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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Dentistry, Shiraz University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Statement of the Problem: The head and neck region is an uncommon site for metastatic involvement, but it can be the first and only symptom of primary cancer. The incidence of these tumors and their primary origins are limited in Iranian patients.Purpose: Therefore, this retrospective study aimed to investigate the frequency and the common related clinical manifestations, as well as, the most common types of cancers and the prevalent sites of the primary tumor.Materials and Method: All medical records related to patients with history of head and neck tumors between 1991 and 2011 at Iran Cancer Institute were evaluated and the essential information was statistically analyzed.Results: Sixty cases of cervical lymph node metastasis (0.36%) and 26 cases of head and neck metastatic tumors (0.16%) including 17 cases of distant cancer (0.10%) were recorded among all 16232 registered cancers. Out of all distant head and neck metastatic tumors, 4 cases were related to oral and maxillofacial area. Pain, swelling of neck, oral mucosa ulcer and dryness were the chief complaints. Squamous cell carcinoma and adenocarcinoma were the most frequent types of cancers. The most common metastatic sites were cervical musculature, scalp and parotid gland, and the most prevalent sites of primary tumor in females were breast and lung in males.Conclusion: According to these cases, the incidence rate of head and neck metastatic tumors seems to be low. However, feasible similarity of clinical presentation of oral metastatic lesions to benign lesions might result in misdiagnosis. Hence, biopsy is mandatory in any case with unusual clinical presentation, especially in patients with a known malignant disease.
- انتشار مقاله: 04-11-1393
- نویسندگان: Donia Sadri,Arash Azizi,Sareh Farhadi,Hojjat Shokrgozar,Navid Entezari
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Dermatology
- نوع مقاله: Journal Article
- کلمات کلیدی: Oral lichen planus,Multidrug Resistance,Candida glabrata
- چکیده:
- چکیده انگلیسی: Oral lichen planus (OLP) is a mucocutaneous disease characterized by inflammation leading to severe damage to the epithelial basal layer. This report describes a case of a 65-year-old Iranian female with a complaint of multifocal white lesions on the buccal and tongue mucosa with a reticular pattern and a focal pseudomembranous appearance (similar to thrush), together with burning symptoms for fourteen months. The patient was using topical fluocinolone acetonide 0.1%, two to three times a day at least for six months to control the ulcers and erythema. Molecular analysis of the thrush sample revealed Candida glabrata as the causative agent. Histopathologic examination confirmed the diagnosis of OLP. The minimum inhibitory concentration analysis was performed according to CLSI-M60 and revealed that this C. glabrata isolate was multidrug-resistant (resistant to nystatin, fluconazole, micafungin, and caspofungin). Finally, this patient was treated with amphotericin B oral suspension (0.5 g/5 ml) thrice daily for 14 days. The thrush disappeared completely and the patient no longer had any pain or burning sensations. Candida glabrata, the second most common cause of candidemia, is a major opportunistic fungal pathogen of humans that causes systemic as well as, mucosal and superficial infections. This case is the first case of OLP accompanied by multidrug-resistant C. glabrata.
- انتشار مقاله: 24-12-1398
- نویسندگان: Ensieh Lotfali,Alireza Firooz,Azam Fattahi,Mojgan Borzouie,Behzad Chalaki,Reza Ghasemi,Mohammad Mahdi Rabiei,Sareh Farhadi,Seyed Amirfarshad Esteghamat,Mobina Habibollahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: hookah,micronucleus,Repair index,buccal mucosa
- چکیده:
- چکیده انگلیسی: Background and aim: Cigarettes, hookah, and tobacco are the most important etiologic factors for oral cancers
and dysplastic lesions. This study was undertaken to determine the correlation between hookah use and the percentage
of cells with micronucleus, karyorrhexis, karyolysis, and broken egg in the buccal mucosa; and secondly to compare
hookah user and non-user in terms of repair index. Materials and methods: The present historical cohort study was
carried out on 72 samples taken from 36 hookah users and 36 control subjects. Smear samples were obtained from
participants’ buccal mucosa for cytological evaluation using Papanicolaou technique. Then, the percentages of cells
with micronucleus, karyorrhexis, karyolysis, and broken egg were recorded and the repair index was calculated. Data
were analyzed using Mann-Whitney U test. Results: A total of 72 samples taken from 36 hookah users and 36 control
subjects were evaluated. The means of micronucleus scores in the buccal mucosa cells of hookah users and controls
were 10.7±2.6 and 5.8±2.0, the karyorrhexis scores in the hookah users and controls were 0.1±0.06 and 0.04±0.06,
and the karyolysis scores in hookah users and controls were 0.16±0.05 and 0.08±0.06, respectively. These differences
were statistically significant between hookah users and controls (P<0.001). The broken egg score was 0.66±0.07 for the
hookah users and 0.03±0.04 for the control group, revealing a statistically significant difference (P<0.036). Finally, the
repair index values were 0.03±0.01 and 0.05±0.13 in hookah users and controls, respectively. This difference was also
significant (P<0.026). Conclusion: The percentages of cells with micronucleus, karyorrhexis, karyolysis, and broken
egg in the buccal mucosa of hookah users were significantly higher than those in control group; in addition, the repair
index of the buccal mucosa cells in hookah users was significantly lower than that in the control group.- انتشار مقاله: 31-05-1397
- نویسندگان: Mehrdad Taghibakhsh,Sareh Farhadi,Afsaneh Babaee,Maryam Sheikhi
- مشاهده