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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,epithelial-mesenchymal transition,Gene,Lymphovascular invasion
- چکیده:
- چکیده انگلیسی: Background & Objective: Recent studies from gene profiling have revealed some genes that are overexpressed in the epithelial-mesenchymal transition (EMT) process and are responsible for its initiation and activation resulting in tumor progression and metastasis. The present study aimed to assess the role of genes involved in the EMT process and the association of these genes with axillary lymph node and vascular invasion in breast cancer (BC) patients.
Methods: In this case-control study, the tumor samples were initially extracted from 33 BC patients. The samples of 15 BC tissues without vascular and axillary invasion were also prepared from the biobank as a control group. RNAs from both tumor and control samples were extracted and stabilized. For assessing overexpression in tumor tissues of selected 18 genes, the real time technique was employed.
Results: There was a significant increase in MMP-2 gene fold expression in tumor cells with vascular invasion regardless of axillary involvement compared to the control group (P=0.0008) and also in the comparison of the control group with those with vascular invasion and not axillary lymph node involvement (P=0.003). In addition, gene fold expression of tissue inhibitors of metalloproteinase-1(TIMP-1) was decreased in axillary involving tumor cells compared to control group (P=0.045), and also in comparison with all samples that did not present any axillary lymph node involvements including the control group and the group with isolated vascular invasion (P=0.012).
Conclusion: Overexpression of MMP-2 and under-expression of TIMP-1 were associated with more invasive behavior in breast tumor cells.- انتشار مقاله: 01-06-1397
- نویسندگان: Alireza Abdollahi,Sepideh Jahanian,Nima Hemmati,Hadiseh Mohammadpour
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of School Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Dysmenorrhea,adolescence,Anthropometric indices,high school students
- چکیده:
- چکیده انگلیسی: Background: Primary dysmenorrhea is one of the most common gynecological complaints that can affect the quality of life. The exact pathophysiology of dysmenorrhea is not yet fully understood. However, some studies have suggested an association between anthropometric indices and dysmenorrhea. Objectives: We aimed to evaluated the association between anthropometric indices and dysmenorrhea. Methods: In this cross-sectional study conducted in Qazvin, Iran, during 2016, 400 high school students aged between 14 and 18 years old were enrolled based on the inclusion criteria. The relevant information and anthropometric indices were collected using a checklist. The data were analyzed by SPSS version 17. Results: Among 400 students, the prevalence of dysmenorrhea was 82.5%. There were significant differences in cycle length (29.15 ± 2.69 vs. 27.57 ± 2.38; P = 0.001), duration of menstruation (6.03 ± 1.11 vs. 5.65 ± 1.20; P = 0.011), hip circumference (93.13 ± 9.25 vs. 90.14 ± 12.15; P = 0.021), height (162.62 ± 5.47 vs. 160.72 ± 5.92; P = 0.01), and waist to hip ratio (WHR) (0.78 ± 0.06 vs. 0.81 ± 0.09; P = 0.001) between the groups with dysmenorrhea and without dysmenorrhea. Based on a logistic regression model, only WHR was a predictive protective factor for dysmenorrhea (OR = 0.896, CI95% = 0.821 - 0.971, P = 0.012) and height (OR = 1.057, CI95% = 1.006 - 1.111, P < 0.001), cycle length (OR = 1.238, CI95% = 1.117 - 1.372, P = 0.028), and menstruation length (OR = 1.269, CI95% = 1.002 - 1.608, P = 0.048) were risk factors. Conclusions: WHR and height were noted to be associated with dysmenorrhea. In addition, WHR was found to be a protective factor and height to be a risk factor.
- انتشار مقاله: 11-10-1348
- نویسندگان: Hamideh Pakniat,Sepideh Jahanian,Nima Hemmati,Fateme Ranjkesh
- مشاهده