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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Neoadjuvant chemotherapy,Pathologic complete response
- چکیده:
- چکیده انگلیسی: Background: Achievement of pathologic complete response (pCR) in breast cancer patients receiving neoadjuvant
chemotherapy (NAC) is associated with both overall survival and disease-free survival. The aim of present study was to identify clinical and pathological factors associated with achieving pCR in Iranian breast cancer patients receiving NAC. Methods: A retrospective review of all breast cancer patients treated with neoadjuvant chemotherapy between April 2012 and September 2016 at our institution was performed; 207 cases were evaluable for analysis. pCR was defined as having no residual invasive tumor in the breast surgical specimen removed following neoadjuvant therapy. Results: In univariate analysis, factors associated with pCR were age less than 35 years (p = 0.03), absence of Lymphovascular invasion (LVI) (p = 0.002) and negative hormone receptor status (p = 0.003). Hormone receptor status (P = 0.01; OR, 2.45; CI, 1.20 - 4.99) and LVI (P = 0.001; OR, 0.22; CI, 0.10 - 0.46) remained predictive variables in multivariate analysis after correction for the other variables. Conclusions: In conclusion, the results of this study suggests that presence of Lymphovascular invasion and positive hormone receptor status are associated with poorer response to neoadjuvant chemotherapy in breast cancer patients.- انتشار مقاله: 19-02-1396
- نویسندگان: Pegah Sasanpour,Saleh Sandoughdaran,Alireza Mosavi-Jarrahi,Mona Malekzadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Lymph node metastasis,axillary lymph node
- چکیده:
- چکیده انگلیسی: Background: Axillary lymph node metastasis is the most important predictive factor for recurrence risk and
survival in patients with invasive breast carcinoma. The aim of this study was to determine factors associated with
metastatic involvement of axillary lymph nodes in Iranian women with early breast cancer. Methods: This article reports
a retrospective study of 774 patients with T1-T2 breast cancer who underwent resection of the primary tumor and axillary
staging by SLNB and/or ALND between 2005 and 2015 at our institution. Results: Of the 774 patients included in this
study, 35.5% (275 cases) had axillary lymph node involvement at the time of diagnosis. Factors associated with nodal
involvement in univariate analyses were tumor size, lymphovascular invasion (LVI), tumor grade, ER/PR status and
HER2 expression. All factors identified with univariate analyses were entered into a multivariate logistic regression
model and tumor size (OR= 3.01, CI 2.01–4.49, P <0.001), ER/PR positivity (OR = 1.74, CI 1.1.16–2.62, P = 0.007)
and presence of LVI (OR = 3.3.8, CI 2.31–4.95, P <0.001) remained as independent predictors of axillary lymph node
involvement .Conclusions: In conclusion, the results of this study suggests that positive hormonal receptor status, LVI
and tumor size are predictive factors for ALNM in Iranian women with early breast cancer.- انتشار مقاله: 08-09-1396
- نویسندگان: Saleh Sandoughdaran,Mona Malekzadeh,Mohammad Esmaeil Akbari
- مشاهده