebrahimi,Samin Sharafian,Ahmad Vosughimotlagh,Mitra Tafakoridelbari,Maziar Rahimi,Parisa Ashournia,Anahita Razaghian,Fatemeh Aghaeimeybodi,Setareh Mamishi,Nima Parvaneh,Nima Rezaei,Asghar Aghamohammadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Current Medical Mycology
- نوع مقاله: Journal Article
- کلمات کلیدی: Aspergillus nidulans,Chronic granulomatosis disease,Invasive aspergillosis,spinal cord
- چکیده:
- چکیده انگلیسی: Background and Purpose: Invasive aspergillosis (IA) of the central nervous system (CNS) is a devastating complication which is rarely reported in immunocompromised children.
In this case presentation, we reported a rare and fatal IA with spinal cord involvement in a 10-year-old child with X-linked chronic granulomatosis disease (CGD).
Case report: The child had a previous history of pulmonary tuberculosis. A cervical spine X-ray revealed the involvement of cervical vertebrae (T4/T5) and ribs causing spinal cord compression and epidural abscess. The patient underwent a decompressive laminectomy and mass removal. The histopathology and culture results suggested IA. Despite the aggressive and prolonged therapy, he died within one year. Aspergillus nidulans was identified as the causative agent based on morphological and molecular studies.
Conclusion: This synopsis represents the aggressive behavior of infection caused by A. nidulans in the CGD patient.- انتشار مقاله: 08-07-1398
- نویسندگان: Mahin Tavakoli,Mohammad T. Hedayati,Hossein Mirhendi,Sadegh Nooripoor-Sisakht,Newsha Hedayati,Fatemeh Saghafi,Setareh Mamishi
- مشاهده
- جایگاه : پژوهشی
- مجله: Current Medical Mycology
- نوع مقاله: Journal Article
- کلمات کلیدی: Aspergillus,Antifungal agents,Chronic Granulomatous Disease
- چکیده:
- چکیده انگلیسی: Background and Purpose: Chronic granulomatous disease (CGD) is an inherited disorder of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. This disorder results in recurrent life-threatening bacterial and fungal infections. Aspergillus species are the most common fungal infections in these patients.
Case Report: Herein, we present a case of fungal infection in a girl with CGD. We confirmed aspergillosis through the positive microscopic and macroscopic examinations, as well as radiology results. Invasive aspergillosis in this patient with pneumonia, lung abscess, and osteomyelitis of the ribs was not initially treated with amphotericin B (Am B) and recombinant interferon-gamma.
Conclusion: Among infectious diseases, fungal infections, in particular aspergillosis, remain a serious problem in CGD patients. Considering poor clinical response and deficient immune system, rapid diagnosis of fungal infection and optimizing the treatment of these patients are recommended.- انتشار مقاله: 18-04-1398
- نویسندگان: Setareh Mamishi,Kamiar Zomorodian,Farshid Saadat,Seyedeh Zohreh Jalali,Mohsen Geramishoar
- مشاهده