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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: cervical cancer,HPV,DNA,Sampling,Urine
- چکیده:
- چکیده انگلیسی: Background: WHO has recommended Visual Inspection with Acetic acid (VIA) or Human Papillomavirus (HPV)
DNA testing if feasible, for cervical cancer screening in low income countries. However, the number of women
undergoing screening is very low as a result of limited information, inadequate infrastructure and invasive nature of
sampling. Methods: A cross sectional study was carried out comparing HPV DNA detection by Polymerase Chain
Reaction (PCR) in paired cervical and urine samples procured from histologically confirmed cervical cancer cases.
Results: Amongst the samples collected from 114 cervical cancer cases, HPV DNA was tested positive in cervical
samples of 89 (78.1%) and urine samples of 55 (48.2%) patients. The agreement between the two sampling methods
was 66.7% and the kappa value was 0.35 indicating a fair agreement. The sensitivity of HPV detection using urine
samples was 59.6% (95% confidence interval 49.16%-69.15%) and the specificity was 92% (95% confidence interval
75.0%-97.8%). Conclusion: Even though not acceptable as an HPV DNA screening tool due to low sensitivity, the
urine sampling method is inexpensive and more socially acceptable for large epidemiological surveys in developing
countries to estimate the burden.- انتشار مقاله: 10-01-1398
- نویسندگان: Sasidharanpillai Sabeena,Santhosh Kuriakose,Damodaran Binesh,Jazeel Abdulmajeed,Giselle Dsouza,Amrutha Ramachandran,Bindu Vijaykumar,Sushama Aswathyraj,Santhosha Devadiga,Nagaraja Ravishankar,Govindakarnavar Arunkumar
- مشاهده