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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Dentistry, Shiraz University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Statement of the Problem: Neoadjuvant chemotherapy (NCH) is controversial in the treatment of oral squamous cell carcinoma (OSCC).Purpose: The aim of this study was to evaluate the efficacy of NCH on OSCC prognosis.Materials and Method: In this retrospective cohort study, 94 patients were studied in two groups. The patients in group 1 received NCH before the surgery, and those in group 2 underwent resection without any chemotherapy prior to surgery. The employed NCH agents consisted of cisplatin in combination with 5-fluorouracil in two treatment courses. Tumor size, lymph node involvement, age, and follow-up time were considered as variable factors of the study. Local recurrence (LR) and distant metastasis (DM) were outcomes of the study.Results: Comparison of LR and DM in various tumor sizes demonstrated no significant difference between the two groups (p> 0.05). Analysis of the data did not show any statistically significant difference between the groups for LR in subjects with N0, N1 and N2. Each one-year increase in age was associated with 10% increase in the hazard ratio (HR) (HR distance metastasis Y/N = 1.10, p= 0.05). In the same analysis, when considering LR as a dependent factor, LR risk in N2 was 3 times more than in N1 (p= 0.02). LR risk in N3 was 5 times more than in N1 [HR local recurrence (p= 0.006).Conclusion: Based on our results, neoadjuvant chemotherapy with combination of cisplatin and 5-fluorouracil may not improve prognosis of OSCC. However, further studies are suggested to assess other neoadjuvant chemotherapy protocols in OSCC patients.
- انتشار مقاله: 20-12-1393
- نویسندگان: Reza Tabrizi,Ata Garajei,Ehsan Shafiee,Samira Jamshidi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Single Nucleotide Polymorphism,Oral lichen planus,programmed cell death protein,Autoimmune Disease
- چکیده:
- چکیده انگلیسی: Background: The association between programmed cell death protein 1 (PD-1) variations and susceptibility to
autoimmune diseases has been recurrently reported. However, there is no report about its relationship with oral lichen
planus (OLP) as one of autoimmune diseases. Methods: We investigated the association between genetic predisposition
to OLP and two single nucleotide polymorphisms in PD-1. Results: GG, GA, and AA genotypes at position +7146
were found in 59 (80.8 %), 10 (13.7 %), and 4 (5.5 %) patients, and in 132 (77 %), 34 (20 %), and 5 (3 %) healthy
participants. CC, CT, and TT genotypes at position +7785 were found in 32 (43.8 %), 35 (47.9 %), and 6 (8.2 %) patients
and in 99 (58 %), 66 (39 %), and 6 (3 %) controls. Analysis indicated that patients’ genotypes were not statistically
different from controls’ genotypes at both positions +7146 (P = 0.35 and P = 0.98) and +7785 (P = 0.07 and P = 0.06).
Conclusion: The findings indicated that PD-1 SNPs at +7146 [PD-1.3] G/A and +7785 [PD-1.5] C/T was not associated
with susceptibility to OLP. However, further research with higher sample size and in different geographical regions is
needed in order to achieve the generalizability of the findings.- انتشار مقاله: 30-10-1396
- نویسندگان: Janan Ghapanchi,Hamid Ghaderi,Mohammad Reza Haghshenas,Samira Jamshidi,Fahimeh Rezazadeh,Azita Azad,Mitra Farzin,Reza Derafshi,Ahmad Hasan Kalantari
- مشاهده