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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Epidemiology,Public health,Benign Breast Disease
- چکیده:
- چکیده انگلیسی: Background: Benign breast disease (BBD) is a factor strongly associated with breast cancer worldwide. Arg72Pro SNP association with breast cancer is controversial due to the suggestion that environmental factors are required to modulate such risk. There are no studies evaluating these environmental interactions of the aforementioned SNP within BBD. Aim: To determine the frequency of SNP Arg72Pro in a cohort of women diagnosed with BBD; and to investigate gene-environmental interactions with environmental factors. Results: The genotype frequency was 44.6% for Arg/Pro, 39.3% for Arg/Arg genotype, and 16.3% for Pro/Pro homozygote. Gene-environment interaction analysis shows that when Arg/Arg is considered as reference, there is an ORinteraction with Arg/Pro and fabric exposure (OR=1.90;95%CI:1.04,3.48), solvents (OR=2.21;95%CI:1.01,4.83) and chlorine, bleaches, disinfectants, and liquid wax exposure (OR=2.52;95%CI:1.07,5.91). Analysis with Pro/Pro genotype as the reference showed an interaction between alcohol consumption and recessive model (OR=1.58;95%CI:1.00,2.51). Gene-environmental interactions were observed too between exposure to hair dyes, straighteners or relaxers and Arg/Arg (OR=3.26;95%CI:1.21,8.82). Conclusion: The Arg/Pro genotype was the most frequent in the BBD cohort. When compared with the Arg/Arg genotype, the presence of Arg/Pro genotype and solvents, fabric and cleaning products exposure increased the risk of BBD. When compared with Pro/Pro genotype, there were interactions between recessive model with alcohol consumption and exposure to hair products on the risk of BBD.
- انتشار مقاله: 12-12-1398
- نویسندگان: Rafaela Soares Senra Da Costa,Rosalina Jorge Koifman,Viviane Ferreira Esteves,Marla Presa Raulino Schilling,Sergio Koifman,Ilce Ferreira Da Silva
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: risk factors,Epidemiology,Breast cancer,beliefs
- چکیده:
- چکیده انگلیسی: Objective: Evaluate the beliefs about the risk factors for breast cancer in a population of women from the western
Amazon and determine the factors associated with the higher belief scores presented by this population. Methods:
A population-based cross-sectional study included 478 women aged >40 years residing in Rio Branco, Acre, Brazil.
An American Cancer Society questionnaire was applied to assess the knowledge, attitudes, and beliefs about breast
cancer. Results: The main beliefs about the risk factors for breast cancer were breast trauma (95%), use of underwire
bra (58.5%), and a high number of sexual partners (55.5%). Women from younger age groups presented higher belief
scores (Bcoefficient: –0.04, 95% CI: –0.07; –0.01) than those of women from older age groups. A strong association was
noted between high knowledge scores of risk factors and signs/symptoms of the disease and high belief scores in the
study group (Bcoefficient:0.33;95%CI:0.28;0.38). Conclusion: The results indicate the existence of important beliefs
related to the risk factors for breast cancer. Women from younger age groups, women who have seen a gynecologist in
the past 2 years, and women who had more knowledge about the risk factors and signs and symptoms of breast cancer
had higher belief scores.- انتشار مقاله: 25-02-1397
- نویسندگان: Marla Presa Raulino Schilling,Ilce Ferreira Da Silva,Simone Perufo Opitz,Maria Fernanda De Sousa Oliveira Borges,Rosalina Jorge Koifman,Sergio Koifman
- مشاهده